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1. ADAMTS4 is a crucial proteolytic enzyme for versican cleavage in the amnion at parturition

   Hyalectan cleavage may play an important role in extracellular matrix remodeling. However, the proteolytic enzyme responsible for hyalectan...

   Meng-Die Li, Jiang-Wen Lu, ... Kang Sun in Communications Biology

   Article Open access 09 March 2024
   

2. Intrauterine botulinum toxin A administration promotes endometrial regeneration mediated by IGFBP3-dependent OPN proteolytic cleavage in thin endometrium

   Adequate endometrial growth is a critical factor for successful embryo implantation and pregnancy maintenance. We previously reported the efficacy of...

   Danbi Lee, Jungho Ahn, ... Youn-Jung Kang in Cellular and Molecular Life Sciences

   Article Open access 05 January 2023
   

3. AKT phosphorylation as a predictive biomarker for PI3K/mTOR dual inhibition-induced proteolytic cleavage of mTOR companion proteins in small cell lung cancer

   Background

   Constitutive activation of PI3K signaling has been well recognized in a subset of small cell lung cancer (SCLC), the cancer type which has...

   Ming-Chun Hung, Wan-** Wang, Ya-Hui Chi in Cell & Bioscience

   Article Open access 02 August 2022
   

4. Characterization of Phytaspase Proteolytic Activity Using Fluorogenic Peptide Substrates

   Within the subtilase family of plant proteolytic enzymes, phytaspases are distinguished by their strict substrate cleavage specificity after an...

   Raisa A. Galiullina, Nina V. Chichkova, ... Andrey B. Vartapetian in Plant Peptide Hormones and Growth Factors

   Protocol 2024
   

5. Proteolytic activation of fatty acid synthase signals pan-stress resolution

   Chronic stress and inflammation are both outcomes and major drivers of many human diseases. Sustained responsiveness despite mitigation suggests a...

   Hai Wei, Yi M. Weaver, ... Benjamin P. Weaver in Nature Metabolism

   Article Open access 02 January 2024
   

6. Double Covalent Bonding of Biliverdin in Near-Infrared Fluorescent Proteins Prevents Their Proteolytic Degradation

   Abstract

   In this work, we analyzed how the double covalent binding of the biliverdin ligand (BV) in the near-infrared fluorescent protein iRFP670...

   Olga V. Stepanenko, Olesya V. Stepanenko in Cell and Tissue Biology

   Article 05 June 2023
   

7. Full-length GSDME mediates pyroptosis independent from cleavage

   Gasdermin (GSDM) family proteins, known as the executors of pyroptosis, undergo protease-mediated cleavage before inducing pyroptosis. We here...

   Bo Zhou, Zhi-hong Jiang, ... Qiao Wu in Nature Cell Biology

   Article 12 July 2024
   

8. Caspase cleavage of RIPK3 after Asp³³³ is dispensable for mouse embryogenesis

   The proteolytic activity of caspase-8 suppresses lethal RIPK1-, RIPK3- and MLKL-dependent necroptosis during mouse embryogenesis. Caspase-8 is...

   Kim Newton, Katherine E. Wickliffe, ... Vishva M. Dixit in Cell Death & Differentiation

   Article Open access 08 January 2024
   

9. Proteolytic inactivation of CXCL12 in the lungs and circulation of COVID-19 patients

   The human chemokine stromal cell-derived factor-1 (SDF-1) or CXCL12 is involved in several homeostatic processes and pathologies through interaction...

   Seppe Cambier, Fabio Beretta, ... Paul Proost in Cellular and Molecular Life Sciences

   Article 28 July 2023
   

10. Map** and functional characterization of murine kidney injury molecule-1 proteolytic cleavage site

    Kidney injury molecule-1 (KIM-1), also known as T cell immunoglobulin and mucin domain 1 (TIM-1), is a transmembrane glycoprotein expressed on...

