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A novel function of STAT3β in suppressing interferon response improves outcome in acute myeloid leukemia
Signal transducer and activator of transcription 3 (STAT3) is frequently overexpressed in patients with acute myeloid leukemia (AML). STAT3 exists in...
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Tryptophan alleviates chronic heat stress–induced impairment of antioxidant capacities, inflammatory response, and mitochondrial function in broilers
The aim of this study was to investigate the effect of dietary tryptophan (Trp) supplementation on serum biochemical indices, antioxidant indices,...
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Interaction with B-type lamin reveals the function of Drosophila Keap1 xenobiotic response factor in nuclear architecture
BackgroundThe Keap1-Nrf2 pathway serves as a central regulator that mediates transcriptional responses to xenobiotic and oxidative stimuli. Recent...
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The unfolded protein response unfolds
As a key organelle of protein targeting and secretion, the endoplasmic reticulum (ER) plays host to a wide variety of protein maturation steps...
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Soil fungal community structure and function response to rhizoma perennial peanut cultivars
BackgroundCrop-associated microorganisms play a crucial role in soil nutrient cycling, and crop growth, and health. Fine-scale patterns in soil...
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Stability of a diffusive-delayed HCV infection model with general cell-to-cell incidence function incorporating immune response and cell proliferation
In this work, we analyse the dynamics of a five-dimensional hepatitis C virus infection mathematical model including the spatial mobility of...
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Novel function of a putative TaCOBL ortholog associated with cold response
The plant COBRA protein family plays an important role in secondary cell wall biosynthesis and the orientation of cell expansion. The COBRA gene...
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Biological Function and Stress Response Mechanism of MYB Transcription Factor Family Genes
MYB transcription factors (TFs) are one of the largest TF families in plants. It can specifically bind with MYB cis-elements in the promoter region...
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Genome-wide identification of the TIFY family reveals JAZ subfamily function in response to hormone treatment in Betula platyphylla
BackgroundThe TIFY family is a plant-specific gene family and plays an important role in plant growth and development. But few reports have been...
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Assessment of cerebral autoregulatory function and inter-hemispheric blood flow in older adults with internal carotid artery stenosis using transcranial Doppler sonography-based measurement of transient hyperemic response after carotid artery compression
Unhealthy vascular aging promotes atherogenesis, which may lead to significant internal carotid artery stenosis (CAS) in 5 to 7.5% of older adults....
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Genome-wide identification of WRKY transcription factors in Casuarina equisetifolia and the function analysis of CeqWRKY11 in response to NaCl/NaHCO3 stresses
BackgroundCasuarina equisetifolia ( C. equisetifolia ) is a woody species with many excellent features. It has natural resistance against drought,...
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Geographically weighted regression estimation of the linear response and plateau function
The objective of this paper is to modify the linear geographically weighted regression (GWR) estimator to accommodate the discontinuous join point,...
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Signaling function of NH4+ in the activation of Fe-deficiency response in cucumber (Cucumis sativus L.)
Main conclusionNH 4 + is necessary for full functionality of reduction-based Fe deficiency response in plants.
AbstractNitrogen (N) is present in soil...
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Light Response Curves in Land Plants
Light is the driving force for photosynthesis. Two techniques are commonly employed to help characterize the relationship between the light...
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Evolution and function analysis of auxin response factors reveal the molecular basis of the developed root system of Zygophyllum xanthoxylum
BackgroundAs a xerophytic shrub, forming developed root system dominated with lateral roots is one of the effective strategies for Zygophyllum...
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Hesperidin Supplementation Improves Altered PON -1, LDL Oxidation, Inflammatory Response and Hepatic Function in an Experimental Rat Model of Hyperlipidemia
In this study, we have examined the effect of hesperidin on rats fed on an experimental high-fat diet. Male Wistar rats were given a high-fat diet...
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A pan-cancer analysis unveiling the function of NR4A family genes in tumor immune microenvironment, prognosis, and drug response
BackgroundNR4A family genes play crucial roles in cancers. However, the role of NR4A family genes in cancers remains paradoxical as they promote or...
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Function and Regulation of Aquatic Adventitious Roots
Severe flooding can lead to partial or complete submergence of the shoot, which is an adverse situation triggering a number of responses by the...
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Poly(ADP-ribosyl)ation of acetyltransferase NAT10 by PARP1 is required for its nucleoplasmic translocation and function in response to DNA damage
BackgroundN-acetyltransferase 10 (NAT10), an abundant nucleolar protein with both lysine and RNA cytidine acetyltransferase activities, has been...
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New insights into the emerging effects of inflammatory response on HDL particles structure and function
According to the increasing results, it has been well-demonstrated that the chronic inflammatory response, including systemic lupus erythematosus,...