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1. Isolated Cardiac Ryanodine Receptor Function Varies Between Mammals

   Concerted robust opening of cardiac ryanodine receptors’ (RyR2) Ca ²⁺ release 1oplasmic reticulum (SR) is fundamental for normal systolic cardiac...

   Catherine Carvajal, Jiajie Yan, ... Michael Fill in The Journal of Membrane Biology

   Article 29 January 2024
   

2. Probing spatiotemporal PKA activity at the ryanodine receptor and SERCA2a nanodomains in cardomyocytes

   Spatiotemporal regulation of subcellular protein kinase A (PKA) activity for precise substrate phosphorylation is essential for cellular responses to...

   Bing Xu, Ying Wang, ... Yang K. **ang in Cell Communication and Signaling

   Article Open access 14 September 2022
   

3. Subcellular localization of hippocampal ryanodine receptor 2 and its role in neuronal excitability and memory

   Ryanodine receptor 2 (RyR2) is abundantly expressed in the heart and brain. Mutations in RyR2 are associated with both cardiac arrhythmias and...

   Florian Hiess, ****g Yao, ... S. R. Wayne Chen in Communications Biology

   Article Open access 01 March 2022
   

4. Alterations in calmodulin-cardiac ryanodine receptor molecular recognition in congenital arrhythmias

   Calmodulin (CaM), a ubiquitous and highly conserved Ca ²⁺ -sensor protein involved in the regulation of over 300 molecular targets, has been recently...

   Giuditta Dal Cortivo, Carlo Giorgio Barracchia, ... Daniele Dell’Orco in Cellular and Molecular Life Sciences

   Article Open access 08 February 2022
   

5. “Ryanopathies” and RyR2 dysfunctions: can we further decipher them using in vitro human disease models?

   The regulation of intracellular calcium (Ca ²⁺ ) homeostasis is fundamental to maintain normal functions in many cell types. The ryanodine receptor...

   Yvonne Sleiman, Alain Lacampagne, Albano C. Meli in Cell Death & Disease

   Article Open access 01 November 2021
   

6. Live-cell photoactivated localization microscopy correlates nanoscale ryanodine receptor configuration to calcium sparks in cardiomyocytes

   Ca ²⁺ sparks constitute the fundamental units of Ca ²⁺ release in cardiomyocytes. Here we investigate how ryanodine receptors (RyRs) collectively...

   Yufeng Hou, Martin Laasmaa, ... William E. Louch in Nature Cardiovascular Research

   Article Open access 15 March 2023
   

7. MALAT1 knockdown protects from bronchial/tracheal smooth muscle cell injury via regulation of microRNA-133a/ryanodine receptor 2 axis

   Asthma has significant impacts on living quality particularly in children. Long noncoding RNA (lncRNA) MALAT1 plays a crucial role in neonatal...

   Mingzhu Yang, Li Wang in Journal of Biosciences

   Article 18 March 2021
   

8. CRISPR/Cas9 Gene Editing of RYR2 in Human iPSC-Derived Cardiomyocytes to Probe Ca2+ Signaling Aberrancies of CPVT Arrhythmogenesis

   Human-induced pluripotent stem cells (hiPSCs) provide a powerful platform to study biophysical and molecular mechanisms underlying the...

   Naohiro Yamaguchi, **ao-Hua Zhang, Martin Morad in Cardiac Gene Therapy

   Protocol 2022
   

9. Enhancing calmodulin binding to cardiac ryanodine receptor completely inhibits pressure-overload induced hypertrophic signaling

   Cardiac hypertrophy is a well-known major risk factor for poor prognosis in patients with cardiovascular diseases. Dysregulation of intracellular Ca ²⁺ ...

   Michiaki Kohno, Shigeki Kobayashi, ... Masafumi Yano in Communications Biology

   Article Open access 26 November 2020
   

10. Loss of Ryanodine Receptor 2 impairs neuronal activity-dependent remodeling of dendritic spines and triggers compensatory neuronal hyperexcitability

    Dendritic spines are postsynaptic domains that shape structural and functional properties of neurons. Upon neuronal activity, Ca ²⁺ transients trigger...

