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A hybrid TIM complex mediates protein import into hydrogenosomes of Trichomonas vaginalis
BackgroundHydrogenosomes are a specific type of mitochondria that have adapted for life under anaerobiosis. Limited availability of oxygen has...
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Dissecting the molecular mechanisms of mitochondrial import and maturation of peroxiredoxins from yeast and mammalian cells
Peroxiredoxins (Prxs) are cysteine-based peroxidases that play a central role in kee** the H 2 O 2 at physiological levels. Eukaryotic cells express...
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Mitochondrien unter Stress: Die Rolle der Präsequenzprotease MPP
The majority of mitochondrial proteins are encoded in the nuclear genome, so that the nearly entire proteome is assembled by post-translational...
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Structural characterisation of a full-length mitochondrial outer membrane TOM40 preprotein translocase: implications for its interaction with presequence peptides
Tom40, the central component of the preprotein translocase of the mitochondrial outer membrane (TOM complex), forms the import pore that facilitates...
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Characterization of the Mitochondrial Proteome in the Ctenophore Mnemiopsis leidyi Using MitoPredictor
Mitochondrial proteomes have been experimentally characterized for only a handful of animal species. However, the increasing availability of genomic...
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Complex Endosymbioses I: From Primary to Complex Plastids, Serial Endosymbiotic Events
A considerable part of the diversity of eukaryotic phototrophs consists of algae with plastids that evolved from endosymbioses between two...
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Induce male sterility by CRISPR/Cas9-mediated mitochondrial genome editing in tobacco
Genome editing has become more and more popular in animal and plant systems following the emergence of CRISPR/Cas9 technology. However, target...
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Isolation and Quality Control of Yeast Mitochondria
The isolation of organelles devoid of other cellular compartments is crucial for studying organellar proteomes and the localization of newly...
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Quality control of proteins in the mitochondrion
The quality control of proteins within mitochondria is ensured by conserved and ubiquitous ATP-dependent molecular chaperones and proteases, present...
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Identification, cloning and characterization of AcMSH1 from Onion (Allium cepa L.)
BackgroundMSH1 (MutS homolog1) is a nuclear-encoded protein that plays a crucial role in maintaining low mutation rates and stability of the...
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Versatile biotechnological applications of Euglena gracilis
Euglena gracilis is a freshwater protist possessing secondary chloroplasts of green algal origin. Various physical factors (e.g. UV) and chemical...
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The mitochondrial carrier pathway transports non-canonical substrates with an odd number of transmembrane segments
BackgroundThe mitochondrial pyruvate carrier (MPC) plays a central role in energy metabolism by transporting pyruvate across the inner mitochondrial...
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Modular Assembly of Mitochondrial β-Barrel Proteins
Mitochondrial β-barrel proteins fulfill crucial roles in the biogenesis and function of the cell organelle. They mediate the import and membrane...
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MitoTALENs: A Method for Targeted Gene Disruption in Plant Mitochondrial Genomes
Modification of plant mitochondrial genomes is still a difficult task, especially in multicellular plants. Transcription activator-like effector...
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Decoding metabolic signatures in Alzheimer’s disease: a mitochondrial perspective
Alzheimer’s disease (AD) is one of the most prevalent age-related neurodegenerative diseases and accounts for the majority of dementia cases...
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Methods to Study the Biogenesis of Mitoribosomal Proteins in Yeast
The biogenesis of mitoribosomes is an intricate process that relies on the coordinated synthesis of nuclear-encoded mitoribosomal proteins (MRPs) in...
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NLG1, encoding a mitochondrial membrane protein, controls leaf and grain development in rice
BackgroundMitochondrion is the key respiratory organ and participate in multiple anabolism and catabolism pathways in eukaryote. However, the...
