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Modelling signalling pathways – a yeast approach
MAP kinase pathways are conserved signalling systems in eukaryotes that control stress responses, cell growth, and proliferation, as well as...
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Abscisic acid signalling
Signalling of abscisic acid (ABA) in plants is characterized by an amazing number of secondary messengers that are part of the pathway or modulate...
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Wnt signalling pathways as mediators of neuroprotective mechanisms: therapeutic implications in stroke
A stroke is a complicated neurological illness that occurs when there is a disruption in the blood flow to the brain. This disruption results in the...
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Unraveling the prevalence of various signalling pathways in non-small-cell lung cancer: a review
AbstractCancer has become a huge public health issue all around the world. The focus of research is on innovative cancer therapy techniques that...
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Oxidative stress signalling
Oxidative stress arises from an imbalance in the generation and removal of reactive oxygen species (ROS) within cells. ROS are produced during...
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Molecular genetics of genotoxic stress signalling in plants
Cells are under constant threat by endogenous and exogenous factors affecting DNA integrity. In response, complex signalling networks are activated...
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Reduced insulin/IGF-1 signalling upregulates two anti-viral immune pathways, decreases viral load and increases survival under viral infection in C. elegans
Reduced insulin/IGF-1 signalling (rIIS) improves survival across diverse taxa and there is a growing interest in its role in regulating immune...
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Emerging mechanistic understanding of cilia function in cellular signalling
Primary cilia are solitary, immotile sensory organelles present on most cells in the body that participate broadly in human health, physiology and...
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Characterisation of PDGF-BB:PDGFRβ signalling pathways in human brain pericytes: evidence of disruption in Alzheimer’s disease
Platelet-derived growth factor-BB (PDGF-BB):PDGF receptor-β (PDGFRβ) signalling in brain pericytes is critical to the development, maintenance and...
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Heavy metal signalling in plants: linking cellular and organismic responses
Heavy metals are required in plants as essential micronutrients or act as toxic compounds. How do plants perceive heavy metals and which signalling...
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Vascular dysfunction caused by loss of Brn-3b/POU4F2 transcription factor in aortic vascular smooth muscle cells is linked to deregulation of calcium signalling pathways
Phenotypic and functional changes in vascular smooth muscle cells (VSMCs) contribute significantly to cardiovascular diseases (CVD) but factors...
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Signalling cascades choreographing petal cell death: implications for postharvest quality
Senescence is a multifaceted and dynamic developmental phase pivotal in the plant's lifecycle, exerting significant influence and involving intricate...
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Stage-specific regulation of signalling pathways to differentiate pluripotent stem cells to cardiomyocytes with ventricular lineage
BackgroundPluripotent stem cells (PSCs) can be an ideal source of differentiation of cardiomyocytes in vitro and during transplantation to induce...
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Effect of Acidosis-Induced Signalling Pathways on Mitochondrial O2 Consumption of Tumour Cells
Signalling pathways such as ERK1/2, p38 or PI3K are activated in tumour cells by extracellular acidosis, which is a common phenomenon in human...
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Rapid Particle-Based Simulations of Cellular Signalling with the FLAME-Accelerated Signalling Tool (FaST) and GPUs
Cellular signalling is a vital process in living organisms for coordinating highly diverse responses to various stimuli. Particle-based modelling...
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Cl-amidine attenuates lipopolysaccharide-induced inflammation in human gingival fibroblasts via the JNK/MAPK, NF-κB, and Nrf2 signalling pathways
Cl-amidine has been reported to have anti-inflammatory properties in a variety of diseases. However, the role of Cl-amidine in periodontal disease...
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Signalling
Signalling is a non-biological paradigm for information processing. Biologists borrowed concepts from foreign disciplines, e.g. mechanical...
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A master of all trades – linking retinoids to different signalling pathways through the multi-purpose receptor STRA6
Retinoids are a group of vitamin A-related chemicals that are essential to chordate mammals. They regulate a number of basic processes, including...
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Redox regulation of UPR signalling and mitochondrial ER contact sites
Mitochondria and the endoplasmic reticulum (ER) have a synergistic relationship and are key regulatory hubs in maintaining cell homeostasis....
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Cellular heterogeneity in TNF/TNFR1 signalling: live cell imaging of cell fate decisions in single cells
Cellular responses to TNF are inherently heterogeneous within an isogenic cell population and across different cell types. TNF promotes cell survival...
