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Exploring the Versatility of 4-Aminopyridine and Its Analogues in Managing Demyelinating Diseases (A Review)
Abstract4-Aminopyridine, a small molecule has attracted considerable interest within the neuroscience and pharmacology communities owing to its...
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Cell-based Therapies for Corneal and Retinal Disorders
Maintenance of the visual function is the desired outcome of ophthalmologic therapies. The shortcomings of the current treatment options, like...
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The molecular mechanism of human stem cell-derived extracellular vesicles in retinal repair and regeneration
Extracellular vesicles (EVs), including microvesicles (MVs) and exosomes, play a critical role in metabolic regulation and intracellular...
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Kinase activity profiling identifies putative downstream targets of cGMP/PKG signaling in inherited retinal neurodegeneration
Inherited retinal diseases (IRDs) are a group of neurodegenerative disorders that lead to photoreceptor cell death and eventually blindness. IRDs are...
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Effect of genotype on individual response to the pharmacological treatment of glaucoma: a systematic review and meta-analysis
The social impact of glaucoma is worth of note: primary open-angle glaucoma (POAG) is one of the leading causes of irreversible blindness worldwide,...
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Neuro-ophthalmological changes in healthy females exposed to a 5-day dry immersion: a pilot study
After exposure to microgravity, astronauts undergo microgravity-induced thoraco-cephalic fluid shift, which may lead to ocular changes called...
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Molecular Mechanisms and Structural Basis of Retigabine Analogues in Regulating KCNQ2 Channel
AbstractKCNQ2 channel is one of the important members of potassium voltage-gated channel. KCNQ2 is closely related to neuronal excitatory diseases...
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Retinal Tissue Bioengineering, Materials and Methods for the Treatment of Glaucoma
Background:Glaucoma, a characteristic type of optic nerve degeneration in the posterior pole of the eye, is a common cause of irreversible vision...
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Role of curcumin in ameliorating hypertension and associated conditions: a mechanistic insight
Curcumin, belongs to the curcuminoid family, is a natural phenolic compound, presenting low bioavailability and pleiotropic activity. Since ancient...
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The ex vivo human translaminar autonomous system to study spaceflight associated neuro-ocular syndrome pathogenesis
Spaceflight-Associated Neuro-ocular Syndrome (SANS) is a significant unexplained adverse reaction to long-duration spaceflight. We employ an ex vivo...
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Ophthalmology of Canidae: Foxes, Wolves, and Relatives
The diverse family Canidae has spread across many continents and contains species with different habitats and feeding behaviors. The family includes...
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Horticultural potential of chemical biology to improve adventitious rooting
The first reports that auxins promoted root formation in cuttings and that indole-3-butyric acid (IBA) was a particularly effective treatment date...
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Apelin C-Terminal Fragments: Biological Properties and Therapeutic Potential
AbstractCreation of bioactive molecules for treatment of cardiovascular diseases based on natural peptides is the focus of intensive experimental...
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Dissecting Light Sensing and Metabolic Pathways on the Millimeter Scale in High-Altitude Modern Stromatolites
Modern non-lithifying stromatolites on the shore of the volcanic lake Socompa (SST) in the Puna are affected by several extreme conditions. The...
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Structure and functional implications of photoreceptive systems in non-marine ostracods: a review
Ostracods are small, bivalved crustaceans living in all types of aquatic habitats. All non-marine species belong to the order Podocopida. They...
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Prokaryotic expression and characterization of artificial self-sufficient CYP120A monooxygenases
AbstractCytochrome P450 monooxygenases CYP120As are the unique non-membrane P450s, which are extensively involved in retinoid biodegradation. As the O ...
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Micro (mi) RNA and Diabetic Retinopathy
Diabetic Retinopathy (DR), a debilitating microvascular complication of diabetes, is one of the leading cause of blindness. However, the pathogenesis...
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Interactions between AT1R and GRKs: the determinants for activation of signaling pathways involved in blood pressure regulation
The success of Angiotensin II receptor blockers, specifically Angiotensin II type 1 receptor (AT1R) antagonists as antihypertensive drug emphasizes...
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Structure–function relationship and physiological role of apelin and its G protein coupled receptor
Apelin receptor (APJR) is a class A peptide (apelin) binding G protein-coupled receptor (GPCR) that plays a significant role in regulating blood...
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Effects of D2O and Deuteration on Biomembranes
Biological membranes not only delineate the barrier between the living cell and its surroundings to keep toxic substances out of the cell but also...