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Quantifying Substrate Protein Secretion via the Type III Secretion System of the Bacterial Flagellum
Protein transport across the cytoplasmic membrane is coupled to energy derived from ATP hydrolysis or the proton motive force. A sophisticated,...
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ExoU: A cytotoxin delivered by the type III secretion system of Pseudomonas aeruginosa
ExoU is a potent cytotoxin that is injected into host cells by the type III secretion system of Pseudomonas aeruginosa. It has recently been shown to...
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Construction of a constitutively active type III secretion system for heterologous protein secretion
AbstractProteins comprise a multibillion-dollar industry in enzymes and therapeutics, but bacterial protein production can be costly and inefficient....
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Cytosolic sorting platform complexes shuttle type III secretion system effectors to the injectisome in Yersinia enterocolitica
Bacteria use type III secretion injectisomes to inject effector proteins into eukaryotic target cells. Recruitment of effectors to the machinery and...
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Purification of the Transmembrane Polypeptide Channel Complex of the Salmonella Flagellar Type III Secretion System
Many motile bacteria employ the flagellar type III secretion system (fT3SS) to build the flagellum on the cell surface. The fT3SS consists of a...
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Type III secretion system effector YfiD inhibits the activation of host poly(ADP-ribose) polymerase-1 to promote bacterial infection
Modulation of cell death is a powerful strategy employed by pathogenic bacteria to evade host immune clearance and occupy profitable replication...
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Assay for Type III Secretion in Escherichia coli
The type III secretion system (T3SS) is crucial for the virulence of several pathogenic Escherichia coli species as well as for other gram-negative...
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Pseudomonas aeruginosa Antivirulence Strategies: Targeting the Type III Secretion System
The Pseudomonas aeruginosa type III secretion system (T3SS) is a complex molecular machine that delivers toxic proteins from the bacterial cytoplasm...
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Characterization of Virulence Genes Associated with Type III Secretion System and Biofilm Formation in Pseudomonas aeruginosa Clinical Isolates
Pseudomonas aeruginosa is a common pathogen with an increasing multidrug resistance (MDR) phenotype. Its virulence determinants include many factors...
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Prevalence of Type III Secretion System (T3SS) and Biofilm Development in Genetically Heterogeneous Clinical Isolates of Pseudomonas aeruginosa from Nigeria
Pseudomonas aeruginosa infection in seriously ill patients is a major concern due to its ability to form biofilm and secrete effector toxins. There...
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XrvB regulates the type III secretion system by directly repressing hrpG transcription in Xanthomonas oryzae pv. oryzicola
Xrv proteins are a group of regulators in Xanthomonas spp., belonging to the histone-like nucleoid-structuring (H-NS) proteins of Gram-negative...
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A step forward to the optimized HlyA type 1 secretion system through directed evolution
AbstractSecretion of proteins into the extracellular space has great advantages for the production of recombinant proteins. Type 1 secretion systems...
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Evolutionary Conservation, Variability, and Adaptation of Type III Secretion Systems
Type III secretion (T3S) systems are complex bacterial structures used by many pathogens to inject proteins directly into the cytosol of the host...
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Plant commensal type VII secretion system causes iron leakage from roots to promote colonization
Competition for iron is an important factor for microbial niche establishment in the rhizosphere. Pathogenic and beneficial symbiotic bacteria use...
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Analysis of SPI-1 Dependent Type III Secretion and Injection Using a NanoLuc Luciferase-Based Assay
Studies of bacterial protein secretion have relied on a variety of reporters that allow the tracking of secreted proteins. However, the lack of truly...
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Blue Native PAGE Analysis of Bacterial Secretion Complexes
Bacterial protein secretion systems serve to translocate substrate proteins across up to three biological membranes, a task accomplished by...
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The role of the type VI secretion system in the stress resistance of plant-associated bacteria
The type VI secretion system (T6SS) is a powerful bacterial molecular weapon that can inject effector proteins into prokaryotic or eukaryotic cells,...
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Bacterial type VI secretion system (T6SS): an evolved molecular weapon with diverse functionality
Bacterial secretion systems are nanomolecular complexes that release a diverse set of virulence factors/or proteins into its surrounding or...
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Profiling of Secreted Type 3 Secretion System Substrates by Salmonella enterica
Many of Salmonella enterica virulence-associated phenotypes, including its ability to manipulate various host pathways are mediated by translocation...
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Optimization of linear plasmid expression system for protein production and secretion in Bacillus thuringiensis
Bacillus thuringiensis , a safe bacterium widely used in agriculture for the biocontrol of pests, has great potential for protein production. The...
