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ER Stress Decreases Gene Expression Of Transmembrane Protein 117 Via Activation of PKR-like ER Kinase
Stress response is an inherent mechanism in the endoplasmic reticulum (ER). The inducers of ER cause a specific cascade of reactions, leading to gene...
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Mitogen-Activated Protein Kinase: A Potent Signaling Protein that Combats Biotic and Abiotic Stress in Plants
Serine kinases, also identified as mitogen-activated protein kinases (MAPKs), are involved in the transmission of cellular signals that carry out...
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Protein kinase D2-Aurora kinase A-ERK1/2 signalling axis drives neuroendocrine differentiation of epithelial ovarian cancer
Epithelial ovarian cancer (EOC) is deadliest gynecological malignancy with poor prognosis and patient survival. Despite development of several...
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Conformational Transitions in EGFR Protein Tyrosine Kinase Domain and Their Modulation by Mutants
The epidermal growth factor receptor (EGFR) is a membrane protein with intracellular kinase activity. The EGFR plays a significant role in the cell...
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The Glycine Max Abscisic Acid-Activated Protein Kinase-Like Kinase 1 (GmAALK1) Modulates Drought Stress Response
Abscisic acid-activated protein kinases (AAPK) are key components in abscisic acid (ABA) signalling and have been implicated in mediating responses...
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Genome-wide identification and gene expression analysis of GHMP kinase gene family in banana cv. Rasthali
BackgroundThe GHMP kinase gene family encompasses ATP-dependent kinases, significantly involved in the biosynthesis of isoprenes, amino acids, and...
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Phototropin2 3’UTR overlaps with the AT5G58150 gene encoding an inactive RLK kinase
BackgroundThis study examines the biological implications of an overlap between two sequences in the Arabidopsis genome, the 3’UTR of the PHOT2 gene...
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Deletion of podocyte Rho-associated, coiled-coil-containing protein kinase 2 protects mice from focal segmental glomerulosclerosis
Focal segmental glomerulosclerosis (FSGS) shares podocyte damage as an essential pathological finding. Several mechanisms underlying podocyte injury...
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Genome-wide identification and expression analysis of the WNK kinase gene family in soybean
WNK kinases are a unique class of serine/threonine protein kinases that lack a conserved catalytic lysine residue in the kinase domain, hence the...
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Potential protein kinase inhibitors that target G-quadruplex DNA structures in the human telomeric regions
Telomeric regions contain Guanine-rich sequences arranged in a planar manner and connected by Hoogsteen hydrogen bonds that can fold into...
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A resource database for protein kinase substrate sequence-preference motifs based on large-scale mass spectrometry data
BackgroundProtein phosphorylation is one of the most prevalent posttranslational modifications involved in molecular control of cellular processes,...
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Kaposi’s sarcoma-associated herpesvirus viral protein kinase augments cell survival
Oncogenic viruses have developed various strategies to antagonize cell death and maintain lifelong persistence in their host, a relationship that may...
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Assessing the gene expression of the adenosine 5′-monophosphate-activated protein kinase (AMPK) and its relation with the IL-6 and IL-10 plasma levels in COVID-19 patients
BackgroundMetabolic dysregulation and excessive inflammation are implicated in the pathogenesis of the highly infectious disease of coronavirus...
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Genome-wide identification of the mitogen-activated protein kinase kinase kinase (MAPKKK) in pear (Pyrus bretschneideri) and their functional analysis in response to black spot
Main conclusionIdentification of MAPKKK genes in pear and functional characterization of PbrMAPKKK82 in response to pear black spot.
Abstract ...
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Current knowledge about FLT3 gene mutations, exploring the isoforms, and protein importance in AML
Acute myeloid leukaemia (AML) is a complex haematological malignancy characterised by diverse genetic alterations leading to abnormal proliferation...
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Death associated protein kinase 1 predicts the prognosis and the immunotherapy response of various cancers
BackgroundDeath Associated Protein Kinase 1 (DAPK1) is a calcium/calmodulin-dependent serine/threonine kinase, which has been reported to be a tumor...
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Characterization of the pyruvate kinase gene family in soybean and identification of a putative salt responsive gene GmPK21
BackgroundAs a key regulatory enzyme in the glycolysis pathway, pyruvate kinase (PK) plays crucial roles in multiple physiological processes during...
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OsSTS, a Novel Allele of Mitogen-Activated Protein Kinase Kinase 4 (OsMKK4), Controls Grain Size and Salt Tolerance in Rice
Soil salinization is one of the most common abiotic stresses of rice, which seriously affects the normal growth of rice. Breeding salt-tolerant...
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Wall-Associated Kinase (WAK) and WAK-like Kinase Gene Family in Sugar Beet: Genome-Wide Characterization and In Silico Expression Analysis in Response to Beet Cyst Nematode (Heterodera schachtii Schmidt) Infection
The wall-associated kinase ( WAK ) and WAK-associated kinase-like ( WAKL ) genes belong to the major receptor-like kinase ( RLK ) gene family in plants....
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A zebrafish pparγ gene deletion reveals a protein kinase network associated with defective lipid metabolism
Peroxisome proliferator–activated receptor γ (Pparγ) is a master regulator of adipogenesis. Chronic pathologies such as obesity, cardiovascular...
