SpringerLink
Log in

Antihyperlipidemic Activity of Ethanolic and Aqueous Extracts of Asparagus Racemosus and Chlorophytum Borivilianum Leaves in Albino Rats

  • Research Article
  • Published:
Proceedings of the National Academy of Sciences, India Section B: Biological Sciences Aims and scope Submit manuscript

Abstract

Hyperlipidemia is basically a risk factor for causing heart related diseases, strokes, high blood pressure, diabetes, renal disorders, etc. Herbal remedies are widely used by all sections of society, whether as traditional remedies or modern medicine. In this research work, the hyperlipidemic activity of aqueous and ethanolic extracts of Asparagus racemosus leaves and Chlorophytum borivilianum leaves was determined and the effect of these extracts on weight gain in hyperlipidemia-induced rats was determined. The aqueous and ethanolic extracts of A. racemosus (Leaves) and C. borivilianum (Leaves) were evaluated for serum lipid profile in hyperlipidemic-induced rats. It was concluded that the serum lipid profile in aqueous and ethanolic of C. borivilianum (Leaves) was found to be decreased than aqueous and ethanolic extract of A. racemosus (Leaves) when compared with standard (Rosuvastatin). The aqueous extract of C. borivilianum (Leaves) significantly lowered the body weight by the reduction in the serum lipid profile. Thus, in this study it was proved that aqueous extract of C. borivilianum (Leaves) decreased the level of hyperlipidemia in comparison to other extracts.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Bahadur B, Reddy KJ, Rao MLN (2007) Medicinal plants: an overview. In: Advances in medicinal plants. Universities Press, Hyderabad. https://doi.org/10.13040/IJPSR.0975-8232.6(10).4103-12

  2. Agrawal A, Sharma R (2019) A study of antiobesity, hypolipidemic and anti-atherogenic activity of poly herbal formulation against high fat diet-induced obesity in albino rats. J Adv Res Pharm Sci Pharmacol Interv 2(2):1–5. https://doi.org/10.4103/0975-9476.118707

    Article  Google Scholar 

  3. Harborne JB (1984) Methods of plant analysis. In: Phytochemical methods. Springer, Dordrecht, pp 1–36. https://doi.org/10.1007/978-94-009-5570-7_1

  4. Kibwage IO, Mwangi JW, Thoithi GN (2005) Quality control of herbal medicines. East Central African J Pharm Sci 8(2):27–30. https://doi.org/10.4314/ecajps.v8i2.9720

    Article  Google Scholar 

  5. Mangold HK (1969) Aliphatic lipids. In: Thin-layer chromatography. Springer, Berlin, pp 363–421. https://doi.org/10.1002/lipi.19710731210

  6. Chamoli M, Varshney VK, Srivastava PK, Pandey R, Dayal R (2013) HPTLC Method development and analysis of bioactive Marker Shatavarin IV in Asparagus racemosus intercropped with Morus alba. Anal Chem Lett 3(2):125–138. https://doi.org/10.1080/22297928.2013.838456

    Article  CAS  Google Scholar 

  7. Adhikari K, Anuradha KN, Suchitra NP (2018) Pharmacognostic evaluation and HPTLC finger printing of rhizome of Chlorophytum borivilianum Sant. and F. from Nepal. Pharmacogn J 10(5):963–968. https://doi.org/10.5530/pj.2018.5.163

    Article  CAS  Google Scholar 

  8. Pragya M, Nesar A, Tarique M, Arshiya S, Bagga P, Prashant S (2016) Effect of Terminalia bellerica against high fat diet induced hyperlipidemia and obesity. World J Pharmaceut Sci 4:33–37. https://doi.org/10.5667/tang.2019.0013

    Article  Google Scholar 

  9. Rao AS, Ahmed MF, Ibrahim M (2012) Hepatoprotective activity of Melia azedarach leaf extract against simvastatin induced Hepatotoxicity in rats. J Appl Pharm Sci 2(7):144. https://doi.org/10.7324/JAPS.2012.2721

