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Nuclear smooth muscle α-actin participates in vascular smooth muscle cell differentiation
Missense variants throughout ACTA2 , encoding α-smooth muscle actin (αSMA), predispose to adult-onset thoracic aortic disease, but variants disrupting...
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Electrophysiology of Ctenophore Smooth Muscle
Unlike in the Cnidaria, where muscle cells are coupled together into an epithelium, ctenophore muscles are single, elongated, intramesogleal...
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Spaceflight effects on human vascular smooth muscle cell phenotype and function
The cardiovascular system is strongly impacted by the hazards of spaceflight. Astronauts spending steadily increasing lengths of time in microgravity...
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Genetic influence on vascular smooth muscle cell apoptosis
Vascular smooth muscle cell (VSMC) proliferation, migration, and apoptosis play important roles in many physiological processes and pathological...
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TMEM16A in smooth muscle cells acts as a pacemaker channel in the internal anal sphincter
Maintenance of fecal continence requires a continuous or basal tone of the internal anal sphincter (IAS). Paradoxically, the basal tone results...
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Paxillin participates in the sphingosylphosphorylcholine-induced abnormal contraction of vascular smooth muscle by regulating Rho-kinase activation
BackgroundThe Ca 2+ -independent contraction of vascular smooth muscle is a leading cause of cardiovascular and cerebrovascular spasms. In the...
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TGFβ2 mediates oxidative stress–induced epithelial-to-mesenchymal transition of bladder smooth muscle
Bladder outlet obstruction (BOO) is the primary clinical manifestation of benign prostatic hyperplasia, the most common urinary system disease in...
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Smooth muscle liver kinase B1 inhibits foam cell formation and atherosclerosis via direct phosphorylation and activation of SIRT6
Foam cell formation is a hallmark of the early phase of atherosclerosis. Growing evidence has demonstrated that vascular smooth muscle cells (VSMCs)...
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Reversible suspension culture of human vascular smooth muscle cells using the functional biopolymer FP003
Human vascular smooth muscle cells (SMCs) are adherent cells, and they cannot survive without scaffolds in suspension culture. Here, we aimed to...
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EGR1 transcriptionally regulates SVEP1 to promote proliferation and migration in human coronary artery smooth muscle cells
A low-frequency variant of sushi, von Willebrand factor type A, EGF, and pentraxin domain-containing protein 1 (SVEP1) is associated with the risk of...
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Nanopore long-read RNA sequencing reveals functional alternative splicing variants in human vascular smooth muscle cells
Vascular smooth muscle cells (VSMCs) are the major contributor to vascular repair and remodeling, which showed high level of phenotypic plasticity....
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NCOR1 maintains the homeostasis of vascular smooth muscle cells and protects against aortic aneurysm
Phenotypic modulation of vascular smooth muscle cells (VSMCs) plays critical roles in the pathogenesis of aortic aneurysm (AA). The function of...
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Deciphering smooth muscle cell heterogeneity in atherosclerotic plaques and constructing model: a multi-omics approach with focus on KLF15/IGFBP4 axis
BackgroundRuptured atherosclerotic plaques often precipitate severe ischemic events, such as stroke and myocardial infarction. Unraveling the...
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Network-based prioritization and validation of regulators of vascular smooth muscle cell proliferation in disease
Aberrant vascular smooth muscle cell (VSMC) homeostasis and proliferation characterize vascular diseases causing heart attack and stroke. Here we...
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N6-methyladenosine-driven miR-143/145-KLF4 circuit orchestrates the phenotypic switch of pulmonary artery smooth muscle cells
Pulmonary hypertension (PH) is characterized by vascular remodeling predominantly driven by a phenotypic switching in pulmonary artery smooth muscle...
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Nitric oxide and ion channels mediate l-cysteine-induced inhibition of colonic smooth muscle contraction
Previous studies have suggested that l -cysteine regulates gut motility through hydrogen sulfide. However, the mechanisms involved in the l -cysteine-in...
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Keratose Hydrogel Drives Differentiation of Cardiac Vascular Smooth Muscle Progenitor Cells: Implications in Ischemic Treatment
Peripheral artery disease (PAD) is a common vascular disorder in the extremity of limbs with limited clinical treatments. Stem cells hold great...
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Ahnak is required to balance calcium ion homeostasis and smooth muscle development in the urinary system
BackgroundVarious renal abnormalities, including hydronephrosis, polycystic kidney disease, and hydroureter, have been reported, and these...
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CircHAT1 regulates the proliferation and phenotype switch of vascular smooth muscle cells in lower extremity arteriosclerosis obliterans through targeting SFRS1
This study aimed to decipher the mechanism of circular ribonucleic acids (circRNAs) in lower extremity arteriosclerosis obliterans (LEASO). First,...
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Role of hsa_circ_0000280 in regulating vascular smooth muscle cell function and attenuating neointimal hyperplasia via ELAVL1
The pathological proliferation of cells in vascular smooth muscle underlies neointimal hyperplasia (NIH) development during atherosclerosis. Circular...
