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Selection of favorable alleles of genes controlling flowering and senescence improves malt barley quality
Malt barley ( Hordeum vulgare L.) is an important cash crop with stringent grain quality standards. Timing of the switch from vegetative to...
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Combined effects of a glycine-rich RNA-binding protein and a NAC transcription factor extend grain fill duration and improve malt barley agronomic performance
Key messageTwo key barley genes independently control anthesis and senescence timing, enabling the manipulation of grain fill duration, grain...
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Syncytium Induced by Plant-Parasitic Nematodes
Plant-parasitic nematodes from the genera Globodera, Heterodera (cyst-forming nematodes), and Meloidogyne (root-knot nematodes) are notorious and...
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The multifaceted role of Fragile X-Related Protein 1 (FXR1) in cellular processes: an updated review on cancer and clinical applications
RNA-binding proteins (RBPs) modulate the expression level of several target RNAs (such as mRNAs) post-transcriptionally through interactions with...
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The Retinoblastoma Gene Family in Cell Cycle Regulation and Suppression of Tumorigenesis
Since its discovery in 1986, as the first tumor suppressor gene, the retinoblastoma gene (Rb) has been extensively studied. Numerous biochemical and...
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Transcriptome analysis reveals differentially expressed genes between the ovary and testis of the honey bee Apis mellifera
Honey bees ( Apis mellifera ) are an important social pollinator, crucial in maintaining ecological balance and biodiversity. The haploid-diploid sex...
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Structure of the p53/RNA polymerase II assembly
The tumor suppressor p53 protein activates expression of a vast gene network in response to stress stimuli for cellular integrity. The molecular...
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PRC1 drives Polycomb-mediated gene repression by controlling transcription initiation and burst frequency
The Polycomb repressive system plays a fundamental role in controlling gene expression during mammalian development. To achieve this, Polycomb...
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A dual role for H2A.Z.1 in modulating the dynamics of RNA polymerase II initiation and elongation
RNA polymerase II (RNAPII) pausing immediately downstream of the transcription start site is a critical rate-limiting step for the expression of most...
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Predicting the Outcome of Arsenic Toxicity on Exposed Juvenile Male-Humans: A Shift to Infertility
Toxicity caused by arsenic ingestion on the health of the human male reproductive axis has been researched upon. Numerous pathways linking arsenic...
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Phase Separation Orchestrates Cancer Signaling: Stress Granules as a Promising Target for Cancer Therapy
Liquid–liquid phase separation (LLPS) has recently emerged as a new fundamental mechanism for the eukaryotic cellular organization via the formation...
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The genome of the zoonotic malaria parasite Plasmodium simium reveals adaptations to host switching
BackgroundPlasmodium simium , a malaria parasite of non-human primates (NHP), was recently shown to cause zoonotic infections in humans in Brazil. We...
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CDK9 inhibition as an effective therapy for small cell lung cancer
Treatment-naïve small cell lung cancer (SCLC) is typically susceptible to standard-of-care chemotherapy consisting of cisplatin and etoposide...
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Modeling Cell Cycle Control and Cancer with pRB Tumor Suppressor
Cancer is a complex syndrome of diseases characterized by the increased abundance of cells that disrupts the normal tissue architecture within...
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Allelic to genome wide perspectives of swine genetic variation to litter size and its component traits
Litter size is a complex and sex limited trait that depends on various biological, managemental and environmental factors. Owing to its low...
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Combinatorial control of Spo11 alternative splicing by modulation of RNA polymerase II dynamics and splicing factor recruitment during meiosis
Homologous recombination and chromosome segregation in meiosis rely on the timely expression of two splice variants of the endonuclease SPO11, named...
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A cohesin traffic pattern genetically linked to gene regulation
Cohesin-mediated loop extrusion has been shown to be blocked at specific cis -elements, including CTCF sites, producing patterns of loops and domain...
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Genomic regulation of transcription and RNA processing by the multitasking Integrator complex
In higher eukaryotes, fine-tuned activation of protein-coding genes and many non-coding RNAs pivots around the regulated activity of RNA polymerase...
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Integrated analyses of miRNA-mRNA expression profiles of ovaries reveal the crucial interaction networks that regulate the prolificacy of goats in the follicular phase
BackgroundLitter size is an important index of mammalian prolificacy and is determined by the ovulation rate. The ovary is a crucial organ for...
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Mechanisms of lncRNA biogenesis as revealed by nascent transcriptomics
Mammalian genomes express two principal gene categories through RNA polymerase II-mediated transcription: protein-coding transcription units and...
