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Dietary Magnesium Intake and Proteinuria: Is There a Relationship?
The possible relationship between dietary magnesium status and proteinuria has been suggested by a number of previous studies. However, human studies...
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ANGPTL3 impacts proteinuria and hyperlipidemia in primary nephrotic syndrome
BackgroundIt is unclear why primary nephrotic syndrome (PNS) patients often have dyslipidemia. Recent studies have shown that angiopoietin-like...
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Microtubule associated protein 4 phosphorylation-induced epithelial-to-mesenchymal transition of podocyte leads to proteinuria in diabetic nephropathy
BackgroundDiabetic nephropathy (DN) involves various structural and functional changes because of chronic glycemic assault and kidney failure....
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Utility of non-HDL-C in predicting proteinuria remission of idiopathic membranous nephropathy: a retrospective cohort study
BackgroundIdiopathic membranous nephropathy (IMN) may have various clinical outcomes. Hyperlipidemia is quite common in IMN. However, the utility of...
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Growth hormone induces mitotic catastrophe of glomerular podocytes and contributes to proteinuria
Glomerular podocytes are integral members of the glomerular filtration barrier in the kidney and are crucial for glomerular permselectivity. These...
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Proteomic analyses reveal cystatin c is a promising biomarker for evaluation of systemic lupus erythematosus
BackgroundSystemic lupus erythematosus (SLE) is an autoimmune disease with multiple organ involvement, especially the kidneys. However, the...
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Minnelide combined with anti-ANGPTL3-FLD monoclonal antibody completely protects mice with adriamycin nephropathy by promoting autophagy and inhibiting apoptosis
Minimal change disease (MCD) is the common type of nephrotic syndrome (NS) in children. Currently, there is an urgent need to explore new treatments...
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Effect of Neurohypophysial Hormones on Protein Excretion by the Kidneys
AbstractVasopressin (VP) is one of the main factors affecting intraglomerular hemodynamics, filtration pressure, and the state of mesangial...
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Anti-ANGPTL3-FLD monoclonal antibody treatment ameliorates podocyte lesions through attenuating mitochondrial damage
Proteinuria, an indication of kidney disease, is caused by the malfunction of podocytes, which play a key role in maintaining glomerular filtration....
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Identification of immune-associated biomarkers of diabetes nephropathy tubulointerstitial injury based on machine learning: a bioinformatics multi-chip integrated analysis
BackgroundDiabetic nephropathy (DN) is a major microvascular complication of diabetes and has become the leading cause of end-stage renal disease...
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Metformin combined with rapamycin ameliorates podocyte injury in idiopathic membranous nephropathy through the AMPK/mTOR signaling pathway
Autophagy activation protects against podocyte injury in idiopathic membranous nephropathy (IMN). The AMPK/mTOR signaling pathway is a vital...
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Scutellarin ameliorates diabetic nephropathy via TGF-β1 signaling pathway
Breviscapine, a natural flavonoid mixture derived from the traditional Chinese herb Erigeron breviscapus (Vant.) Hand-Mazz, has demonstrated a...
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Angiopoietin-like protein 3 markedly enhanced in the hyperlipidemia related proteinuria
BackgroundAngiopoietin-like protein 3(ANGPTL3) is well acknowledged as a key regulator of lipid metabolism. Now, there have not been enough data to...
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Crosstalk among podocytes, glomerular endothelial cells and mesangial cells in diabetic kidney disease: an updated review
Diabetic kidney disease (DKD) is a long-term and serious complication of diabetes that affects millions of people worldwide. It is characterized by...
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Zyxin is important for the stability and function of podocytes, especially during mechanical stretch
Podocyte detachment due to mechanical stress is a common issue in hypertension-induced kidney disease. This study highlights the role of zyxin for...
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The Strategy for Peptidomic LC-MS/MS Data Analysis: The Case of Urinary Peptidome Study
The study of urinary peptidome is an important area of research, which concerns the characterization of endogenous peptides, as well as the...
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Effects of a novel ANLN E841K mutation associated with SRNS on podocytes and its mechanism
BackgroundSteroid-resistant nephrotic syndrome (SRNS) is characterized by unrelieved proteinuria after an initial 4–8 weeks of glucocorticoid...
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Renoprotective effects of empagliflozin in type 1 and type 2 models of diabetic nephropathy superimposed with hypertension
Diabetes, hypertension, and aging are major contributors to cardiovascular and chronic kidney disease (CKD). Sodium/glucose cotransporter 2 (SGLT2)...
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Preeclampsia: Early and Long-Term Clinical Considerations
Preeclampsia is a hypertensive disorder of pregnancy characterized by new onset of hypertension after 20 weeks gestational age, in the setting of...
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An Intriguing Case of Amyloidosis Leading to PAGE Kidney in a Post Renal Transplant Recipient: A Case Report
Amyloidosis is an infiltrative disease where amyloid fibrils get deposited in the organs like kidney, liver and spleen. Amyloid deposition in the...
