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Lactic Acid Production from Fungal Machineries and Mechanism of PLA Synthesis: Application of AI-Based Technology for Improved Productivity
Lactic acid production and its polymerization to poly-lactide (PLA) using renewable resources have recently gained advancement in the field of...
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Molecular basis for nuclear accumulation and targeting of the inhibitor of apoptosis BIRC2
The inhibitor of apoptosis protein BIRC2 regulates fundamental cell death and survival signaling pathways. Here we show that BIRC2 accumulates in the...
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BoaγPLI from Boa constrictor Blood is a Broad-Spectrum Inhibitor of Venom PLA2 Pathophysiological Actions
The use of venom in predation exerts a corresponding selection pressure for the evolution of venom resistance. One of the mechanisms related to venom...
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Malonyl-CoA is a conserved endogenous ATP-competitive mTORC1 inhibitor
Cell growth is regulated by the mammalian/mechanistic target of rapamycin complex 1 (mTORC1), which functions both as a nutrient sensor and a master...
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Rational optimization of a transcription factor activation domain inhibitor
Transcription factors are among the most attractive therapeutic targets but are considered largely ‘undruggable’ in part due to the intrinsically...
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iASPP suppression mediates terminal UPR and improves BRAF-inhibitor sensitivity of colon cancers
Unfolded protein response (UPR) signaling is activated under endoplasmic reticulum (ER) stress, an emerging cancer hallmark, leading to either...
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Inhibitor of nuclear factor kappa B kinase subunit epsilon regulates murine acetaminophen toxicity via RIPK1/JNK
Drug-induced liver injury (DILI) still poses a major clinical challenge and is a leading cause of acute liver failure. Inhibitor of nuclear factor...
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An allosteric inhibitor against the therapy-resistant mutant forms of EGFR in non-small cell lung cancer
Epidermal growth factor receptor (EGFR) therapy using small-molecule tyrosine kinase inhibitors (TKIs) is initially efficacious in patients with...
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The mitochondrial inhibitor IF1 binds to the ATP synthase OSCP subunit and protects cancer cells from apoptosis
The mitochondrial protein IF1 binds to the catalytic domain of the ATP synthase and inhibits ATP hydrolysis in ischemic tissues. Moreover, IF1 is...
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SIRT1 and HSP90α feed-forward circuit safeguards chromosome segregation integrity in diffuse large B cell lymphomas
Diffuse large B-cell lymphoma (DLBCL) is the most common aggressive non-Hodgkin lymphoma in adults, exhibiting highly heterogenous clinical behavior...
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In Situ Hybridization-Proximity Ligation Assay (ISH-PLA) to Study the Interaction of HIV-1 RNA and Remodeling Proteins
The mechanisms involved in the posttranscriptional control of the replicative cycle of the human immunodeficiency virus (HIV), specifically the...
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Inhibitor of DNA binding 2 (Id2) mediates microtubule polymerization in the brain by regulating αK40 acetylation of α-tubulin
Acetylation of α-tubulin lysine 40 (αK40) contributes to microtubule (MT) stability and is essential for neuronal development and function, whereas...
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Coenzyme self-sufficiency system-recent advances in microbial production of high-value chemical phenyllactic acid
Phenyllactic acid (PLA), a natural antimicrobial substance, has many potential applications in the food, animal feed, pharmaceutical and cosmetic...
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Using a Modified Proximity Ligation Protocol to Study the Interaction Between Chaperones and Associated Proteins
Molecular chaperones can interact with multiple proteins to form large networks. Understanding these interactions may shed light on the complexity of...
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Proximity Ligation Assay for Detection of R-Loop Complexes upon DNA Damage
In situ Proximity Ligation Assay (PLA Proximity Ligation Assay (PLA) ) can be used to detect the close proximity (less than ~40 nm) of two biological...
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Improvement of damaged cavernosa followed by neuron-like differentiation at injured cavernous nerve after transplantation of stem cells seeded on the PLA nanofiber in rats with cavernous nerve injury
This study investigated the differentiation of transplanted transplanted mesenchymal stem cells MSCs into neuron-like cells, repair of erectile...
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Surface protein profiling of prostate-derived extracellular vesicles by mass spectrometry and proximity assays
Extracellular vesicles (EVs) are mediators of intercellular communication and a promising class of biomarkers. Surface proteins of EVs play decisive...
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A novel RIP1/RIP3 dual inhibitor promoted OPC survival and myelination in a rat neonatal white matter injury model with hOPC graft
BackgroundThe dual inhibitors of receptor interacting protein kinase-1 and -3 (RIP1 and RIP3) play an important role in cell death processes and...
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CIP2A induces PKM2 tetramer formation and oxidative phosphorylation in non-small cell lung cancer
Tumor cells are usually considered defective in mitochondrial respiration, but human non-small cell lung cancer (NSCLC) tumor tissues are shown to...
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Quantification of Protein Expression by Proximity Ligation Assay in the Nonhuman Primate in Response to Estrogen
In the field of protein biology, immunology-based techniques are continuously evolving for the detection and quantification of individual protein...