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The PhoPR two-component system responds to oxygen deficiency and regulates the pathways for energy supply in Corynebacterium glutamicum
The PhoPR two-component system, a highly conserved system in corynebacteria and mycobacteria, is involved in the cellular response to environmental...
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Types and functions of heterogeneity in mycobacteria
The remarkable ability of Mycobacterium tuberculosis to survive attacks from the host immune response and drug treatment is due to the resilience of...
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The Response Regulator MacR and its Potential in Improvement of Antibiotic Production in Streptomyces coelicolor
We previously reported that the two-component system MacRS regulates morphogenesis and production of the blue-pigmented antibiotic actinorhodin (ACT)...
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Vaccines Against Tuberculosis: Problems and Prospects (Review)
AbstractDespite the efforts of the global medical and scientific community, tuberculosis remains the leading cause of death from infectious diseases....
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Taxonomic identification and temperature stress tolerance mechanisms of Aequorivita marisscotiae sp. nov
The deep sea harbours microorganisms with unique life characteristics and activities due to adaptation to particular environmental conditions, but...
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Structural and functional characterization of mycobacterial PhoH2 and identification of potential inhibitor of its enzymatic activity
Mycobacterium tuberculosis is composed of a cumbersome signaling and protein network which partakes in bacterial survival and augments its...
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Response to Phosphate Starvation and Osmotic Homeostasis
Phosphorus is one of the important nutrients for bacterial growth. Mostly, phosphorus is available in low concentrations in natural environment....
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Exploiting Fluorescent Proteins to Understand Mycobacterium tuberculosis Biology
The utility of fluorescent proteins in bacterial research has long been appreciated, with extensive use in the Mycobacterium tuberculosis field. In...
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Small RNAs of Mycobacterium tuberculosis in Adaptation to Host-Like Stress Conditions in vitro
AbstractThe regulatory mechanisms of pathogenic bacteria contribute to their survival under stress conditions in the host environment, which allows...
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Lipid droplets and the transcriptome of Mycobacterium tuberculosis from direct sputa: a literature review
Mycobacterium tuberculosis ( Mtb ), the main etiology of tuberculosis (TB), is predominantly an intracellular pathogen that has caused infection,...
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Small Noncoding RNAs and Their Role in the Pathogenesis of Mycobacterium tuberculosis Infection
AbstractMycobacterium tuberculosis possesses a significant arsenal of strategies to combat immune defense of the host organism. Small noncoding...
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Analysis of a bac operon-silenced strain suggests pleiotropic effects of bacilysin in Bacillus subtilis
Bacilysin, as the simplest peptide antibiotic made up of only L-alanine and L-anticapsin, is produced and excreted by Bacillus subtilis under the...
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Type VII secretion systems: structure, functions and transport models
Type VII secretion systems (T7SSs) have a key role in the secretion of effector proteins in non-pathogenic mycobacteria and pathogenic mycobacteria...
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Transposon libraries identify novel Mycobacterium bovis BCG genes involved in the dynamic interactions required for BCG to persist during in vivo passage in cattle
BackgroundBCG is the most widely used vaccine of all time and remains the only licensed vaccine for use against tuberculosis in humans. BCG also...
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Ecology and evolution of Mycobacterium tuberculosis
Tuberculosis (TB) is the number one cause of human death due to an infectious disease. The causative agents of TB are a group of closely related...
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Importance of differential identification of Mycobacterium tuberculosis strains for understanding differences in their prevalence, treatment efficacy, and vaccine development
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains a serious global health problem in the 21 st century because of its high...
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Mycobacterium tuberculosis Complex Members Adapted to Wild and Domestic Animals
The Mycobacterium tuberculosis complex (MTBC) is composed of several highly genetically related species that can be broadly classified into those...
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The Nature and Evolution of Genomic Diversity in the Mycobacterium tuberculosis Complex
The Mycobacterium tuberculosis Complex (MTBC) consists of a clonal group of several mycobacterial lineages pathogenic to a range of different...
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SMRT genome assembly corrects reference errors, resolving the genetic basis of virulence in Mycobacterium tuberculosis
BackgroundThe genetic basis of virulence in Mycobacterium tuberculosis has been investigated through genome comparisons of virulent (H37Rv) and...
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Functional Membrane Microdomains Organize Signaling Networks in Bacteria
Membrane organization is usually associated with the correct function of a number of cellular processes in eukaryotic cells as diverse as signal...
