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Mycorrhizal specificity differences in epiphytic habitat: three epiphytic orchids harbor distinct ecological and physiological specificity
Orchidaceae has diversified in tree canopies and accounts for 68% of vascular epiphytes. Differences in mycorrhizal communities among epiphytic...
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Evolution of a plant growth-regulatory protein interaction specificity
Specific protein–protein interactions (PPIs) enable biological regulation. However, the evolution of PPI specificity is little understood. Here we...
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ArdA Protein Specificity against Type I Restriction–Modification Systems
AbstractThe ArdA DNA-mimic antirestriction proteins inhibit type I restriction−modification (RMI) systems by binding instead of DNA to RMI. The ArdA...
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Circadian-driven tissue specificity is constrained under caloric restricted feeding conditions
Tissue specificity is a fundamental property of an organ that affects numerous biological processes, including aging and longevity, and is regulated...
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Selection of extended CRISPR RNAs with enhanced targeting and specificity
As CRISPR effectors like Cas9 increasingly enter clinical trials for therapeutic gene editing, a future for personalized medicine will require...
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Oligomeric Structure of Yeast and Other Invertases Governs Specificity
Invertases, or β-fructofuranosidases, are metabolic enzymes widely distributed among plants and microorganisms that hydrolyze sucrose and release...
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Molecular and structural basis of anti-DNA antibody specificity for pyrrolated proteins
Anti-DNA antibodies (Abs), serological hallmarks of systemic lupus erythematosus (SLE) and markers for diagnosis and disease activity, show a...
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An activity-specificity trade-off encoded in human transcription factors
Transcription factors (TFs) control specificity and activity of gene transcription, but whether a relationship between these two features exists is...
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Moonlighting enzymes: when cellular context defines specificity
It is not often realized that the absolute protein specificity is an exception rather than a rule. Two major kinds of protein multi-specificities are...
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DART.2: bidirectional synaptic pharmacology with thousandfold cellular specificity
Precision pharmacology aims to manipulate specific cellular interactions within complex tissues. In this pursuit, we introduce DART.2 (drug acutely...
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Horizontal transmission maintains host specificity and codiversification of symbionts in a brood parasitic host
In host-symbiont systems, interspecific transmissions create opportunities for host switches, potentially leading to cophylogenetic incongruence. In...
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specificity: an R package for analysis of feature specificity to environmental and higher dimensional variables, applied to microbiome species data
BackgroundUnderstanding the factors that influence microbes’ environmental distributions is important for determining drivers of microbial community...
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GABA decrease is associated with degraded neural specificity in the visual cortex of glaucoma patients
Glaucoma is an age-related neurodegenerative disease of the visual system, affecting both the eye and the brain. Yet its underlying metabolic...
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Dual specificity and target gene selection by the MADS-domain protein FRUITFULL
How transcription factors attain their target gene specificity and how this specificity may be modulated, acquiring different regulatory functions...
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Body-part specificity for learning of multiple prior distributions in human coincidence timing
During timing tasks, the brain learns the statistical distribution of target intervals and integrates this prior knowledge with sensory inputs to...
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Mechanisms of the Specificity of the CRISPR/Cas9 System in Genome Editing
AbstractThe CRISPR/Cas9 system, which was discovered recently, utilizes nucleases targeted by sequence complementarity and is originally intended to...
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Different responses of herbivore abundance to plant genotypic diversity depending on herbivore host specificity
Key messageThe response of herbivore abundance to birch genotypic diversity varies depending on the host specificity of the herbivores. Specialist,...
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Rational engineering of an elevator-type metal transporter ZIP8 reveals a conditional selectivity filter critically involved in determining substrate specificity
Engineering of transporters to alter substrate specificity as desired holds great potential for applications, including metabolic engineering....
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Intermediately synchronised brain states optimise trade-off between subject specificity and predictive capacity
Functional connectivity (FC) refers to the statistical dependencies between activity of distinct brain areas. To study temporal fluctuations in FC...
