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Longitudinal interrogation of sympathetic neural circuits and hemodynamics in preclinical models
Neurological disorders, including spinal cord injury, result in hemodynamic instability due to the disruption of supraspinal projections to the...
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Linking cerebral hemodynamics and ocular microgravity-induced alterations through an in silico-in vivo head-down tilt framework
Head-down tilt (HDT) has been widely proposed as a terrestrial analog of microgravity and used also to investigate the occurrence of...
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Integrated renal and sympathetic mechanisms underlying the development of sex- and age-dependent hypertension and the salt sensitivity of blood pressure
Aging is a non-modifiable understudied risk factor for hypertension. We hypothesized that sympathetically mediated activation of renal sodium...
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Role of Nitric Oxide in Structural Rearrangements in the Renal Medullary Interstitium When Modeling Hypothyroidism in Rats with Different Blood Vasopressin Levels
AbstractThe role of the renal autocoid, nitric oxide (NO), in the mechanism of structural rearrangements in the renal medullary...
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A multiple-metabolites model to predict preliminary renal injury induced by iodixanol based on UHPLC/Q-Orbitrap-MS and 1H-NMR
Background & aimsThere are some problems, such as unclear pathological mechanism, delayed diagnosis, and inaccurate therapeutic target of...
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Eltroxin and Hesperidin mitigate testicular and renal damage in hypothyroid rats: amelioration of oxidative stress through PPARγ and Nrf2/HO-1 signaling pathway
BackgroundThyroid hormones (THs) regulate growth, development and function of different tissues. Hypothyroidism is a common clinical disorder...
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Impact of knockout of dual-specificity protein phosphatase 5 on structural and mechanical properties of rat middle cerebral arteries: implications for vascular aging
Vascular aging influences hemodynamics, elevating risks for vascular diseases and dementia. We recently demonstrated that knockout (KO) of Dusp5 ...
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Effect of Vasopressin V1a Receptor Blockade on Renal Osmoregulatory Function in L-Thyroxine-Induced Hyperthyroid Rats with Different Blood Vasopressin Levels
AbstractThe effect of V 1a receptor (V 1a R) blockade on the renal osmoregulatory function was studied in WAG and Brattleboro rats under...
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A novel clinical diagnostic marker predicting the relationship between visceral adiposity and renal function evaluated by estimated glomerular filtration rate (eGFR) in the Chinese physical examination population
Background and aimsThe effect of body fat deposition on the kidney has received increasing attention. The Chinese visceral adiposity index (CVAI) is...
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Effect of NO Synthesis Blockade on Renal Osmoregulatory Function in Methimazole-Induced Hypothyroid Rats with Different Vasopressin Blood Level
AbstractWe studied the effect of blockade of NO synthesis on the renal osmoregulatory function in methimazole-induced hypothyroid WAG...
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Efficacy of Human Embryonic Stem Cells Compared to Adipose Tissue-Derived Human Mesenchymal Stem/Stromal Cells for Repair of Murine Post-Stenotic Kidneys
Clinical translation of mesenchymal stem/stromal cell (MSC) therapy has been impeded by the heterogenous nature and limited replicative potential of...
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Decoding the multicellular ecosystem of vena caval tumor thrombus in clear cell renal cell carcinoma by single-cell RNA sequencing
BackgroundVascular invasion with tumor thrombus frequently occurs in advanced renal cell carcinoma (RCC). Thrombectomy is one of the most challenging...
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Targeting mPGES-2 to protect against acute kidney injury via inhibition of ferroptosis dependent on p53
Acute kidney injury (AKI) is a clinical syndrome with high morbidity and mortality but no specific therapy. Microsomal prostaglandin E synthase-2...
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Mitochondrial metabolic reprogramming in diabetic kidney disease
Diabetic kidney disease, known as a glomerular disease, arises from a metabolic disorder impairing renal cell function. Mitochondria, crucial...
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Renoprotective effects of empagliflozin in type 1 and type 2 models of diabetic nephropathy superimposed with hypertension
Diabetes, hypertension, and aging are major contributors to cardiovascular and chronic kidney disease (CKD). Sodium/glucose cotransporter 2 (SGLT2)...
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Effect of Neurohypophysial Hormones on Protein Excretion by the Kidneys
AbstractVasopressin (VP) is one of the main factors affecting intraglomerular hemodynamics, filtration pressure, and the state of mesangial...
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Adiponectin protects against myocardial ischemia–reperfusion injury: a systematic review and meta-analysis of preclinical animal studies
BackgroundMyocardial ischemia–reperfusion injury (MIRI) is widespread in the treatment of ischemic heart disease, and its treatment options are...
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Drug induced nephrotoxicity- A mechanistic approach
The main goal of the treatment of patients is its effectiveness and safety. However, all currently prescribed drugs being used also have certain...
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A comparison between centrally and systemically administered erythropoietin on kidney protection in a model of fixed-volume hemorrhagic shock in male rats
BackgroundIn this study, a comparison between centrally and systemically administered erythropoietin (EPO) was performed on nephroprotection during...
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The Use of “Space” Electrical Myostimulation in Clinical Cardiology on Earth
AbstractThe article describes a series of studies of the efficacy of the method of electromyostimulation, developed under the leadership of Inesa...
