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Endothelial Protection of Vasoactive Intestinal Peptide Enhances Angiogenesis Mediated by eNOS Pathway Following Focal Cerebral Ischemia in Rats
In the present study, we investigated the effects of vasoactive intestinal peptide (VIP) on angiogenesis after cerebral ischemia and the mechanism...
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Vasoactive Intestinal Peptide Promotes Fracture Healing in Sympathectomized Mice
Vasoactive intestinal peptide (VIP) as a neuromodulator and neurotransmitter played a significant role in modulating bone homeostasis. Our previous...
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Effects of cancer-induced cachexia and administration of l-glutathione on the intestinal mucosa in rat
Walker-256 tumor is an experimental model known to promote cachexia syndrome, oxidative stress, and systemic inflammation. This study evaluated the...
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The crosstalk between enteric nervous system and immune system in intestinal development, homeostasis and diseases
The gut is the largest digestive and absorptive organ, which is essential for induction of mucosal and systemic immune responses, and maintenance of...
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Sars-Cov2 Induced Biochemical Mechanisms in Liver Damage and Intestinal Lesions
Multiple pathogenic mechanisms are found in SARS-CoV2 systemic inflammation. Oxidative stress, altered proteolysis, hypercoagulation, and metabolic...
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Evaluation Anti-inflammatory Effect of Conjugated Gold Nanoparticles with Cortistatin Peptide as Drug Delivery to Asthmatic Lung Tissue
Asthma is an inflammatory disease that affects the airways. Inflammation of the airway and reversible bronchoconstriction eventually lead to...
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Strategic Approaches to Improvise Peptide Drugs as Next Generation Therapeutics
In recent years, the occurrence of a wide variety of drug-resistant diseases has led to an increase in interest in alternate therapies. Peptide-based...
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Intestinal Peyer’s Patches: Structure, Function, and In Vitro Modeling
Backgound:Considering the important role of the Peyer’s patches (PPs) in gut immune balance, understanding of the detailed mechanisms that control...
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Peptide cargo administration: current state and applications
AbstractEffective delivery of drug molecules to the target site is a challenging task. In the last decade, several innovations in the drug delivery...
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Peptide Hormones in Medicine: A 100-Year History
AbstractThis review is devoted to the 100-year history of the investigation of peptide hormones and the creation of drugs on their basis, starting...
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Targeting intestinal flora and its metabolism to explore the laxative effects of rhubarb
Rhubarb, a traditional herb, has been used in clinical practice for hundreds of years to cure constipation, but its mechanism is still not clear...
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Pituitary Adenylate Cyclase-activating Polypeptide (PACAP) -derived Peptide MPAPO Stimulates Adipogenic Differentiation by Regulating the Early Stage of Adipogenesis and ERK Signaling Pathway
Regenerative medicine and tissue engineering have delivered new healing possibilities to the treatment of soft tissue defects, but the selection of...
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Neurochemical Features of Neuropeptide Y-ergic Enteric Submucosal Neurons in the Rat Small Intestine during Postnatal Ontogenesis
AbstractNeuropeptide Y (NPY) performs varied functions in the nervous system, including the regulation of vascular tone and...
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A Review on the Metabolism of 25 Peptide Drugs
Although peptide drugs make up only about 2% of all drugs approved by the United States Food and Drug Administration (FDA), they play important roles...
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LimosiLactobacillus pentosus Isolated from Mustard Relieves Drug-induced Constipation in Mice Fed a High-fat Diet by Modulating Enteric Neurotransmitter Function
Functional constipation is one of the most common gastrointestinal disorders. Oxidative stress can aggravate organ dysfunction. Enteric...
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Dynamic adult tracheal plasticity drives stem cell adaptation to changes in intestinal homeostasis in Drosophila
Coordination of stem cell function by local and niche-derived signals is essential to preserve adult tissue homeostasis and organismal health. The...
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Neurogenic Regulation of Cerebral Blood Flow
AbstractThe brain has a well-developed vascular network that allows it to consume up to 15% of cardiac output at its low weight relative to the...
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VIP alleviates sepsis-induced cognitive dysfunction as the TLR-4/NF-κB signaling pathway is inhibited in the hippocampus of rats
Cognitive dysfunction caused by sepsis-associated encephalopathy (SAE) is still poorly understood. It is reported that vasoactive intestinal peptide...
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Studies on host-foodborne bacteria in intestinal three-dimensional cell culture model indicate possible mechanisms of interaction
Spheroids of intestinal cells (Caco-2) were used to evaluate the adhesion/invasion ability of Listeria monocytogenes (pathogen) and Lactobacillus sakei ...
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An interaction graph approach to gain new insights into mechanisms that modulate cerebrovascular tone
Mechanisms to modulate cerebrovascular tone are numerous, interconnected, and spatially dependent, increasing the complexity of experimental study...
