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Antiviral responses are shaped by heterogeneity in viral replication dynamics
Antiviral signalling, which can be activated in host cells upon virus infection, restricts virus replication and communicates infection status to...
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ACE2-dependent and -independent SARS-CoV-2 entries dictate viral replication and inflammatory response during infection
Excessive inflammation is the primary cause of mortality in patients with severe COVID-19, yet the underlying mechanisms remain poorly understood....
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A viral assembly inhibitor blocks SARS-CoV-2 replication in airway epithelial cells
The ongoing evolution of SARS-CoV-2 to evade vaccines and therapeutics underlines the need for innovative therapies with high genetic barriers to...
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TUT4/7-mediated uridylation of a coronavirus subgenomic RNAs delays viral replication
Coronaviruses are positive-strand RNA viruses with 3′ polyadenylated genomes and subgenomic transcripts. The lengths of the viral poly(A) tails...
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Zika virus triggers autophagy to exploit host lipid metabolism and drive viral replication
BackgroundZika virus (ZIKV), an arbovirus of global concern, has been associated with neurological complications including microcephaly in newborns...
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Therapeutic role of mTOR inhibitors in control of SARS-CoV-2 viral replication
By the end of 2019, COVID-19 was reported in Wuhan city of China, and through human-human transmission, this virus spread worldwide and became a...
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Inhibition of KIF20A suppresses the replication of influenza A virus by inhibiting viral entry
The influenza A virus (IAV) has caused several pandemics, and therefore there are many ongoing efforts to identify novel antiviral therapeutic...
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Bacterial vesicles block viral replication in macrophages via TLR4-TRIF-axis
Gram-negative bacteria naturally secrete nano-sized outer membrane vesicles (OMVs), which are important mediators of communication and pathogenesis....
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Mono-ADP-ribosylation by PARP10 inhibits Chikungunya virus nsP2 proteolytic activity and viral replication
Replication of viruses requires interaction with host cell factors and repression of innate immunity. Recent findings suggest that a subset of...
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Epigenetic addition of m5C to HBV transcripts promotes viral replication and evasion of innate antiviral responses
Eukaryotic five-methylcytosine (m 5 C) is an important regulator of viral RNA splicing, stability, and translation. However, its role in HBV...
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Subcellular Colocalization Assay of Host Factors with Viral Replication Complex in the dsRNA Reporter Nicotiana benthamiana
As obligate pathogens, plant viruses co-opt several host factors for viral replication. Double-stranded RNA (dsRNA) plays important roles in plants,...
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In vivo inhibition of the Ostreid Herpesvirus-1 (OsHV-1) replication in juveniles of the Pacific oyster Crassostrea gigas by a specific RNAi targeting the viral DNA polymerase gene
The global industrial farming of the Pacific oyster ( Crassostrea gigas ) has faced significant losses in production and a major negative social impact...
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SARS-CoV-2 ORF6 disrupts nucleocytoplasmic trafficking to advance viral replication
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ORF6 is an antagonist of interferon (IFN)-mediated antiviral signaling, achieved through...
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Activation of TCA cycle restrains virus-metabolic hijacking and viral replication in mouse hepatitis virus-infected cells
BackgroundOne of coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused coronavirus disease 2019 (COVID-19) pandemic...
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Dengue virus co-opts innate type 2 pathways to escape early control of viral replication
Mast cell products and high levels of type 2 cytokines are associated with severe dengue disease. Group 2 innate lymphoid cells (ILC2) are type-2...
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A model for network-based identification and pharmacological targeting of aberrant, replication-permissive transcriptional programs induced by viral infection
SARS-CoV-2 hijacks the host cell transcriptional machinery to induce a phenotypic state amenable to its replication. Here we show that analysis of...
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An overview of the role of Niemann-pick C1 (NPC1) in viral infections and inhibition of viral infections through NPC1 inhibitor
Viruses communicate with their hosts through interactions with proteins, lipids, and carbohydrate moieties on the plasma membrane (PM), often...
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TMPRSS2 isoform 1 downregulation by G-quadruplex stabilization induces SARS-CoV-2 replication arrest
BackgroundSARS-CoV-2 infection depends on the host cell factors angiotensin-converting enzyme 2, ACE2, and the transmembrane serinprotease 2,...
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The mitochondrial carrier homolog 2 is involved in down-regulation of influenza A virus replication
BackgroundThe mitochondrial carrier homolog 2 (MTCH2) is a mitochondrial outer membrane protein regulating mitochondrial metabolism and functions in...
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An intermediate state allows influenza polymerase to switch smoothly between transcription and replication cycles
Influenza polymerase (FluPol) transcribes viral mRNA at the beginning of the viral life cycle and initiates genome replication after viral protein...
