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Cell-Materials Interaction
Cells are able to respond to different physicochemical stimuli due to a complex molecular system that governs that response. The cell response to...
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Novel interaction between neurotrophic factor-α1/carboxypeptidase E and serotonin receptor, 5-HTR1E, protects human neurons against oxidative/neuroexcitotoxic stress via β-arrestin/ERK signaling
Protecting neurons from death during oxidative and neuroexcitotoxic stress is key for preventing cognitive dysfunction. We uncovered a novel...
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Exploration of interaction interface of TRKβ/BDNF through fingerprint analysis to disinter potential agonists
Tyrosine Kinase beta (TRKβ), is a type I membrane receptor which plays a major role in various signalling pathways. TRKβ was found to be upregulated...
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Products of Selenite/Thiols Interaction Have Reducing Properties, Cleave Plasmid DNA and Decrease Rat Blood Pressure and Tension of Rat Mesenteric Artery
Selenium compounds exert their antioxidant activity mostly when the selenium atom is incorporated into selenoproteins. In our work, we tested the...
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Effect of Nitric Oxide Synthase Inhibitors on Serotonin Release in Medial Prefrontal Cortex during Conditioned Fear Response Acquisition and Generalization in Rats
AbstractSerotonergic and nitrergic systems in the medial prefrontal cortex (mPFC) are involved in the control of fear generalization, but their local...
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Interaction of Melatonin with Reactive Oxygen Species in Plants
Climate change has resulted in a steady and irreversible shift in the global climate, and occurrences like salinity, drought, temperature rises, high...
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Structure- and Cation-Dependent Mechanism of Interaction of Tricyclic Antidepressants with NMDA Receptor According to Molecular Modeling Data
AbstractSome tricyclic antidepressants (TCAs), including amitriptyline (ATL), clomipramine (CLO), and desipramine (DES), are known to be effective...
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Spatial Organization of the Components of the Serotonergic System in the Early Mouse Development
Abstract —Serotonin is a regulator of early embryonic development and has a complete functional system in preimplantation mammalian embryos. In the...
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Reactive Nitrogen Species (RNS) and Melatonin Interaction in Plant
It is a well-known fact that plant productivity is greatly affected when multiple stresses are present together, as evidenced by the 30% reduction in...
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The Effect of Neurotransmitters on Programmed Cell Death and Formation of Reactive Oxygen Species in the Pea Leaf Epidermis
AbstractNeurotransmitters are found not only in animals, but also in other living organisms, including plants. However, the data on the functions of...
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Interaction Between Melatonin and Other Signaling Molecules in Plants
Numerous studies have proven evidence that melatonin plays an important regulatory role in plant growth, development, and defense against various...
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The serotonin transporter sustains human brown adipose tissue thermogenesis
Activation of brown adipose tissue (BAT) in humans is a strategy to treat obesity and metabolic disease. Here we show that the serotonin transporter...
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Interaction effects of the 5-HTT and MAOA-uVNTR gene variants on pre-attentive EEG activity in response to threatening voices
Both the serotonin transporter polymorphism ( 5-HTTLPR ) and the monoamine oxidase A gene ( MAOA-uVNTR ) are considered genetic contributors for...
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Regulation of serotonin production by specific microbes from piglet gut
BackgroundSerotonin is an important signaling molecule that regulates secretory and sensory functions in the gut. Gut microbiota has been...
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Effect of Activation and Blockade of Nitrergic Neurotransmission on Serotonin System Activity of the Rat Medial Prefrontal Cortex
AbstractNitric oxide (NO) and serotonin play an important role in the functioning of the medial prefrontal cortex, but their interaction has been...
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Melissa officinalis Interaction with Opioid Receptors Attenuates Stress-Induced Anxiety-Like and OCD-Like Behaviors
AbstractMelissa officinalis (MO) is a valuable medicinal herb from the Lamiaceae family, MO extracts possess different beneficial effects, including...
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Modular tissue-in-a-CUBE platform to model blood-brain barrier (BBB) and brain interaction
With the advent of increasingly sophisticated organoids, there is growing demand for technology to replicate the interactions between multiple...
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Glycosylated SARs Cov 2 interaction with plant lectins
Lectins are non-immune carbohydrate-binding proteins/glycoproteins that are found everywhere in nature, from bacteria to human cells. They have also...
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Learning self-supervised molecular representations for drug–drug interaction prediction
Drug–drug interactions (DDI) are a critical concern in healthcare due to their potential to cause adverse effects and compromise patient safety....
