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Methylation of hypoxia-inducible factor 3 subunit alpha contributes to poor prognosis in lung adenocarcinoma
Hypoxia-inducible factor 3 subunit alpha (HIF3A) has been implicated in various types of cancers, while its precise role in the lung adenocarcinoma...
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Bioinformatics approaches for classification and investigation of the evolution of the Na/K-ATPase alpha-subunit
BackgroundNa,K-ATPase is a key protein in maintaining membrane potential that has numerous additional cellular functions. Its catalytic subunit (α),...
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The Nascent Polypeptide-Associated Complex Subunit Alpha-Like Protein 1 (PmNACA1) Enhances Drought Tolerance by Scavenging ROS in Prunus mira Koehne
Extreme environmental stress significantly impacts plant growth. Drought stress is one of the most important abiotic stresses, adversely affecting...
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Staphylococcal alpha-toxin
Staphylococcal alpha-toxin, archetype of an oligomerizing pore-forming toxin, is produced and secreted as a water-soluble 34 kD monomer. High...
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Alpha Diversity
Population diversity is one important characteristic of a microbiome community, which is highly related to its environment. The change of diversity...
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Nitrate-responsive transcriptome analysis of rice RGA1 mutant reveals the role of G-protein alpha subunit in negative regulation of nitrogen-sensitivity and use efficiency
Key messageNitrate-responsive transcriptomic, phenotypic and physiological analyses of rice
RGA1 mutant revealed many novelRGA1 -regulated...
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Identification of G protein subunit alpha i2 as a promising therapeutic target of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a global health problem. Its incidence and mortality are increasing. Exploring novel therapeutic targets against...
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Molecular evolution steered structural adaptations in the DNA polymerase III α subunit of halophilic bacterium Salinibacter ruber
A significant portion of the earth has a salty environment, and the literature on bacterial survival mechanisms in salty environments is limited....
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Structural and mechanistic basis for nucleosomal H2AK119 deubiquitination by single-subunit deubiquitinase USP16
Epigenetic regulators have a crucial effect on gene expression based on their manipulation of histone modifications. Histone H2AK119...
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Protein phosphatase 1 regulatory subunit 15 A promotes translation initiation and induces G2M phase arrest during cuproptosis in cancers
Copper ions play a crucial role as cofactors for essential enzymes in cellular processes. However, when the intracellular concentration of copper...
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Molecular characterization of alpha subunit 1 of sodium pump (ATP1A1) gene in Camelus dromedarius: its differential tissue expression potentially interprets the role in osmoregulation
BackgroundDromedary or one-humped camel ( Camelus dromedarius ) is distinctively acclimatized to survive the arid conditions of the desert...
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Transcriptomic analysis of glucosidase II beta subunit (GluIIß) knockout A549 cells reveals its roles in regulation of cell adhesion molecules (CAMs) and anti-tumor immunity
Glucosidase II beta subunit (GluIIß), encoded from PRKCSH , is a subunit of the glucosidase II enzyme responsible for quality control of N-linked...
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Subunit Architecture and Atomic Structure of Voltage-Gated Ca2+ Channels
Voltage-gated calcium channels mediate calcium entry into cells in response to membrane depolarization. The high-voltage-activated Ca2+ channels that...
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A variant-proof SARS-CoV-2 vaccine targeting HR1 domain in S2 subunit of spike protein
The emerging SARS-CoV-2 variants, commonly with many mutations in S1 subunit of spike (S) protein are weakening the efficacy of the current vaccines...
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Prediction of dynamic allostery for the transmembrane domain of the sweet taste receptor subunit, TAS1R3
The sweet taste receptor plays an essential role as an energy sensor by detecting carbohydrates. However, the dynamic mechanisms of receptor...
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Nicotine-induced activation of cholinergic receptor nicotinic alpha 5 subunit mediates the malignant behaviours of laryngeal squamous epithelial cells by interacting with RABL6
Nicotine, a crucial constituent of tobacco smoke, can bind to and activate nicotinic acetylcholine receptors (nAChRs), thereby regulating various...
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Evaluating the Performance of PPE44, HSPX, ESAT-6 and CFP-10 Factors in Tuberculosis Subunit Vaccines
Mycobacterium tuberculosis ( M. tuberculosis ) is an intracellular pathogen causing long-term infection in humans that mainly attacks macrophages and...
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Proteomics Reveals Damaging Effect of Alpha-Cypermethrin Exposure in a Non-Target Freshwater Microalga Chlorella sp. NC-MKM
Alpha-cypermethrin, a pyrethroid pesticide, is frequently used on crops to prevent insect attacks. However, occasionally, due to drift, leaching, or...
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The nucleolar protein NOL12 is required for processing of large ribosomal subunit rRNA precursors in Arabidopsis
BackgroundNOL12 5′-3′ exoribonucleases, conserved among eukaryotes, play important roles in pre-rRNA processing, ribosome assembly and export. The...
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Abundance of the Membrane Proteome in Yeast Cells Lacking Spc1, a Non-catalytic Subunit of the Signal Peptidase Complex
The signal peptidase complex (SPC) mediates processing of signal peptides of secretory precursors. But, recent studies show that the eukaryotic SPC...
