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Ocular complaints and diagnoses in spaceflight
The NASA human system risk board (HSRB) has long focused on trauma and acute medical illness as a key contributor to high level in-flight medical...
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Ocular conditions and injuries, detection and management in spaceflight
Ocular trauma or other ocular conditions can be significantly debilitating in space. A literature review of over 100 articles and NASA evidence...
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Assessment of Mucin-Associated Gene Expression Levels on the Ocular Surface
The ocular surface is covered with a mucus layer. The mucin-associated genes expressed in the ocular surface cells include MUC1, MUC4, MUC5AC, and...
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Potential roles of lncRNA MALAT1-miRNA interactions in ocular diseases
Long non-coding RNAs (lncRNAs) are non-protein coding transcripts that are longer than 200 nucleotides in length. LncRNAs are implicated in gene...
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Role of Oxysterols in Ocular Degeneration Mechanisms and Involvement of P2X7 Receptor
Ocular degeneration, including cataracts, glaucoma, macular degeneration, and diabetic retinopathy, is a major public health challenge, as it affects...
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Ocular A-to-I RNA editing signatures associated with SARS-CoV-2 infection
Ophthalmic manifestations have recently been observed in acute and post-acute complications of COVID-19 caused by SARS-CoV-2 infection. Our precious...
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Linking cerebral hemodynamics and ocular microgravity-induced alterations through an in silico-in vivo head-down tilt framework
Head-down tilt (HDT) has been widely proposed as a terrestrial analog of microgravity and used also to investigate the occurrence of...
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Contrast Sensitivity and Ocular Microtremor: A Model Study of Gravity Effects on Visual Perception
AbstractAn assessment was made of visual contrast sensitivity and tremor micromovements of the eyes under conditions of “dry” immersion (DI), which...
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Ocular perfusion pressure is not reduced in response to lower body negative pressure
Lower body negative pressure (LBNP) has been proposed as a countermeasure to mitigate the cephalad fluid shift occurring during spaceflight, which...
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Metagenomic analysis of microbiological changes on the ocular surface of diabetic children and adolescents with a dry eye
BackgroundMicrobiome changes on the ocular surface may cause dry eyes. A metagenome assay was used to compare the microbiome composition and function...
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Interferon-γ elicits the ocular surface pathology mimicking dry eye through direct modulation of resident corneal cells
Despite accumulating evidence indicating a key role of interferon-γ (IFN-γ)-producing immune cells in ocular infection and immunity, little is known...
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Ultrasonographic and histopathologic features associated with common ocular diseases in donkeys (Equus asinus)
There is a lack of reports describing ultrasonographic and histopathologic features of ocular diseases in donkeys. The present study aimed to...
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Ferroptosis: mechanisms and advances in ocular diseases
As an essential trace element in the body, iron is critical for the maintenance of organismal metabolism. Excessive iron facilitates reactive oxygen...
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Potential in exosome-based targeted nano-drugs and delivery vehicles for posterior ocular disease treatment: from barriers to therapeutic application
Posterior ocular disease, a disease that accounts for 55% of all ocular diseases, can contribute to permanent vision loss if left without treatment....
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Autophagy deficiency protects against ocular hypertension and neurodegeneration in experimental and spontaneous glaucoma mouse models
Glaucoma is a group of diseases that leads to chronic degeneration of retinal ganglion cell (RGC) axons and progressive loss of RGCs, resulting in...
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Significantly different results in the ocular surface microbiome detected by tear paper and conjunctival swab
BackgroundGreat variation has been observed in the composition of the normal microbiota of the ocular surface, and therefore, in addition to...
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Unique composition of ocular surface microbiome in the old patients with dry eye and diabetes mellitus in a community from Shanghai, China
BackgroundThis study investigates the variations in microbiome abundance and diversity on the ocular surfaces of diabetic patients suffering from dry...
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The role of long noncoding RNAs in ocular angiogenesis and vascular oculopathy
BackgroundLong noncoding RNAs (lncRNAs) are RNA transcripts over 200 nucleotides in length that do not code for proteins. Initially considered a...
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Dynamic changes in perivascular space morphology predict signs of spaceflight-associated neuro-ocular syndrome in bed rest
During long-duration spaceflight, astronauts experience headward fluid shifts and expansion of the cerebral perivascular spaces (PVS). A major...
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Change in Eye Hydrodynamics as a Pathogenesis Factor of Space-Flight Associated Neuro-Ocular Syndrome (SANS)
AbstractStudies of the mechanisms of visual analyzer adaptation in remote space missions are of paramount importance in the domain of space medicine....
