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Reversible protein phosphorylation in higher plants: focus on state transitions
Reversible protein phosphorylation is one of the comprehensive mechanisms of cell metabolism regulation in eukaryotic organisms. The review describes...
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Regulation of SNARE assembly by protein phosphorylation
Protein phosphorylation is emerging as an important regulatory mechanism that controls the secretory pathway. It enables coupling between the...
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Phosphorylation of the compartmentalized PKA substrate TAF15 regulates RNA–protein interactions
Spatiotemporal-controlled second messengers alter molecular interactions of central signaling nodes for ensuring physiological signal transmission....
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Multi-omics analysis identifies drivers of protein phosphorylation
BackgroundPhosphorylation of proteins is a key step in the regulation of many cellular processes including activation of enzymes and signaling...
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Identifying Protein Phosphorylation Site-Disease Associations Based on Multi-Similarity Fusion and Negative Sample Selection by Convolutional Neural Network
As one of the most important post-translational modifications (PTMs), protein phosphorylation plays a key role in a variety of biological processes....
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Text Mining and Machine Learning Protocol for Extracting Human-Related Protein Phosphorylation Information from PubMed
In the modern health care research, protein phosphorylation has gained an enormous attention from the researchers across the globe and requires...
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Characterization of PIF4 Phosphorylation by SPA1
The PHYTOCHROME INTERACTING FACTORs (PIFs) play pivotal roles in regulating thermo- and photo-morphogenesis in Arabidopsis. One of the main hubs in...
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Protein Phosphorylation in Plant Cell Signaling
Owing to their sessile nature, plants have evolved sophisticated sensory mechanisms to respond quickly and precisely to the changing environment. The...
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Liquid–liquid phase separation of TZP promotes PPK-mediated phosphorylation of the phytochrome A photoreceptor
Phytochrome A (phyA) is the plant far-red (FR) light photoreceptor and plays an essential role in regulating photomorphogenic development in FR-rich...
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The cAMP-dependent phosphorylation footprint in response to heat stress
Key messagecAMP modulates the phosphorylation status of highly conserved phosphosites in RNA-binding proteins crucial for mRNA metabolism and...
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Reversible suspension culture of human vascular smooth muscle cells using the functional biopolymer FP003
Human vascular smooth muscle cells (SMCs) are adherent cells, and they cannot survive without scaffolds in suspension culture. Here, we aimed to...
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Discovery and Characterization of Linear Motif Mediated Protein-Protein Complexes
There are myriads of protein-protein complexes that form within the cell. In addition to classical binding events between globular domains, many...
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FERONIA coordinates plant growth and salt tolerance via the phosphorylation of phyB
Phosphorylation modification is required for the modulation of phytochrome B (phyB) thermal reversion, but the kinase(s) that phosphorylate(s) phyB...
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Protein Phosphorylation Response to Abiotic Stress in Plants
Plants are an important part of nature because as photoautotrophs, they provide a nutrient source for many other living organisms. Due to their...
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Phosphorylation of PP2Ac by PKC is a key regulatory step in the PP2A-switch-dependent AKT dephosphorylation that leads to apoptosis
BackgroundAlthough GqPCR activation often leads to cell survival by activating the PI3K/AKT pathway, it was previously shown that in several cell...
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Pyruvate kinase M2 sustains cardiac mitochondrial quality surveillance in septic cardiomyopathy by regulating prohibitin 2 abundance via S91 phosphorylation
The endogenous mitochondrial quality control (MQC) system serves to protect mitochondria against cellular stressors. Although mitochondrial...
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Phosphorylation Site Motifs in Plant Protein Kinases and Their Substrates
Protein phosphorylation is an important cellular regulatory mechanism affecting the activity, localization, conformation, and interaction of...
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Targeted Mass Spectrometry Analysis of Protein Phosphorylation by Selected Ion Monitoring Coupled to Parallel Reaction Monitoring (tSIM/PRM)
Recent developments in targeted mass spectrometry-based proteomics have provided new methodological solutions for accurate and quantitative analysis...
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Synaptic retrograde regulation of the PKA-induced SNAP-25 and Synapsin-1 phosphorylation
BackgroundBidirectional communication between presynaptic and postsynaptic components contribute to the homeostasis of the synapse. In the...
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Use of Mitotic Protein Kinase Inhibitors and Phospho-Specific Antibodies to Monitor Protein Phosphorylation During the Cell Cycle
Reversible protein phosphorylation regulates the transitions between different phases of the cell cycle ensuring proper segregation of the duplicated...