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The Copper Efflux Regulator (CueR)
The copper efflux regulator (CueR) is a classical member of the MerR family of metalloregulators and is common in gram-negative bacteria. Through its... -
G2-LIKE CAROTENOID REGULATOR (SlGCR) is a positive regulator of lutein biosynthesis in tomato
Lutein is an oxygen-containing carotenoid synthesized in plant chloroplasts and chromoplasts. It plays an indispensable role in promoting plant...
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Chromatin regulator SMARCAL1 modulates cellular lipid metabolism
Biallelic mutations of the chromatin regulator SMARCAL1 cause Schimke Immunoosseous Dysplasia (SIOD), characterized by severe growth defects and...
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Crosstalk of TetR-like regulator SACE_4839 and a nitrogen regulator for erythromycin biosynthesis
AbstractTetR family transcriptional regulators (TFRs) are widespread in actinomycetes, which exhibit diverse regulatory modes in antibiotic...
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Star Anise Extract As a Plant Growth Regulator
AbstractCurrently, much attention is being paid to reducing the use of chemical plant protection products and increasing the use of natural growth...
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Cell death dependent on holins LrgAB repressed by a novel ArsR family regulator CdsR
The cell death and survival paradox in various biological processes requires clarification. While spore development causes maternal cell death in Bacillus...
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Unveiling the repressive mechanism of a PPS-like regulator (PspR) in polyhydroxyalkanoates biosynthesis network
AbstractPoly(3-hydroxybutyrate- co -3-hydroxyvalerate) (PHBV) is a type of polyhydroxyalkanoates (PHA) that exhibits numerous outstanding properties...
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mTORC2: a multifaceted regulator of autophagy
AbstractAutophagy is a multi-step catabolic process that delivers cellular components to lysosomes for degradation and recycling. The dysregulation...
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ZBTB7B is a permissive regulator of hepatocellular carcinoma initiation by repressing c-Jun expression and function
Hepatocarcinogenesis is a multi-step process. However, the regulators of hepatocellular carcinoma (HCC) initiation are understudied. Adult...
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Epigenomic analyses identify FOXM1 as a key regulator of anti-tumor immune response in esophageal adenocarcinoma
Unlike most cancer types, the incidence of esophageal adenocarcinoma (EAC) has rapidly escalated in the western world over recent decades. Using...
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A Mitochondrial Localized Chaperone Regulator OsBAG6 Functions in Saline-Alkaline Stress Tolerance in Rice
B-cell lymphoma 2 (Bcl-2)-associated athanogene (BAG) family genes play prominent roles in regulating plant growth, development, and stress response....
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High-throughput functional screen identifies YWHAZ as a key regulator of pancreatic cancer metastasis
Pancreatic cancer is a leading cause of cancer death due to its early metastasis and limited response to the current therapies. Metastasis is a...
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USP18 is an essential regulator of muscle cell differentiation and maturation
The ubiquitin proteasomal system is a critical regulator of muscle physiology, and impaired UPS is key in many muscle pathologies. Yet, little is...
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Biofortification of Iron in Potato Through Rhizobacteria and Plant Growth Regulator
Millions of people around the world have iron deficiency, which is one of several important nutritional disorders. Despite recent advances in the...
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TBC1D1 is an energy-responsive polarization regulator of macrophages via governing ROS production in obesity
Energy status is linked to the production of reactive oxygen species (ROS) in macrophages, which is elevated in obesity. However, it is unclear how...
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SVEN_5003 is a Major Developmental Regulator in Streptomyces venezuelae
Many regulatory genes that affect cellular development in Streptomyces , such as the canonical bld genes, have already been identified. However, in...
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TrichomeLess Regulator 3 is required for trichome initial and cuticle biosynthesis in Artemisia annua
Artemisinin is primarily synthesized and stored in the subepidermal space of the glandular trichomes of Artemisia annua . The augmentation of trichome...
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OsRR26, a type-B response regulator, modulates salinity tolerance in rice via phytohormone-mediated ROS accumulation in roots and influencing reproductive development
Main ConclusionOsRR26 is a cytokinin-responsive response regulator that promotes phytohormone-mediated ROS accumulation in rice roots, regulates...
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Type-B response regulator OsRR22 forms a transcriptional activation complex with OsSLR1 to modulate OsHKT2;1 expression in rice
Soil salinity severely limits crop yields and quality. Plants have evolved several strategies to mitigate the adverse effects of salinity, including...
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Protein regulator of cytokinesis 1 accentuates cholangiocarcinoma progression via mTORC1-mediated glycolysis
This study aimed to investigate the expression of protein regulator of cytokinesis 1 (PRC1) in cholangiocarcinoma (CHOL) and elucidate its potential...