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Astrocyte derived TSP2 contributes to synaptic alteration and visual dysfunction in retinal ischemia/reperfusion injury
BackgroundDespite current intervention measures/therapies are able to ameliorate neuronal death following retinal injuries/diseases, the recovery of...
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Traumatic brain injury to primary visual cortex produces long-lasting circuit dysfunction
Primary sensory areas of the mammalian neocortex have a remarkable degree of plasticity, allowing neural circuits to adapt to dynamic environments....
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Cardiometabolic Disorder and Erectile Dysfunction
Erectile dysfunction (ED), which is defined as the inability to attain and maintain a satisfactory penile erection to sufficiently permit sexual...
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Circular RNA RSU1 promotes retinal vascular dysfunction by regulating miR-345-3p/TAZ
Diabetic mellitus-induced diabetic retinopathy is a significant cause of visual impairment and blindness in adults. Circular RNAs (circRNAs) have...
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Mir-204-5p alleviates mitochondrial dysfunction by targeting IGFBP5 in diabetic cataract
BackgroundCataract contributes to visual impairment worldwide, and diabetes mellitus accelerates the formation and progression of cataract. Here we...
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Mitochondrial dysfunction in long COVID: mechanisms, consequences, and potential therapeutic approaches
The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has introduced the medical community to the phenomenon of long COVID, a condition...
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16p11.2 deletion mice exhibit compromised fronto-temporal connectivity, GABAergic dysfunction, and enhanced attentional ability
Autism spectrum disorders are more common in males, and have a substantial genetic component. Chromosomal 16p11.2 deletions in particular carry...
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Ancestral photoreceptor diversity as the basis of visual behaviour
Animal colour vision is based on comparing signals from different photoreceptors. It is generally assumed that processing different spectral types of...
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A novel mouse model of mitochondrial disease exhibits juvenile-onset severe neurological impairment due to parvalbumin cell mitochondrial dysfunction
Mitochondrial diseases comprise a common group of neurometabolic disorders resulting from OXPHOS defects, that may manifest with neurological...
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Amelioration of olfactory dysfunction in a mouse model of Parkinson’s disease via enhancing GABAergic signaling
BackgroundOlfactory dysfunction is among the earliest non-motor symptoms of Parkinson’s disease (PD). As the foremost pathological hallmark,...
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Deubiquitinase JOSD2 improves calcium handling and attenuates cardiac hypertrophy and dysfunction by stabilizing SERCA2a in cardiomyocytes
Cardiac hypertrophy leads to myocardial dysfunction and represents a serious threat to global public health security. Deubiquitinating enzymes (DUBs)...
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Safety and efficacy of human ESC-derived corneal endothelial cells for corneal endothelial dysfunction
BackgroundResearch on human pluripotent stem cells (hPSCs) has shown tremendous progress in cell-based regenerative medicine. Corneal endothelial...
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Multifaceted mitochondria: moving mitochondrial science beyond function and dysfunction
Mitochondria have cell-type specific phenotypes, perform dozens of interconnected functions and undergo dynamic and often reversible physiological...
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Alzheimer’s disease-associated U1 snRNP splicing dysfunction causes neuronal hyperexcitability and cognitive impairment
Recent proteome and transcriptome profiling of Alzheimer’s disease (AD) brains reveals RNA splicing dysfunction and U1 small nuclear...
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Age-related visual impairments and retinal ganglion cells axonal degeneration in a mouse model harboring OPTN (E50K) mutation
Retinal ganglion cells (RGCs) axons are the signal carriers of visual information between retina and brain. Therefore, they play one of the important...
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Knockdown of Porf-2 restores visual function after optic nerve crush injury
Retinal ganglion cells (RGCs), the sole output neurons in the eyes, are vulnerable to diverse insults in many pathological conditions, which can lead...
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CTRP3 alleviates mitochondrial dysfunction and oxidative stress injury in pathological cardiac hypertrophy by activating UPRmt via the SIRT1/ATF5 axis
Pathological cardiac hypertrophy is an independent risk factor for heart failure. Disruption of mitochondrial protein homeostasis plays a key role in...
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Gut microbiota regulation of inflammatory cytokines and microRNAs in diabetes-associated cognitive dysfunction
AbstractType 2 diabetes mellitus (T2DM) has a major comorbidity known as diabetes-associated cognitive dysfunction (DACD). Studies have demonstrated...
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GABA decrease is associated with degraded neural specificity in the visual cortex of glaucoma patients
Glaucoma is an age-related neurodegenerative disease of the visual system, affecting both the eye and the brain. Yet its underlying metabolic...
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Calbindin 2-specific deletion of arginase 2 preserves visual function after optic nerve crush
We previously found that global deletion of the mitochondrial enzyme arginase 2 (A2) limits optic nerve crush (ONC)-induced neuronal death. Herein,...
