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Long noncoding RNA SNHG1 silencing accelerates hepatocyte-like cell differentiation of bone marrow-derived mesenchymal stem cells to alleviate cirrhosis via the microRNA-15a/SMURF1/UVRAG axis
Bone marrow-derived mesenchymal stem cells (BMSCs) can differentiate into hepatocyte-like cells (HLCs) to attenuate cirrhosis. Long noncoding RNA...
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UV radiation resistance-associated gene (UVRAG) promotes cell proliferation, migration, invasion by regulating cyclin-dependent kinases (CDK) and integrin-β/Src signaling in breast cancer cells
Breast cancer is a highly heterogeneous group of human cancer with distinct genetic, biological and clinicopathological features. Triple-negative...
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Bioinformatics proved the existence of potential hub genes activating autophagy to participate in cartilage degeneration in osteonecrosis of the femoral head
The obvious degeneration of articular cartilage occurs in the late stage of osteonecrosis of the femoral head (ONFH), which aggravates the condition...
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Dual effect of ultraviolet B on cholesterol efflux and regulated by ultraviolet radiation resistance-associated gene-mediated autophagy
ObjectiveIn addition to diet and metabolism, the occurrence of foam cells and atherosclerosis are also related to environmental factors. Individual...
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ANKFY1 bridges ATG2A-mediated lipid transfer from endosomes to phagophores
Macroautophagy is a process that cells engulf cytosolic materials by autophagosomes and deliver them to lysosomes for degradation. The biogenesis of...
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TGFβ signaling links early life endocrine-disrupting chemicals exposure to suppression of nucleotide excision repair in rat myometrial stem cells
Environmental exposure to endocrine-disrupting chemicals (EDCs) is linked to the development of uterine fibroids (UFs) in women. UFs, non-cancerous...
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CUR5g, a novel autophagy inhibitor, exhibits potent synergistic anticancer effects with cisplatin against non-small-cell lung cancer
Autophagy, a highly conserved degradation process of eukaryotic cells, has been proven to be closely related to chemoresistance and metastasis of...
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DJ-1 binds to Rubicon to Impair LC-3 Associated Phagocytosis
The ability to effectively clear infection is fundamental to host survival. Sepsis, defined as dysregulated host response to infection, is a...
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CMTM7 as a novel molecule of ATG14L-Beclin1-VPS34 complex enhances autophagy by Rab5 to regulate tumorigenicity
BackgroundCMTM7 is a tumor suppressor that positively regulates EGFR degradation by promoting Rab5 activation, and plays a vital role in tumor...
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Genome-wide signatures of mammalian skin covering evolution
Animal body coverings provide protection and allow for adaptation to environmental pressures such as heat, ultraviolet radiation, water loss, and...
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Molecular imaging of the kinetics of hyperactivated ERK1/2-mediated autophagy during acquirement of chemoresistance
Alterations in key kinases and signaling pathways can fine-tune autophagic flux to promote the development of chemoresistance. Despite empirical...
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Loss of Concurrent Regulation of the Expression of BIF-1, BAX, and Beclin-1 in Primary and Metastatic Melanoma
AbstractMelanoma is one of the most aggressive and drug-resistant cancers. Despite novel promising therapeutic strategies, the prognosis of...
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Autophagy in Cancer: A Metabolic Perspective
Autophagy is an intracellular catabolic degradative process in which damaged cellular organelles, unwanted proteins and different cytoplasmic...
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Protective and deleterious effects of autophagy in the setting of myocardial ischemia/reperfusion injury: an overview
Introduction: Autophagy is known as a conserved mechanism in order to preserve cell survival under various stress conditions via maintaining cellular...
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Reduction of DHHC5-mediated beclin 1 S-palmitoylation underlies autophagy decline in aging
Autophagy is a lysosome-dependent degradation pathway essential for cellular homeostasis, which decreases with age. However, it is unclear how aging...
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Ontogeny of hepatic metabolism in two broiler lines divergently selected for the ultimate pH of the Pectoralis major muscle
BackgroundNutrient availability during early stages of development (embryogenesis and the first week post-hatch) can have long-term effects on...
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Autophagy as a Promising Therapeutic Target in Age-Associated Neurodegenerative Disorders
Aging, and the reason for the process, has been an area of research where strides can improve the healthspan and lifespan of people all over the...
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Viruses and autophagy: bend, but don’t break
Autophagy is a constitutive cellular process of degradation required to maintain homeostasis and turn over spent organelles and aggregated proteins....
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Role of protein degradation systems in colorectal cancer
Protein degradation is essential for maintaining protein homeostasis. The ubiquitin‒proteasome system (UPS) and autophagy–lysosome system are the two...
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Piceatannol enhances Beclin-1 activity to suppress tumor progression and its combination therapy strategy with everolimus in gastric cancer
The effects and regulation of Beclin-1—an autophagy-related protein—have not been fully defined, however, a negative correlation has been reported...