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Human Blood Serum Counteracts EGFR/HER2-Targeted Drug Lapatinib Impact on Squamous Carcinoma SK-BR-3 Cell Growth and Gene Expression
AbstractLapatinib is a targeted therapeutic inhibiting HER2 and EGFR proteins. It is used for the therapy of HER2-positive breast cancer, although...
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Identification of key genes in oral squamous cell carcinoma by integrated bioinformatics analysis
Oral squamous cell carcinoma (OSCC) is one of the most malignant diseases in the world, and the driver genes or signaling pathways remain unclear....
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IGF2BP3 promotes the progression of colorectal cancer and mediates cetuximab resistance by stabilizing EGFR mRNA in an m6A-dependent manner
Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3), an RNA-binding protein, is associated with tumorigenesis and progression. However, the...
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Milk somatic cell derived transcriptome analysis identifies regulatory genes and pathways during lactation in Indian Sahiwal cattle (Bos indicus)
BackgroundThe present study is an effort to understand the genomic drivers of lactation in Sahiwal ( Bos indicus ), the best milch cattle breed of the...
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METTL14-dependent maturation of pri-miR-17 regulates mitochondrial homeostasis and induces chemoresistance in colorectal cancer
miR-17-5p has been found to be involved in the proliferation and metastasis of colorectal cancer (CRC), and N 6 -methyladenosine (m 6 A) modification is...
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Loss of PBX1 function in Leydig cells causes testicular dysgenesis and male sterility
Leydig cells are essential components of testicular interstitial tissue and serve as a primary source of androgen in males. A functional deficiency...
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The granulosa cell response to luteinizing hormone is partly mediated by YAP1-dependent induction of amphiregulin
BackgroundThe LH surge is a pivotal event that triggers multiple key ovarian processes including oocyte maturation, cumulus expansion, follicular...
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Structure of CRL7FBXW8 reveals coupling with CUL1–RBX1/ROC1 for multi-cullin-RING E3-catalyzed ubiquitin ligation
Most cullin-RING ubiquitin ligases (CRLs) form homologous assemblies between a neddylated cullin-RING catalytic module and a variable...
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The role of prickle proteins in vertebrate development and pathology
Prickle is an evolutionarily conserved family of proteins exclusively associated with planar cell polarity (PCP) signalling. This signalling pathway...
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Differential transcriptome analysis in HPV-positive and HPV-negative cervical cancer cells through CRISPR knockout of miR-214
In this study we have investigated the effects of a tumour suppressor microRNA, miR-214, on gene expression in HPV-positive (CaSki) and HPV-negative...
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Genome-wide association analysis for body weight identifies candidate genes related to development and metabolism in rainbow trout (Oncorhynchus mykiss)
Growth is one of the most important traits from both a physiological and economic perspective in aquaculture species. Thus, identifying the genomic...
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Phosphoproteomics identifies dual-site phosphorylation in an extended basophilic motif regulating FILIP1-mediated degradation of filamin-C
The PI3K/Akt pathway promotes skeletal muscle growth and myogenic differentiation. Although its importance in skeletal muscle biology is well...
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Actin–microtubule crosstalk in cell biology
The cytoskeleton and its components — actin, microtubules and intermediate filaments — have been studied for decades, and multiple roles of the...
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Calcineurin is an important factor involved in glucose uptake in human adipocytes
Calcineurin inhibitors are used in immunosuppressive therapy applied after transplantation, but they are associated with major metabolic side effects...
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Re-evaluation of protein kinase CK2 pleiotropy: new insights provided by a phosphoproteomics analysis of CK2 knockout cells
CK2 denotes a ubiquitous and pleiotropic protein kinase whose holoenzyme is composed of two catalytic (α and/or α′) and two regulatory β subunits....
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Exploring evidence of positive selection signatures in cattle breeds selected for different traits
Since domestication, the genome landscape of cattle has been changing due to natural and artificial selection forces resulting in several general and...
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Characterization of chromatin accessibility with a transposome hypersensitive sites sequencing (THS-seq) assay
Chromatin accessibility captures in vivo protein-chromosome binding status, and is considered an informative proxy for protein-DNA interactions....
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Multiple functional linear model for association analysis of RNA-seq with imaging
Emerging integrative analysis of genomic and anatomical imaging data which has not been well developed, provides invaluable information for the...
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CLASPs link focal-adhesion-associated microtubule capture to localized exocytosis and adhesion site turnover
Turnover of integrin-based focal adhesions (FAs) with the extracellular matrix (ECM) is essential for coordinated cell movement. In collectively...
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Integrative genomics and transcriptomics analysis of human embryonic and induced pluripotent stem cells
BackgroundHuman genomic variations, including single nucleotide polymorphisms (SNPs) and copy number variations (CNVs), are associated with several...
