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Monitoring Agonist-Induced Activity of PI3-Kinase in HEK-293 with a Genetically Encoded Sensor
AbstractIn non-excitable cells, IP3-driven Ca 2+ release plays a pivotal role in agonist-induced Ca 2+ signaling. The efficiency of the...
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The LRR receptor-like kinase ALR1 is a plant aluminum ion sensor
Plant survival requires an ability to adapt to differing concentrations of nutrient and toxic soil ions, yet ion sensors and associated signaling...
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QseC sensor kinase modulates the human microbiota during enterohemorrhagic Escherichia coli O157:H7 infection in the Simulator of the Human Intestinal Microbial Ecosystem (SHIME®)
Enterohemorrhagic Escherichia coli (EHEC) is an important gastrointestinal pathogen known for its ability to cause hemorrhagic colitis and induce...
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Localization of the Remnant of a Cell Wall Sorting Signal and Its Interaction with a Sensor Kinase
Sortases are highly conserved enzymes with endopeptidase and transpeptidase activities in Gram-positive bacteria. Sortase A cleaves within an...
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A metabolite sensor subunit of the Atg1/ULK complex regulates selective autophagy
Cells convert complex metabolic information into stress-adapted autophagy responses. Canonically, multilayered protein kinase networks converge on...
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Does MPK4/12-HT1 function as a CO2/bicarbonate sensor to regulate the stomatal conductance under high CO2 levels?
Key messageRecently, a HT1 protein has been identified which causes continuous opening of stomata because of its kinase activity. However, reversible...
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The putative sensor histidine kinase VadJ coordinates development and sterigmatocystin production in Aspergillus nidulans
The VosA-VelB heterocomplex governs expression of several genes associated with fungal development and secondary metabolism. In this study, we have...
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Pyruvate kinase, a metabolic sensor powering glycolysis, drives the metabolic control of DNA replication
BackgroundIn all living organisms, DNA replication is exquisitely regulated in a wide range of growth conditions to achieve timely and accurate...
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Monitoring the Kinase Activity of Heme-Based Oxygen Sensors and Its Dependence on O2 and Other Ligands Using Phos-Tag Electrophoresis
The nonradioactive method, sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) in the presence of Phos-tag (Phos-tag...
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TORSEL, a 4EBP1-based mTORC1 live-cell sensor, reveals nutrient-sensing targeting by histone deacetylase inhibitors
BackgroundMammalian or mechanistic target of rapamycin complex 1 (mTORC1) is an effective therapeutic target for diseases such as cancer, diabetes,...
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Human microbiota modulation via QseC sensor kinase mediated in the Escherichia coli O104:H4 outbreak strain infection in microbiome model
BackgroundThe intestinal microbiota plays a crucial role in human health, adjusting its composition and the microbial metabolites protects the gut...
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The Role of SnRK1 Kinase in the Response of the Photosynthetic Machinery to Salinity Stress
AbstractIn plants, SnRK1 (Sucrose non-fermenting-Related protein Kinase 1) is one of the major activators of catabolic processes, including...
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Regulation of Plant Infection Processes by MAP Kinase Pathways in Ascomycetous Pathogens
Plant pathogenic fungi use the well-conserved MAP kinase (MAPK) pathways to mediate responses to external stimuli and regulate various infection and...
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Assaying Protein Kinase A Activity Using a FRET-Based Sensor Purified from Mammalian Cells
Protein Kinase A (PKA) is the major intracellular receptor for cAMP. Research into this prototype kinase is supported by kinase assays that are...
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The role of the ER stress sensor IRE1 in cardiovascular diseases
Despite enormous advances in the treatment of cardiovascular diseases, including I/R injury and heart failure, heart diseases remain a leading cause...
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The Glycine Max Abscisic Acid-Activated Protein Kinase-Like Kinase 1 (GmAALK1) Modulates Drought Stress Response
Abscisic acid-activated protein kinases (AAPK) are key components in abscisic acid (ABA) signalling and have been implicated in mediating responses...
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The role of histidine kinase signalling in response to salt stress
Salt stress is a global environmental problem, which affects various biochemical and physiological processes in plants and significantly decreases...
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Functions of the RIP kinase family members in the skin
The receptor interacting protein kinases (RIPK) are a family of serine/threonine kinases that are involved in the integration of various stress...
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Discovery of a natural small-molecule AMP-activated kinase activator that alleviates nonalcoholic steatohepatitis
Non-alcoholic steatohepatitis (NASH) is a primary cause of cirrhosis and hepatocellular carcinoma. Unfortunately, there is no approved drug treatment...
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A glutamine sensor that directly activates TORC1
TOR complex 1 (TORC1) is an evolutionarily-conserved protein kinase that controls cell growth and metabolism in response to nutrients, particularly...
