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Targeting the cytochrome bc1 complex for drug development in M. tuberculosis: review
The terminal oxidases of the oxidative phosphorylation pathway play a significant role in the survival and growth of M. tuberculosis , targeting these...
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The cytochrome b6f complex: plastoquinol oxidation and regulation of electron transport in chloroplasts
In oxygenic photosynthetic systems, the cytochrome b 6 f (Cyt b 6 f ) complex (plastoquinol:plastocyanin oxidoreductase) is a heart of the hub that...
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New chemical fungicides in relation to risk for resistance development
Fungicides have played a key role in crop disease control worldwide. However, resistance development in pathogen populations became a serious concern...
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The therapeutic potential of mitochondrial toxins
When screening active compounds by phenotypic assays, we often encounter mitochondrial toxins, which are compounds that can affect mitochondrial...
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Identification of a New Isoindole-2-yl Scaffold as a Qo and Qi Dual Inhibitor of Cytochrome bc 1 Complex: Virtual Screening, Synthesis, and Biochemical Assay
Respiratory chain ubiquinol–cytochrome (cyt) c oxidoreductase (cyt bc 1 or complex III) has been demonstrated as a promising target for numerous...
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Cryo-EM structure of the respiratory I + III2 supercomplex from Arabidopsis thaliana at 2 Å resolution
Protein complexes of the mitochondrial respiratory chain assemble into respiratory supercomplexes. Here we present the high-resolution electron...
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Generation of Electric Potential Difference by Chromatophores from Photosynthetic Bacteria in the Presence of Trehalose under Continuous Illumination
AbstractMeasurement of electrical potential difference (Δψ) in membrane vesicles (chromatophores) from the purple bacterium Rhodobacter sphaeroides ...
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Fungicide Resistance: Threats and Management Approaches
Fungal pathogens are responsible for significant reduction of crop yield globally when left untreated. The spread of fungal diseases can be...
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Quinolone: a versatile therapeutic compound class
The discovery of nalidixic acid is one pinnacle in medicinal chemistry, which opened a new area of research that has led to the discovery of several...
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An ETFDH-driven metabolon supports OXPHOS efficiency in skeletal muscle by regulating coenzyme Q homeostasis
Coenzyme Q (Q) is a key lipid electron transporter, but several aspects of its biosynthesis and redox homeostasis remain undefined. Various...
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Using a chimeric respiratory chain and EPR spectroscopy to determine the origin of semiquinone species previously assigned to mitochondrial complex I
BackgroundFor decades, semiquinone intermediates have been suggested to play an essential role in catalysis by one of the most enigmatic...
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Effect of Melatonin and Salicylic Acid on ROS Generation by Mitochondria of Lupine Seedlings
AbstractThe effect of melatonin and salicylic acid (SA) on respiration and ROS (hydrogen peroxide) generation during the oxidation of succinate by...
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The potential of respiration inhibition as a new approach to combat human fungal pathogens
The respiratory chain has been proposed as an attractive target for the development of new therapies to tackle human fungal pathogens. This arises...
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Modelling mitochondrial ROS production by the respiratory chain
ROS (superoxide and oxygen peroxide in this paper) play a dual role as signalling molecules and strong oxidizing agents leading to oxidative stress....
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Synthetic Chemicals: Major Component of Plant Disease Management
Direct protection using synthetic chemicals is one of the basic principles of plant disease management. Historical perspectives of using chemicals...
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Research journey of respirasome
Respirasome, as a vital part of the oxidative phosphorylation system, undertakes the task of transferring electrons from the electron donors to...
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Impact of antimycin A and myxothiazol on cadmium-induced superoxide, hydrogen peroxide, and nitric oxide generation in barley root tip
In order to gain more insight into the involvement of mitochondrial complex III in the Cd-induced stress, we studied the effect of complex III...
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Baseline sensitivity and resistance risk assessment of Valsa mali to pyraclostrobin
Pyraclostrobin, a quinone outside inhibitor (QoI) fungicide, has been registered to control apple tree Valsa canker (AVC) caused by Valsa mali in...
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Chemical Pesticides: Integrated Methods in Assessment and Monitoring
Pesticides are the substances which are employed to kill, repel or control the pests, weeds, plant pathogens and the diseases caused by them. The...
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