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The associations between TMAO-related metabolites and blood lipids and the potential impact of rosuvastatin therapy
BackgroundTrimethylamine N-oxide (TMAO)-related metabolites are associated with the pathogenesis of atherosclerotic cardiovascular disease (ASCVD)...
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Hyperlipidemia patients carrying LDLR splicing mutation c.1187-2A>G respond favorably to rosuvastatin and PCSK9 inhibitor evolocumab
Mutations in the LDL receptor gene LDLR cause familial hypercholesterolemia (FH); however, the pharmacogenomics of specific LDLR mutations remains...
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Relationship between genetic polymorphism of drug transporters and the efficacy of Rosuvastatin, atorvastatin and simvastatin in patients with hyperlipidemia
BackgroundTo determine the effect of genetic polymorphism of drug transporters on the efficacy of treatment with Rosuvastatin , Atorvastatin and Simvastatin...
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Rosuvastatin inhibit spheroid formation and epithelial–mesenchymal transition (EMT) in prostate cancer PC-3 cell line
There is a growing body of evidence suggesting antitumor activity of statins. In metastasis and invasion of cancer the Epithelial–Mesenchymal...
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Rosuvastatin protects against coronary microembolization-induced cardiac injury via inhibiting NLRP3 inflammasome activation
Coronary microembolization (CME), a common reason for periprocedural myocardial infarction (PMI), bears very important prognostic implications....
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Comparative efficacy between atorvastatin and rosuvastatin in the prevention of cardiovascular disease recurrence
BackgroundThere is no randomized clinical trials with recurrence of atherosclerotic cardiovascular disease (ASCVD) as a major outcome with...
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Upregulation of rate-limiting enzymes in cholesterol metabolism by PKCδ mediates endothelial apoptosis in diabetic wound healing
Diabetic foot ulcer (DFU) is a prevalent complication of diabetes that poses significant challenges in terms of treatment and management. It is...
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Antihyperlipidemic Activity of Ethanolic and Aqueous Extracts of Asparagus Racemosus and Chlorophytum Borivilianum Leaves in Albino Rats
Hyperlipidemia is basically a risk factor for causing heart related diseases, strokes, high blood pressure, diabetes, renal disorders, etc. Herbal...
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Main differences between two highly effective lipid-lowering therapies in subclasses of lipoproteins in patients with acute myocardial infarction
BackgroundLarge observational studies have shown that small, dense LDL subfractions are related to atherosclerotic cardiovascular disease. This study...
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Referral rate, profile and degree of control of patients with familial hypercholesterolemia: data from a single lipid unit from a Mediterranean area
BackgroundThe challenging rigorous management of hypercholesterolemia promotes referral to specialized units. This study explored the need, based on...
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Augmenting Mesenchymal Stem Cell-Based Therapy of the Infarcted Myocardium with Statins
Preconditioning (PC) affords the most potent cytoprotective effects ever known in the physiological system. Since the publication of the first report...
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Augmenting Mesenchymal Stem Cell-Based Therapy of the Infarcted Myocardium with Statins
Preconditioning (PC) affords the most potent cytoprotective effects ever known in the physiological system. Since the publication of the first report...
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Statins and Hemostasis: Therapeutic Potential Based on Clinical Evidence
HemostasisHemostasis preserves blood fluidity and prevents its loss after vessel injury. The maintenance of blood fluidity requires a delicate...
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Non-invasive skin cholesterol testing: a potential proxy for LDL-C and apoB serum measurements
BackgroundLipid management is the first line of treatment for decreasing the incidence of cardiovascular events in patients with coronary heart...
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Effect of alirocumab on coronary plaque in patients with coronary artery disease assessed by optical coherence tomography
BackgroundProprotein convertase subtilisin kexin type 9 (PCSK9) inhibitors have been demonstrated to produce significantly greater reduction in LDL...
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The influence of the intestinal microflora to the efficacy of Rosuvastatin
BackgroundIntestinal microflora has been shown to play essential roles in the clinical therapies of metabolic diseases. The present study is aiming...
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The association of statin therapy and cancer: a meta-analysis
BackgroundStatins are routinely prescribed to lower cholesterol and have been demonstrated to have significant benefits in atherosclerotic...
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International practice patterns of dyslipidemia management in patients with chronic kidney disease under nephrology care: is it time to review guideline recommendations?
BackgroundIn contrast to guidelines related to lipid therapy in other areas, 2012 Kidney Disease Improving Global Outcomes (KDIGO) guidelines...
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Multi-filter Based Signed Graph Convolutional Networks for Predicting Interactions on Drug Networks
The prediction of drug-drug interactions (DDIs) and drug-target interactions (DTIs) is currently a prominent area of interest within the domain of...
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Effect of statins on post-contrast acute kidney injury: a multicenter retrospective observational study
BackgroundPost-contrast acute kidney injury (PC-AKI) is a severe complication of coronary angiography (CAG) and percutaneous coronary intervention...
