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Towards Stem/Progenitor Cell-Based Therapies for Retinal Degeneration
Retinal degeneration (RD) is a leading cause of blindness worldwide and includes conditions such as retinitis pigmentosa (RP), age-related macular...
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RNA Isolation from Human Stem Cell–Derived Retinal Organoids
RNA isolation is an essential first step for many types of molecular analyses, including reverse transcription PCR (RT-PCR)/quantitative RT-PCR...
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TRIM9 promotes Müller cell–derived retinal stem cells to differentiate into retinal ganglion cells by regulating Atoh7
Glaucoma is a multifactorial, irreversible blinding eye disease characterized by a large number of retinal ganglion cell (RGC) deaths. Müller...
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Peripheral monocytes and neutrophils promote photoreceptor cell death in an experimental retinal detachment model
Photoreceptor cell death and immune cell infiltration are two major events that contribute to retinal degeneration. However, the relationship between...
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Cell-based Therapies for Corneal and Retinal Disorders
Maintenance of the visual function is the desired outcome of ophthalmologic therapies. The shortcomings of the current treatment options, like...
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TREM2 deficiency in microglia accelerates photoreceptor cell death and immune cell infiltration following retinal detachment
Retinal detachment (RD) occurs in several major retinal conditions and often causes irreversible vision loss due to photoreceptor cell death. Retinal...
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Mechanisms contributing to inhibition of retinal ganglion cell death by cell permeable peptain-1 under glaucomatous stress
This study assesses the neuroprotective potential of CPP-P1, a conjugate of an anti-apoptotic peptain-1 (P1) and a cell-penetrating peptide (CPP) in...
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Application of Human Stem Cell Derived Retinal Organoids in the Exploration of the Mechanisms of Early Retinal Development
The intricate neural circuit of retina extracts salient features of the natural world and forms bioelectric impulse as the origin of vision. The...
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Mutant kri1l causes abnormal retinal development via cell cycle arrest and apoptosis induction
Damage to the ribosome or an imbalance in protein biosynthesis can lead to some human diseases, such as diabetic retinopathy (DR) and other eye...
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Boolean implication analysis of single-cell data predicts retinal cell type markers
BackgroundThe retina is a complex tissue containing multiple cell types that are essential for vision. Understanding the gene expression patterns of...
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Single-cell transcriptomes reveal a molecular link between diabetic kidney and retinal lesions
The occurrence of diabetic nephropathy (DN) and diabetic retinopathy (DR) are closely associated in patients with diabetes. However, the cellular and...
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New Perspectives in Stem Cell Transplantation and Associated Therapies to Treat Retinal Diseases: From Gene Editing to 3D Bioprinting
Inherited and non-inherited retinopathies can affect distinct cell types, leading to progressive cell death and visual loss. In the last years, new...
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The molecular mechanism of human stem cell-derived extracellular vesicles in retinal repair and regeneration
Extracellular vesicles (EVs), including microvesicles (MVs) and exosomes, play a critical role in metabolic regulation and intracellular...
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YTHDC1 aggravates high glucose-induced retinal vascular endothelial cell injury via m6A modification of CDK6
ObjectiveRetinal vascular endothelial cell (RVECs) injury is a major cause of morbidity and mortality among the patients with diabetes. RVECs...
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Inhibition of cGAS–STING pathway alleviates neuroinflammation-induced retinal ganglion cell death after ischemia/reperfusion injury
Acute glaucoma is a vision-threatening disease characterized by a sudden elevation in intraocular pressure (IOP), followed by retinal ganglion cell...
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Identifying Hmga2 preserving visual function by promoting a shift of Müller glia cell fate in mice with acute retinal injury
BackgroundUnlike in lower vertebrates, Müller glia (MG) in adult mammalian retinas lack the ability to reprogram into neurons after retinal injury or...
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Induced pluripotent stem cell–derived extracellular vesicles overexpressing SFPQ protect retinal Müller cells against hypoxia-induced injury
Splicing factor proline/glutamine-rich (SFPQ) is expressed in induced pluripotent stem cells (iPSCs), which are reported to orchestrate hypoxic...
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Role of mTORC1 activity during early retinal development and lamination in human-induced pluripotent stem cell‐derived retinal organoids
Retinal organoids derived from human-induced pluripotent stem cells (hiPSC) are powerful tools for studying retinal development as they model spatial...
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Stem cell therapy for inherited retinal diseases: a systematic review and meta-analysis
PurposeStem cell therapy is a promising therapeutic approach for inherited retinal diseases (IRDs). This study aims to quantitatively examine the...
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Stem cell sources and characterization in the development of cell-based products for treating retinal disease: An NEI Town Hall report
National Eye Institute recently issued a new Strategic Plan outlining priority research areas for the next 5 years. Starting cell source for deriving...