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Identification of a longevity gene through evolutionary rate covariation of insect mito-nuclear genomes
Oxidative phosphorylation, essential for energy metabolism and linked to the regulation of longevity, involves mitochondrial and nuclear genes. The...
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A Fluorescence-Based Reporter Gene Assay to Characterize Nuclear Receptor Modulators
Reporter gene assays are critical tools of nuclear receptorNuclear receptor (NR) research for characterizing the effects of ligands on nuclear...
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Evaluating the role of the nuclear microenvironment in gene function by population-based modeling
The nuclear folding of chromosomes relative to nuclear bodies is an integral part of gene function. Here, we demonstrate that population-based...
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Nuclear ATP-citrate lyase regulates chromatin-dependent activation and maintenance of the myofibroblast gene program
Differentiation of cardiac fibroblasts to myofibroblasts is necessary for matrix remodeling and fibrosis in heart failure. We previously reported...
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Rhes, a striatal enriched protein, regulates post-translational small-ubiquitin-like-modifier (SUMO) modification of nuclear proteins and alters gene expression
Rhes (Ras homolog enriched in the striatum), a multifunctional protein that regulates striatal functions associated with motor behaviors and...
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Proxiome assembly of the plant nuclear pore reveals an essential hub for gene expression regulation
The nuclear pore complex (NPC) is vital for nucleocytoplasmic communication. Recent evidence emphasizes its extensive association with proteins of...
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Two target gene activation pathways for orphan ERR nuclear receptors
Estrogen-related receptors (ERRα/β/γ) are orphan nuclear receptors that function in energy-demanding physiological processes, as well as in...
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Nuclear receptor gene expression during early gametogenesis in sea urchin Mesocentrotus nudus gonads
Gametogenesis and the accumulation of nutrients such as proteins progress in sea urchin gonads during their growth. In vertebrate species, these...
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Integration of nuclear Ca2+ transients and subnuclear protein shuttling provides a novel mechanism for the regulation of CREB-dependent gene expression
Nuclear Ca 2+ waves elicited by NMDAR and L-type voltage-gated Ca 2+ -channels as well as protein transport from synapse-to-nucleus are both...
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Phylogeny of the Dipus sagitta Species Complex by Nuclear Gene Sequences
The northern three-toed jerboa Dipus sagitta had long been considered to be a single polytypic species. High genetic diversity of D. sagitta was...
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Phylogenetic analysis and stress response of the plant U2 small nuclear ribonucleoprotein B″ gene family
BackgroundAlternative splicing (AS) is an important channel for gene expression regulation and protein diversification, in addition to a major reason...
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Nuclear Actin Dynamics in Gene Expression, DNA Repair, and Cancer
Actin is a highly conserved protein in mammals. The actin dynamics is regulated by actin-binding proteins and actin-related proteins. Nuclear actin...
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Nuclear receptor Nr1d1 alleviates asthma by abating GATA3 gene expression and Th2 cell differentiation
Nuclear receptors are a unique family of transcription factors that play cardinal roles in physiology and plethora of human diseases. The adopted...
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Nuclear Pore Complex-Regulated Transcription and Memory
The nuclear pore complex (NPC) stands as a marvel of cellular architecture that orchestrates the bidirectional traffic of macromolecules between the...
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Exogenous interleukin-1 beta stimulation regulates equine tenocyte function and gene expression in three-dimensional culture which can be rescued by pharmacological inhibition of interleukin 1 receptor, but not nuclear factor kappa B, signaling
We investigated how Interleukin 1 beta (IL-1β) impacts equine tenocyte function and global gene expression in vitro and determined if these effects...
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Mitotic bookmarking redundancy by nuclear receptors in pluripotent cells
Mitotic bookmarking transcription factors (TFs) are thought to mediate rapid and accurate reactivation after mitotic gene silencing. However, the...
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NEAT-seq: simultaneous profiling of intra-nuclear proteins, chromatin accessibility and gene expression in single cells
In this work, we describe NEAT-seq (sequencing of nuclear protein epitope abundance, chromatin accessibility and the transcriptome in single cells),...
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The inner nuclear membrane protein Lem2 coordinates RNA degradation at the nuclear periphery
Transcriptionally silent chromatin often localizes to the nuclear periphery. However, whether the nuclear envelope (NE) is a site for...
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Nuclear Transcription Factor Detection
Cellular fate is determined by the activity of nuclear transcription factors. Here, we describe a series of protocols for detecting transcription...