    Saranga Sriranganathan, Elena Tutunea-Fatan, ... Lakshman Gunaratnam in Molecular and Cellular Biochemistry

    Article 19 November 2020
    

11. Effects of presenilin-1 familial Alzheimer’s disease mutations on γ-secretase activation for cleavage of amyloid precursor protein

    Presenilin-1 (PS1) is the catalytic subunit of γ-secretase which cleaves within the transmembrane domain of over 150 peptide substrates. Dominant...

    Hung N. Do, Sujan Devkota, ... Yinglong Miao in Communications Biology

    Article Open access 14 February 2023
    

12. Inducing Pyroptosis via Gasdermin B and Gasdermin E Cleavage

    Gasdermin B (GSDMB) and gasdermin E (GSDME) are two members of the gasdermin family, which shares a conservative gasdermin-N domain capable of...

    Zhiwei Zhou, Yupeng Wang, Feng Shao in Pyroptosis

    Protocol 2023
    

13. Antagonizing the irreversible thrombomodulin-initiated proteolytic signaling alleviates age-related liver fibrosis via senescent cell killing

    Cellular senescence is a stress-induced, stable cell cycle arrest phenotype which generates a pro-inflammatory microenvironment, leading to chronic...

    Christopher C. Pan, Raquel Maeso-Díaz, ... **ao-Fan Wang in Cell Research

    Article 11 May 2023
    

14. Cleavage of cell junction proteins as a host invasion strategy in leptospirosis

    Abstract

    Infection and invasion are the prerequisites for develo** the disease symptoms in a host. While the probable mechanism of host invasion and...

    Preeti Kumari, Suhani Yadav, ... Padikara K. Satheeshkumar in Applied Microbiology and Biotechnology

    Article Open access 10 January 2024
    

15. Profiling Sequence Specificity of Proteolytic Activities Using Proteome-Derived Peptide Libraries

    Substrate sequence specificity is a fundamental characteristic of proteolytic enzymes. Hundreds of proteases are encoded in plant genomes, but the...

    Fatih Demir, Maithreyan Kuppusamy, ... Pitter F. Huesgen in Plant Proteases and Plant Cell Death

    Protocol 2022
    

16. Adherens junctions organize size-selective proteolytic hotspots critical for Notch signalling

    Adherens junctions (AJs) create spatially, chemically and mechanically discrete microdomains at cellular interfaces. Here, using a mechanogenetic...

    Minsuk Kwak, Kaden M. Southard, ... Young-wook Jun in Nature Cell Biology

    Article 01 December 2022
    

17. Caspase-9-mediated cleavage of vimentin attenuates the aggressiveness of leukemic NB4 cells

    Vimentin is a main type 3 intermediate filament protein. It seems that abnormal expression of vimentin is contributed to the appearance of the...

    Fatemeh Hakim, Cyrus Kazemiraad, ... Saeed Mohammadi in Molecular and Cellular Biochemistry

    Article 18 February 2023
    

18. Proteolytic rewiring of mitochondria by LONP1 directs cell identity switching of adipocytes

    Mitochondrial proteases are emerging as key regulators of mitochondrial plasticity and acting as both protein quality surveillance and regulatory...

    Tingting Fu, Wan** Sun, ... Zhenji Gan in Nature Cell Biology

    Article 22 May 2023
    

19. Caprine PRNP polymorphisms N146S and Q222K are associated with proteolytic cleavage of PrP^C

    Expression of the cellular prion protein (PrP ^C ) is crucial for the development of prion diseases. Amino acid changes in PrP ^C or a reduced amount of...

    Sally A. Madsen-Bouterse, Paula Stewart, ... Wilfred Goldmann in Genetics Selection Evolution

    Article Open access 19 June 2021
    

20. Enhancing proteolytic activity of Lysobacter enzymogenes using cold atmospheric plasma

    Cold atmospheric plasma (CAP) is being used recently as a modern technique for microbial random mutagenesis. In the present study, CAP was used to...

    Faranak Faraji Tabar, Vahideh Valizadeh, ... Dariush Norouzian in Archives of Microbiology

    Article 20 May 2022