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Effect of Galactooligosaccharide on PPARs/PI3K/Akt Pathway and Gut Microbiota in High-Fat and High-Sugar Diet Combined with STZ-Induced GDM Rat Model
Gestational diabetes mellitus (GDM) is a metabolic disorder, characterized by underlying glucose intolerance, diabetes onset or first diagnosis...
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A dietary anthocyanin cyanidin-3-O-glucoside binds to PPARs to regulate glucose metabolism and insulin sensitivity in mice
We demonstrate the mechanism by which C3G, a major dietary anthocyanin, regulates energy metabolism and insulin sensitivity. Oral administration of...
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Genome-wide identification and expression of the peroxisome proliferator-activated receptor gene family in the Tibetan highland fish Gymnocypris przewalskii
Peroxisome proliferator-activated receptor (PPAR) plays an important role in the regulation of lipid metabolism and has been widely identified in...
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Targeting lipid-sensing nuclear receptors PPAR (α, γ, β/δ): HTVS and molecular docking/dynamics analysis of pharmacological ligands as potential pan-PPAR agonists
The global prevalence of obesity-related systemic disorders, including non-alcoholic fatty liver disease (NAFLD), and cancers are rapidly rising....
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The cross-talk between leptin and circadian rhythm signaling proteins in physiological processes: a systematic review
BackgroundToday, modern lifestyles and disrupted sleep patterns cause circadian clock rhythm impairments that are associated with altered leptin...
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Effect of Anakinra on the Gene Expression of Receptors Activated by the Peroxisome Proliferator in the Rat Brain in the Lithium Pilocarpine Model of Epilepsy
AbstractThe role of neuroinflammation in the mechanisms of epileptogenesis has been widely discussed in recent years. One of the factors...
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Scintillation Proximity Assay (SPA)-Based Radioligand Binding for PPARα, PPARγ, and PPARδ Receptors
Peroxisome proliferator-activated receptors (PPARs) have been exploited as drug targets for combating multiple diseases. Several activators with...
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Coordinated transcriptional upregulation of oxidative metabolism proteins in long-lived endocrine mutant mice
Caloric restriction (CR), which extends lifespan in rodents, leads to increased hepatic fatty acid β-oxidation and oxidative phosphorylation...
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Effect of Cardarine on Gene Expression of Proteins Involved in Epileptogenesis in Rat Hippocampus in the Lithium-Pilocarpine Model of Temporal Lobe Epilepsy
AbstractDuring the last years, the role of astro- and microglial cells and associated neuroinflammation in the pathogenesis of epilepsy has been...
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The expression levels of PPAR-α/γ and UCP1/2 on the slow coronary flow phenomenon; results from a case–control study
PurposeThe slow coronary flow (SCF) phenomenon is considered a coronary artery disorder. Because of the critical function of peroxisome...
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Loss of Dec1 inhibits alcohol-induced hepatic lipid accumulation and circadian rhythm disorder
Chronic alcohol exposure increases liver damage such as lipid accumulation and hepatitis, resulting in hepatic cirrhosis. Chronic alcohol intake is...
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Ezetimibe promotes CYP7A1 and modulates PPARs as a compensatory mechanism in LDL receptor-deficient hamsters
BackgroundThe LDL-C lowering effect of ezetimibe has been attributed primarily to increased catabolism of LDL-C via up-regulation of LDL receptor...
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The Gut–Brain Axis and Peroxisome Proliferator-Activated Receptors in the Regulation of Epileptogenesis
AbstractA large proportion of patients with epilepsy suffer from pharmacoresistant forms of the disease, and this makes the search for new...
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Molecular Toxicity Mechanism of Plasticizers in the Reservoir
Plasticizers, due to their robustness, flexibility, and low production costs, have broad industrial applications. However, they are released into the...
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Metabolic Reprogramming of Anti-cancer T Cells: Targeting AMPK and PPAR to Optimize Cancer Immunotherapy
Cancer treatment era has been revolutionized by the novel therapeutic methods such as immunotherapy in recent years. Immunotherapy-based approaches...
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Immunology of gut microbiome and liver in non-alcoholic fatty liver disease (NAFLD): mechanisms, bacteria, and novel therapeutic targets
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the world. Most important contributors to its development are...
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Neuroprotective effects of the PPARβ/δ antagonist GSK0660 in in vitro and in vivo Parkinson’s disease models
BackgroundThe underlying mechanism of Parkinson’s disease are still unidentified, but excitotoxicity, oxidative stress, and neuroinflammation are...
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Cardarin Effect on the Formation of Histopathological and Behavioral Abnormalities in the Lithium-Pilocarpine Model of Temporal Lobe Epilepsy in Rats
AbstractEpilepsy is a severe neuropsychological disease accompanied by the development of spontaneous recurrent seizures (SRS) and...
