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Characteristics of nuclear architectural abnormalities of myotubes differentiated from LmnaH222P/H222P skeletal muscle cells
The presence of nuclear architectural abnormalities is a hallmark of the nuclear envelopathies, which are a group of diseases caused by mutations in...
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Exclusive vital labeling of myonuclei for studying myonuclear arrangement in mouse skeletal muscle tissue
BackgroundThe arrangement of myonuclei in skeletal muscle tissue has long been used as a biomarker for muscle health, but there is a dearth of in...
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Neither myonuclear accretion nor a myonuclear domain size ceiling is a feature of the attenuated hypertrophic potential of aged human skeletal muscle
Ageing limits growth capacity of skeletal muscle (e.g. in response to resistance exercise), but the role of satellite cell (SC) function in driving...
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Programmed Cell Death and its Implications for Skeletal Muscle Wasting
Skeletal muscle atrophy is an inevitable sequel of various factors such as cachexia, aging, fasting, denervation, and microgravity. It is...
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NG2-positive pericytes regulate homeostatic maintenance of slow-type skeletal muscle with rapid myonuclear turnover
BackgroundSkeletal muscle comprises almost 40% of the human body and is essential for movement, structural support and metabolic homeostasis. Size of...
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MuscleJ2: a rebuilding of MuscleJ with new features for high-content analysis of skeletal muscle immunofluorescence slides
Histological analysis of skeletal muscle is of major interest for understanding its behavior in different pathophysiological conditions, such as the...
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Differences in muscle satellite cell dynamics during muscle hypertrophy and regeneration
Skeletal muscle homeostasis and function are ensured by orchestrated cellular interactions among several types of cells. A noticeable aspect of...
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Eliminating elevated p53 signaling fails to rescue skeletal muscle defects or extend survival in lamin A/C-deficient mice
Lamins A and C, encoded by the LMNA gene, are nuclear intermediate filaments that provide structural support to the nucleus and contribute to...
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Single nuclei transcriptomics of muscle reveals intra-muscular cell dynamics linked to dystrophin loss and rescue
In Duchenne muscular dystrophy, dystrophin loss leads to chronic muscle damage, dysregulation of repair, fibro-fatty replacement, and weakness. We...
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Motoneurons innervation determines the distinct gene expressions in multinucleated myofibers
BackgroundNeuromuscular junctions (NMJs) are peripheral synapses connecting motoneurons and skeletal myofibers. At the postsynaptic side in...
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Clinical Trials of Cell Therapy and Regenerative Medicine in Muscular Dystrophies
Cell therapy could form part of the future treatment of degenerative disorders of genetic origin that affect skeletal muscles, such as muscular...
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Cell type map** of inflammatory muscle diseases highlights selective myofiber vulnerability in inclusion body myositis
Inclusion body myositis (IBM) is the most prevalent inflammatory muscle disease in older adults with no effective therapy available. In contrast to...
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Clinical Trials of Cell Therapy and Regenerative Medicine in Muscular Dystrophies
Cell therapy could form part of the future treatment of degenerative disorders of genetic origin that affect skeletal muscles, such as muscular...
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Exercise promotes satellite cell contribution to myofibers in a load-dependent manner
BackgroundSatellite cells (SCs) are required for muscle repair following injury and are involved in muscle remodeling upon muscular contractions....
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The Myotube Analyzer: how to assess myogenic features in muscle stem cells
BackgroundThe analysis of in vitro cultures of human adult muscle stem cells obtained from biopsies delineates the potential of skeletal muscles and...
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Decoding the transcriptome of Duchenne muscular dystrophy to the single nuclei level reveals clinical-genetic correlations
Duchenne muscular dystrophy is a genetic disease produced by mutations in the dystrophin gene characterized by early onset muscle weakness leading to...
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Human skeletal muscle aging atlas
Skeletal muscle aging is a key contributor to age-related frailty and sarcopenia with substantial implications for global health. Here we profiled...
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Impacts of radiation exposure, hindlimb unloading, and recovery on murine skeletal muscle cell telomere length
Astronauts are exposed to harsh conditions, including cosmic radiation and microgravity. Spaceflight elongates human telomeres in peripheral blood,...
