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Molecular Toxicity Mechanism of Plasticizers in the Reservoir

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Reservoir Ecotoxicology

Abstract

Plasticizers, due to their robustness, flexibility, and low production costs, have broad industrial applications. However, they are released into the reservoir environment because of inappropriate disposal discharge and cause adverse health effects. This chapter mainly focuses on the molecular mechanism of the plasticizers, particularly phthalates (PAEs) and bisphenol A (BPA), when they are exposed to or interacted with organisms. Previously, various studies have reported that plasticizers affect growth development by altering the thyroid and estrogen axis, leading to infertility. Furthermore, these chemicals can disturb reproductive capacity and decrease egg production via reducing steroidogenesis, activating peroxisome proliferator receptors (PPAR), and enhancing oxidative stress levels. In a nutshell, plasticizer pollution in the reservoir should be deeply concerned, and more studies on the adverse health effects of plasticizers on aquatic species are critically needed.

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Acknowledgments

This work was supported by the funds from the High-level Talents Project of Chongqing Medical University (No. R4014) and Research Program of Chongqing Science and Technology Commission (No. cstc2019jcyj-zdxmX0035 and CSTCCXLJRC201714).

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The authors declare no conflict of interest.

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Authors and Affiliations

  1. School of Public Health, Chongqing Medical University, Chongqing, China

    Naima Hamid & De-Sheng Pei

  2. Department of Environmental Science, Lahore College for Women University, Lahore, Pakistan

    Naima Hamid

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Correspondence to De-Sheng Pei .

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Hamid, N., Pei, DS. (2023). Molecular Toxicity Mechanism of Plasticizers in the Reservoir. In: Reservoir Ecotoxicology. Springer, Cham. https://doi.org/10.1007/978-3-031-26344-6_16

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