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Universally Accessible Structural Data on Macromolecular Conformation, Assembly, and Dynamics by Small Angle X-Ray Scattering for DNA Repair Insights
Structures provide a critical breakthrough step for biological analyses, and small angle X-ray scattering (SAXS) is a powerful structural technique...
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3D Structural Analysis of Long Noncoding RNA by Small Angle X-ray Scattering and Computational Modeling
Small angle X-ray scattering (SAXS) has been widely applied as an enabling integrative technique for comprehensive analysis of the structure of...
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The Ambiguity Issue in Solving Inverse Problems of Small-Angle Scattering: A Consistent Approach Using an Insulin Receptor-Related Receptor as an Example. Methods for Interpreting SAXS Data
AbstractThe construction of three-dimensional models of protein macromolecules is a serious challenge due to the possible ambiguity of solving the...
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Minimizing Heterogeneity of Protein Samples for Metal Transporter Proteins Using SAXS and Metal Radioisotopes
The scattering profiles at small angles, obtained after an X-ray beam is incident on biological samples (protein), are nowadays successfully used to...
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Small-Angle X-Ray Scattering for Macromolecular Complexes
Small angle X-ray scattering (SAXS) is a versatile technique that can provide unique insights in the solution structure of macromolecules and their...
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Using Small-angle X-ray Scattering to Characterize Biological Systems: A General Overview and Practical Tips
Small-angle X-ray Scattering (SAXS) is a versatile and powerful technique with applications in a wide range of fields. The continuous improvements in...
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The Multiscale Ernwin/SPQR RNA Structure Prediction Pipeline
Aside from the well-known role in protein synthesis, RNA can perform catalytic, regulatory, and other essential biological functions which are...
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Interpreting SAXS /WAXS Data with Explicit-Solvent Simulations: A Practical Guide
Small- and wide-angle X-ray scattering (SAXS/WAXS/SWAXS) have evolved to be accurate tools used to gain structural information of biomolecules in...
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In situ SAXS analysis of the water effects on the thickness evolution of nanocellulose within bamboo fiber
To investigate the thickness evolution of nanocellulose in water, in situ SAXS (small angle X-ray scattering) was used to characterize bamboo fibers....
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Atomistic ensemble of active SHP2 phosphatase
SHP2 phosphatase plays an important role in regulating several intracellular signaling pathways. Pathogenic mutations of SHP2 cause developmental...
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Form factor determination of biological molecules with X-ray free electron laser small-angle scattering (XFEL-SAS)
Free-electron lasers (FEL) are revolutionizing X-ray-based structural biology methods. While protein crystallography is already routinely performed...
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Determining Rg of IDPs from SAXS Data
There is a great interest within the research community to understand the structure–function relationship for intrinsically disordered proteins...
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Nucleoid-Associated Proteins HU and IHF: Oligomerization in Solution and Hydrodynamic Properties
AbstractStructure and function of bacterial nucleoid is controlled by the nucleoid-associated proteins (NAP). In any phase of growth, various NAPs,...
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Combined analysis of microstructures within an annual ring of Douglas fir (Pseudotsuga menziesii) by dynamic mechanical analysis and small angle X-ray scattering
Dynamic mechanical analysis (DMA) and small angle X-ray scattering (SAXS) measurements of water-saturated wood of Douglas fir ( Pseudotsuga menziesii )...
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Effect of the Coat Protein N-Terminal Domain Structure on the Structure and Physicochemical Properties of Virions of Potato Virus X and Alternanthera Mosaic Virus
AbstractThe amino acid sequences of the coat proteins (CPs) of the potexviruses potato virus X (PVX) and alternanthera mosaic virus (AltMV) share...
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Neurotransmitter uptake of synaptic vesicles studied by X-ray diffraction
The size, polydispersity, and electron density profile of synaptic vesicles (SVs) can be studied by small-angle X-ray scattering (SAXS), i.e. by...
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Combining Biophysical Methods for Structure–Function Analyses of RNA in Solution
RNA-level regulation by riboswitches relies on the specific binding of small metabolites to the aptamer domain to trigger substantial conformational...
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Röntgenstrukturanalyse
Röntgenkristallographie ist die meistverwendete Methode in der molekularen Strukturbiologie. Bis Mitte 2019 wurden über 150.000 dreidimensionale...
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Molecular mechanism of specific HLA-A mRNA recognition by the RNA-binding-protein hMEX3B to promote tumor immune escape
Immunotherapy, including immune checkpoint inhibitors and adoptive cell transfer, has obtained great progress, but their efficiencies vary among...
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Synthetic β-sheets mimicking fibrillar and oligomeric structures for evaluation of spectral X-ray scattering technique for biomarker quantification
BackgroundArchetypical cross-β spines sharpen the boundary between functional and pathological proteins including β-amyloid, tau, α-synuclein and...
