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Cardiac Glycosides: Distribution, Properties and Specificity of Formation in Plant Cell and Organ Cultures In Vitro
AbstractSecondary metabolism (the formation of substances of specialized metabolism) is one of the distinctive specificities of the plant organism....
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The genetic architecture of biological age in nine human organ systems
Investigating the genetic underpinnings of human aging is essential for unraveling the etiology of and develo** actionable therapies for chronic...
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Circadian-driven tissue specificity is constrained under caloric restricted feeding conditions
Tissue specificity is a fundamental property of an organ that affects numerous biological processes, including aging and longevity, and is regulated...
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Targeting tumor suppressor p53 for organ fibrosis therapy
Fibrosis is a reparative and progressive process characterized by abnormal extracellular matrix deposition, contributing to organ dysfunction in...
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Organ-specific characteristics govern the relationship between histone code dynamics and transcriptional reprogramming during nitrogen response in tomato
Environmental stimuli trigger rapid transcriptional reprogramming of gene networks. These responses occur in the context of the local chromatin...
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Use and application of organ-on-a-chip platforms in cancer research
Tumors are a major cause of death worldwide, and much effort has been made to develop appropriate anti-tumor therapies. Existing in vitro and in vivo...
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CircRNAs: versatile players and new targets in organ fibrosis
Organ fibrosis can occur in virtually all major organs with relentlessly progressive and irreversible progress, ultimately resulting in organ...
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Moonlighting enzymes: when cellular context defines specificity
It is not often realized that the absolute protein specificity is an exception rather than a rule. Two major kinds of protein multi-specificities are...
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Olfactory Organ of Anemonefishes of the Genus Amphiprion (Amphiprioninae, Pomacentridae)
Abstract —The structure of the olfactory organ is studied in five species of anemonefishes of the genus Amphiprion : A. polymnus , A. clarkii , A....
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Organ Map** Antibody Panels: a community resource for standardized multiplexed tissue imaging
Multiplexed antibody-based imaging enables the detailed characterization of molecular and cellular organization in tissues. Advances in the field now...
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The pharyngeal taste organ of a blood-feeding insect functions in food recognition
BackgroundObligate blood-feeding insects obtain the nutrients and water necessary to ensure survival from the vertebrate blood. The internal taste...
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Mammalian organ regeneration in spiny mice
Fibrosis-driven solid organ failure is a major world-wide health burden with few therapeutic options. Spiny mice (genus: Acomys ) are terrestrial...
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Central projections from Johnston’s organ in the locust: Axogenesis and brain neuroarchitecture
Johnston’s organ (Jo) acts as an antennal wind-sensitive and/or auditory organ across a spectrum of insect species and its axons universally project...
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Dual specificity and target gene selection by the MADS-domain protein FRUITFULL
How transcription factors attain their target gene specificity and how this specificity may be modulated, acquiring different regulatory functions...
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Specificity of Growth and Accumulation of Flavonoids in Plants and Cell Cultures of Lychnis chalcedonica Obtained from Explants of Different Organs
AbstractFlavonoids have numerous functions in plants, one of which is growth regulation. During the study, callus cultures were obtained from...
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Tetralol derivative NNC-55-0396 targets hypoxic cells in the glioblastoma microenvironment: an organ-on-chip approach
Glioblastoma (GBM) is a highly malignant brain tumour characterised by limited treatment options and poor prognosis. The tumour microenvironment,...
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GOLPH3 protein controls organ growth by interacting with TOR signaling proteins in Drosophila
The oncoprotein GOLPH3 (Golgi phosphoprotein 3) is an evolutionarily conserved phosphatidylinositol 4-phosphate effector, mainly localized to the...
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Light as an elicitor for enhanced production of secondary metabolites in plant cell, tissue, and organ cultures
Currently, in vitro cell, tissue, and organ cultures are used to produce plant secondary metabolites that are used as natural coloring agents,...
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Early embryonic development of Johnston’s organ in the antenna of the desert locust Schistocerca gregaria
Johnston’s organ has been shown to act as an antennal auditory organ across a spectrum of insect species. In the hemimetabolous desert locust Schistoce...
