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Alteration of gene expression profiles in the mutant line of Sorghum bicolor
The induction of mutants using a variety of mutagens provides new genetic resources for crop breeding. In the current study, we generated mutants in...
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Establishment and characterization of BMC-PDC-019: a novel patient-derived cell line of EGFR-mutant pulmonary adenocarcinoma transformed into small-cell lung cancer
Transformed small-cell lung cancer (tSCLC) from EGFR-mutant adenocarcinoma is a rare and aggressive form of lung cancer that can occur when the tumor...
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Spike (S) Glycoprotein D614G Mutant
Recently, the SARS-CoV-2 D614G mutant has been reported to be potentially more transmissible (“contagious”) than its wild-type. When there is no...
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Molecular Markers for Mutant Characterization
Mutants are either obtained spontaneously or artificially induced frequently in various organisms to serve several purposes like expanding the...
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Morpho-physiological and genetic characteristics of a salt-tolerant mutant line in soybean (Glycine max L.)
Key messageOne major quantitative trait loci and candidate gene for salt tolerance were identified on chromosome 3 from a new soybean mutant derived...
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Spike (S) Glycoprotein N165A and N234A Mutant
Casalino et al. (ACS Cent Sci 6:1722-1734, 2020) revealed an essential structural role of N-glycansN-glycans at sites N165 and N234 in modulating the...
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Contemplation of protein–protein interactions for salt tolerance in rice mutant lines
Proteome analyses of two contrasting mutant lines and their parent revealed responsive proteins in salt stress. The tandem mass spectrometry analysis...
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Computational Random Mutagenesis to Investigate RAS Mutant Signaling
This chapter describes how mathematical models can be used to investigate the possible range of behaviors for mutant forms of a protein. A...
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Characterization and fine map** of a white stripe leaf mutant in rice
Leaf color affects the efficiency of photosynthesis, and leaf color mutants are important genetic materials for studying the mechanisms of...
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Identification and map-based cloning of long glume mutant gene lgm1 in barley
The spikes of gramineous plants are composed of specialized units called spikelets. Two bracts at the spikelet bases are known as glumes. The...
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Development of Cowpea (Vigna unguiculata) Mutant Lines for Dissecting Resilience to Drought Through Physiological and Molecular Crosstalk Analysis
Cowpea ( Vigna unguiculata ) is a legume crop widely grown in tropical and subtropical regions for human consumption and animal feeding. Despite this...
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A pan-KRAS degrader for the treatment of KRAS-mutant cancers
KRAS mutations are highly prevalent in a wide range of lethal cancers, and these mutant forms of KRAS play a crucial role in driving cancer...
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Map** the gene of a maize leaf senescence mutant and understanding the senescence pathways by expression analysis
Key messagesNarrowing down to a single putative target gene behind a leaf senescence mutant and constructing the regulation network by proteomic...
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INPP5A phosphatase is a synthetic lethal target in GNAQ and GNA11-mutant melanomas
Activating mutations in GNAQ/GNA11 occur in over 90% of uveal melanomas (UMs), the most lethal melanoma subtype; however, targeting these oncogenes...
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STAG2 inactivation reprograms glutamine metabolism of BRAF-mutant thyroid cancer cells
STAG2, an important subunit in cohesion complex, is involved in the segregation of chromosomes during the late mitosis and the formation of sister...
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Profile-based proteomic investigation of unintended effects on transgenic and gamma radiation induced mutant soybean plants
GM risk assessments are crucial for determination and prevention of potential adverse effects through early detection and proper evaluation of...
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Distinct functions of wild-type and R273H mutant Δ133p53α differentially regulate glioblastoma aggressiveness and therapy-induced senescence
Despite being mutated in 92% of TP53 mutant cancers, how mutations on p53 isoforms affect their activities remain largely unknown. Therefore,...
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Autophagy in BRAF-mutant cutaneous melanoma: recent advances and therapeutic perspective
Macroautophagy, hereafter referred to as autophagy, represents a highly conserved catabolic process that maintains cellular homeostasis. At present,...
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KRAS-mutant non-small cell lung cancer (NSCLC) therapy based on tepotinib and omeprazole combination
BackgroundKRAS- mutant non-small cell lung cancer (NSCLC) shows a relatively low response rate to chemotherapy, immunotherapy and KRAS -G12C selective...
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Targeting NG2 relieves the resistance of BRAF-mutant thyroid cancer cells to BRAF inhibitors
BRAF V600E represents a constitutively active onco-kinase and stands as the most prevalent genetic alteration in thyroid cancer. However, the clinical...