    Article  Google Scholar 

  10. Venkatesh G (2010) Anti Urolithiatic and anti hyperlipidemic activity of Coleus aromaticus An explanation of the underlying mechanisms. Int J Phytomedicine 2(3):284–291. https://doi.org/10.1080/26895293.2021.1968959

    Article  CAS  Google Scholar 

  11. Sivagamasundari R (2017) Anti-hyperlipidemic activity of aerial parts of delonix elata on high cholesterol diet induced hyperlipidemia in rats. Doctoral dissertation, Mohamed Sathak AJ College of Pharmacy, Chennai. http://repository-tnmgrmu.ac.in/id/eprint/6416

  12. Zulet MA, Barber A, Garcin H, Higueret P, Martinez JA (1999) Alterations in carbohydrate and lipid metabolism induced by a diet rich in coconut oil and cholesterol in a rat model. J Am Coll Nutr 18(1):36–42. https://doi.org/10.1080/07315724.1999.10718825

    Article  CAS  PubMed  Google Scholar 

  13. Chaiyodsilp S, Chaiyodsilp P, Pureekul T, Srisawas R, Khunaphakdipong Y (2013) A prospective randomized trial for reduction of serum low density lipoprotein (LDL) with plant Stanol Ester mixed in coffee in a Hypercholesterolemic Thai population. Bangk Med J 5:9–9. https://doi.org/10.1155/2015/353164

    Article  Google Scholar 

  14. Mensink RP, Ebbing S, Lindhout M, Plat J, van Heugten MM (2002) Effects of plant stanol esters supplied in low-fat yoghurt on serum lipids and lipoproteins, non-cholesterol sterols and fat soluble antioxidant concentrations. Atherosclerosis 160(1):205–213. https://doi.org/10.1016/s0021-9150(01)00562-7

    Article  CAS  PubMed  Google Scholar 

  15. Plat J, Brufau G, Dallinga-Thie GM, Dasselaar M, Mensink RP (2009) A plant stanol yogurt drink alone or combined with a low-dose statin lowers serum triacylglycerol and non-HDL cholesterol in metabolic syndrome patients. J Nutr 139(6):1143–1149. https://doi.org/10.3945/jn.108.103481

    Article  CAS  PubMed  Google Scholar 

  16. Awal MA, Rashid MU, Ahmed KW, Asadi ZS, Islam K (1999) Effect of karela and fenugreek on lipid profile in hypocholesterolemic diabetic patients. Bangladesh J Physiol Pharmacol 15:6–8. https://doi.org/10.3329/bjp.v1i2.490

    Article  Google Scholar 

  17. Mang B, Wolters M, Schmitt B (2006) Effects of a cinnamon extract on plasma glucose, HbA1c, and serum lipids in diabetes mellitus type 2. Eur J Clin Invest 36(5):340–344. https://doi.org/10.1111/j.1365-2362.2006.01629.x

    Article  CAS  PubMed  Google Scholar 

  18. Kitchen BJ, Masters CJ, Winzor DJ (1973) Effects of lipid removal on the molecular size and kinetic properties of bovine plasma arylesterase. Biochem J 135(1):93–99. https://doi.org/10.1042/bj1350093

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Harshal P, Pritam C, Kamat S (2018) An overview of traditionally used herb, Colocasia esculenta, as a phytomedicine. Medicinal Aromat Plants. https://doi.org/10.4172/2167-0412.1000317

    Article  Google Scholar 

  20. Narasimhacharya AVRL, Visavadiya NP (2005) Hypolipidemic and antioxidant activities of Asparagus racemosus in hypercholesteremic rats. Indian J Pharmacol 37:376–380. https://doi.org/10.4103/0253-7613.19074

    Article  Google Scholar 

  21. Abu Saleh MM, Rashid MU, Asadi AZS et al (2006) Hypolipidemic effects of fenugreek seed powder. Bangladesh J Pharmacol 1:64–67. https://doi.org/10.3329/bjp.v1i2.490

