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  1. The Copper Efflux Regulator (CueR)

    The copper efflux regulator (CueR) is a classical member of the MerR family of metalloregulators and is common in gram-negative bacteria. Through its...
    Yangbo Hu, Bin Liu in Macromolecular Protein Complexes V
    Chapter 2024
  2. G2-LIKE CAROTENOID REGULATOR (SlGCR) is a positive regulator of lutein biosynthesis in tomato

    Lutein is an oxygen-containing carotenoid synthesized in plant chloroplasts and chromoplasts. It plays an indispensable role in promoting plant...

    Siyan Ren, Yong Yuan, ... Yang Zhang in aBIOTECH
    Article Open access 29 November 2022
  3. Chromatin regulator SMARCAL1 modulates cellular lipid metabolism

    Biallelic mutations of the chromatin regulator SMARCAL1 cause Schimke Immunoosseous Dysplasia (SIOD), characterized by severe growth defects and...

    Taylor Hanta Nagai, Chrissy Hartigan, ... Yu-**n Xu in Communications Biology
    Article Open access 21 December 2023
  4. Crosstalk of TetR-like regulator SACE_4839 and a nitrogen regulator for erythromycin biosynthesis

    Abstract

    TetR family transcriptional regulators (TFRs) are widespread in actinomycetes, which exhibit diverse regulatory modes in antibiotic...

    Sabir Khan, Xueqi Xu, ... Buchang Zhang in Applied Microbiology and Biotechnology
    Article 09 September 2022
  5. Star Anise Extract As a Plant Growth Regulator

    Abstract

    Currently, much attention is being paid to reducing the use of chemical plant protection products and increasing the use of natural growth...

    V. V. Taranenko, I. G. Dmitrieva, V. S. Muravyov in Russian Agricultural Sciences
    Article 01 December 2023
  6. Cell death dependent on holins LrgAB repressed by a novel ArsR family regulator CdsR

    The cell death and survival paradox in various biological processes requires clarification. While spore development causes maternal cell death in Bacillus...

    Article Open access 11 April 2024
  7. Unveiling the repressive mechanism of a PPS-like regulator (PspR) in polyhydroxyalkanoates biosynthesis network

    Abstract

    Poly(3-hydroxybutyrate- co -3-hydroxyvalerate) (PHBV) is a type of polyhydroxyalkanoates (PHA) that exhibits numerous outstanding properties...

    Junyu Chen, Yinglu Cui, ... Hua **ang in Applied Microbiology and Biotechnology
    Article Open access 18 March 2024
  8. mTORC2: a multifaceted regulator of autophagy

    Abstract

    Autophagy is a multi-step catabolic process that delivers cellular components to lysosomes for degradation and recycling. The dysregulation...

    Yanan Sun, Huihui Wang, ... Yixuan Li in Cell Communication and Signaling
    Article Open access 05 January 2023
  9. ZBTB7B is a permissive regulator of hepatocellular carcinoma initiation by repressing c-Jun expression and function

    Hepatocarcinogenesis is a multi-step process. However, the regulators of hepatocellular carcinoma (HCC) initiation are understudied. Adult...

    Yue Zhu, Qinqin Wang, ... Gaoxiang Ge in Cell Death & Disease
    Article Open access 15 January 2024
  10. Epigenomic analyses identify FOXM1 as a key regulator of anti-tumor immune response in esophageal adenocarcinoma

    Unlike most cancer types, the incidence of esophageal adenocarcinoma (EAC) has rapidly escalated in the western world over recent decades. Using...

    Benjamin Ziman, Qian Yang, ... De-Chen Lin in Cell Death & Disease
    Article Open access 19 February 2024
  11. A Mitochondrial Localized Chaperone Regulator OsBAG6 Functions in Saline-Alkaline Stress Tolerance in Rice

    B-cell lymphoma 2 (Bcl-2)-associated athanogene (BAG) family genes play prominent roles in regulating plant growth, development, and stress response....

    Jie Wang, Min Ao, ... Zheng-Yi Xu in Rice
    Article Open access 22 January 2024
  12. High-throughput functional screen identifies YWHAZ as a key regulator of pancreatic cancer metastasis

    Pancreatic cancer is a leading cause of cancer death due to its early metastasis and limited response to the current therapies. Metastasis is a...

    Fang Cao, Yunpeng Jiang, ... Kailong Li in Cell Death & Disease
    Article Open access 14 July 2023
  13. USP18 is an essential regulator of muscle cell differentiation and maturation

    The ubiquitin proteasomal system is a critical regulator of muscle physiology, and impaired UPS is key in many muscle pathologies. Yet, little is...

    Cyriel Sebastiaan Olie, Adán Pinto-Fernández, ... Benedikt M. Kessler in Cell Death & Disease
    Article Open access 31 March 2023
  14. Biofortification of Iron in Potato Through Rhizobacteria and Plant Growth Regulator

    Millions of people around the world have iron deficiency, which is one of several important nutritional disorders. Despite recent advances in the...

    Zain Mushtaq, Ibrahim Al-Ashkar, ... Predrag Ilić in Potato Research
    Article 26 October 2023
  15. TBC1D1 is an energy-responsive polarization regulator of macrophages via governing ROS production in obesity

    Energy status is linked to the production of reactive oxygen species (ROS) in macrophages, which is elevated in obesity. However, it is unclear how...

    Qi Wang, ** Rong, ... Shuai Chen in Science China Life Sciences
    Article 14 June 2024
  16. SVEN_5003 is a Major Developmental Regulator in Streptomyces venezuelae

    Many regulatory genes that affect cellular development in Streptomyces , such as the canonical bld genes, have already been identified. However, in...

    Yan** Zhu, Ting Lu, ... **uhua Pang in Current Microbiology
    Article 09 May 2024
  17. TrichomeLess Regulator 3 is required for trichome initial and cuticle biosynthesis in Artemisia annua

    Artemisinin is primarily synthesized and stored in the subepidermal space of the glandular trichomes of Artemisia annua . The augmentation of trichome...

    Boran Dong, Zihan Xu, ... Wansheng Chen in Molecular Horticulture
    Article Open access 19 March 2024
  18. OsRR26, a type-B response regulator, modulates salinity tolerance in rice via phytohormone-mediated ROS accumulation in roots and influencing reproductive development

    Main Conclusion

    OsRR26 is a cytokinin-responsive response regulator that promotes phytohormone-mediated ROS accumulation in rice roots, regulates...

    Ramsong Chantre Nongpiur, Nishtha Rawat, ... Ashwani Pareek in Planta
    Article 22 March 2024
  19. Type-B response regulator OsRR22 forms a transcriptional activation complex with OsSLR1 to modulate OsHKT2;1 expression in rice

    Soil salinity severely limits crop yields and quality. Plants have evolved several strategies to mitigate the adverse effects of salinity, including...

    Yutong Liu, **aoyuan Peng, ... Zheng-Yi Xu in Science China Life Sciences
    Article 30 October 2023
  20. Protein regulator of cytokinesis 1 accentuates cholangiocarcinoma progression via mTORC1-mediated glycolysis

    This study aimed to investigate the expression of protein regulator of cytokinesis 1 (PRC1) in cholangiocarcinoma (CHOL) and elucidate its potential...

    Chao Zhang, Chengkun Qin in Human Cell
    Article 28 February 2024
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