    Fabio Bertan, Lena Wischhof, ... Pierluigi Nicotera in Cell Death & Differentiation

    Article Open access 08 July 2020
    

11. The function and regulation of calsequestrin-2: implications in calcium-mediated arrhythmias

    Cardiac arrhythmias are life-threatening events in which the heart develops an irregular rhythm. Mishandling of Ca ²⁺ within the myocytes of the heart...

    Elliot T. Sibbles, Helen M. M. Waddell, ... Michelle L. Munro in Biophysical Reviews

    Article 07 January 2022
    

12. p38γ/δ activation alters cardiac electrical activity and predisposes to ventricular arrhythmia

    Ventricular fibrillation (VF) is a leading immediate cause of sudden cardiac death. There is a strong association between aging and VF, although the...

    Rafael Romero-Becerra, Francisco M. Cruz, ... Guadalupe Sabio in Nature Cardiovascular Research

    Article 27 November 2023
    

13. Personalized medicine in the dish to prevent calcium leak associated with short-coupled polymorphic ventricular tachycardia in patient-derived cardiomyocytes

    Background

    Polymorphic ventricular tachycardia (PMVT) is a rare genetic disease associated with structurally normal hearts which in 8% of cases can...

    Yvonne Sleiman, Steven Reiken, ... Albano C. Meli in Stem Cell Research & Therapy

    Article Open access 23 September 2023
    

14. Vascular dysfunction caused by loss of Brn-3b/POU4F2 transcription factor in aortic vascular smooth muscle cells is linked to deregulation of calcium signalling pathways

    Phenotypic and functional changes in vascular smooth muscle cells (VSMCs) contribute significantly to cardiovascular diseases (CVD) but factors...

    Vaishaali Yogendran, Laura Mele, ... Vishwanie S. Budhram-Mahadeo in Cell Death & Disease

    Article Open access 25 November 2023
    

15. The Role of Ryanodine and IP₃-receptors in Calcium Responses to Tricyclic Antidepressants in Rat Neocortical Neurons

    Abstract

    Tricyclic antidepressants, specifically amitriptyline (ATL) and desipramine (DES) are currently used to treat depression and chronic pain of...

    S. I. Boikov, D. A. Sibarov, ... S. M. Antonov in Journal of Evolutionary Biochemistry and Physiology

    Article 01 May 2021
    

16. Knockout of M-LP/Mpv17L, a newly identified atypical PDE, induces physiological afferent cardiac hypertrophy in mice

    M-LP/Mpv17L (Mpv17-like protein) is an atypical cyclic nucleotide phosphodiesterase (PDE) without the molecular structure characteristic of the PDE...

    Reiko Iida, Misuzu Ueki, Toshihiro Yasuda in Transgenic Research

    Article Open access 18 October 2023
    

17. Metabolism and Receptor Mechanisms of Niacin Action

    Abstract

    The paper discusses the metabolism of niacin, also known as vitamin B3 or PP, and the mechanisms of its receptor-induced functions in the...

    S. E. Boronovskiy, V. S. Kopylova, Y. R. Nartsissov in Cell and Tissue Biology

    Article 15 April 2024
    

18. TRPC7 regulates the electrophysiological functions of embryonic stem cell-derived cardiomyocytes

    Background

    Biological pacemakers consisting of pluripotent stem cell-derived cardiomyocytes are potentially useful for treating bradycardia. However,...

    **anji Liu, Rui Zhao, ... Suk Ying Tsang in Stem Cell Research & Therapy

    Article Open access 03 May 2021
    

19. Regulatory mechanisms of ryanodine receptor/Ca²⁺ release channel revealed by recent advancements in structural studies

    Ryanodine receptors (RyRs) are huge homotetrameric Ca ²⁺ release channels localized to the sarcoplasmic reticulum. RyRs are responsible for the...

    Haruo Ogawa, Nagomi Kurebayashi, ... Takashi Murayama in Journal of Muscle Research and Cell Motility

    Article Open access 10 February 2020
    

20. Crystal structure of diamondback moth ryanodine receptor Repeat34 domain reveals insect-specific phosphorylation sites

    Background

    Ryanodine receptor (RyR), a calcium-release channel located in the sarcoplasmic reticulum membrane of muscles, is the target of...

    Tong Xu, Zhiguang Yuchi in BMC Biology

    Article Open access 09 October 2019