    Article  Google Scholar 

  22. Miettinen TA, Puska P et al (2003) Efficacy and safety of plant Stanols and sterols in the management of blood cholesterol levels. Mayo Clin Proc 78:965–978. https://doi.org/10.15420/ecr.2010.6.3.18

  23. Zahmatkesh M, Khodashenas-Roudsari M (2013) Comparing the therapeutic effects of three herbal medicine (cinnamon, fenugreek, and coriander) on hemoglobin A1C and blood lipids in type II diabetic patients. Chron Dis J 1(2):74–82. https://doi.org/10.22122/cdj.v1i2.56

    Article  Google Scholar 

  24. Samani KG, Farrokhi E (2014) Effects of cumin extract on oxLDL, paraoxanase 1 activity, FBS, total cholesterol, triglycerides, HDL-C, LDL-C, Apo A1, and Apo B in in the patients with hypercholesterolemia. Int J Health Sci (Qassim) 8(1):39–43. https://doi.org/10.12816/0006070

    Article  PubMed  Google Scholar 

  25. Gupta R, Verma S (2015) Study of effects of consumption of powdered fenugreek seeds on serum lipid profile in patients with type 2 diabetes mellitus. Int J Biomed Adv Res 6(01):57–59. https://doi.org/10.7439/ijbar.v6i1.1493

    Article  Google Scholar 

  26. Johnson R, McNutt P, MacMahon S, Robson R (1997) Use of the Friedewald formula to estimate LDL-cholesterol in patients with chronic renal failure on dialysis. Clin Chem 43(11):2183–2210. https://doi.org/10.1093/clinchem/43.11.2183

    Article  CAS  PubMed  Google Scholar 

  27. Muruganandan S (2011) Chemerin, a novel peroxisome proliferator-activated receptor γ (PPARγ) target gene that promotes mesenchymal stem cell adipogenesis. J Biol Chem 286:23982–23995. https://doi.org/10.1074/jbc.m111.220491

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Islam D, Huque A, Mohanta LC, Lipy EP, Rahman MN, Sultana A, Prodhan UK (2017) Studies on the hypoglycemic and hypolipidemic effects of Nelumbo nucifera leaf in long-evans rats. J Diabetes Mellitus 7(3):55–70. https://doi.org/10.4236/jdm.2017.73005

    Article  CAS  Google Scholar 

  29. Suanarunsawat T, Ayutthaya WDN, Songsak T, Thirawarapan S, Poungshompoo S (2011) Lipid-lowering and antioxidative activities of aqueous extracts of Ocimum sanctum L. leaves in rats fed with a high-cholesterol diet. Oxidative Med Cell Longev. https://doi.org/10.1155/2011/962025

    Article  Google Scholar 

Download references

Acknowledgements

The authors are very thankful to the honorable Vice-Chancellor of Banasthali Vidyapith for providing the research facility.

Author information

Authors and Affiliations

  1. Department of Pharmacy, Banasthali Vidyapith, Banasthali, Rajasthan, 304022, India

    Ruchi Singh & Sumitra Nain

Authors
  1. Ruchi Singh
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sumitra Nain
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sumitra Nain.

Ethics declarations

Conflict of Interest

All authors declare no conflict of interest.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Significance statement: These studies and investigation will provide a way for other plants to be used as an important for treating various diseases. This research will help in the development of eco-friendly, cost-effective, and economic techniques for controlling hyperlipidemia and related diseases.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Singh, R., Nain, S. Antihyperlipidemic Activity of Ethanolic and Aqueous Extracts of Asparagus Racemosus and Chlorophytum Borivilianum Leaves in Albino Rats. Proc. Natl. Acad. Sci., India, Sect. B Biol. Sci. 93, 431–441 (2023). https://doi.org/10.1007/s40011-022-01440-5

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40011-022-01440-5

Keywords

Search

Navigation