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Functional deterioration of vascular mitochondrial and glycolytic capacity in the aortic rings of aged mice
Vascular ageing is associated with increased arterial stiffness and cardiovascular mortality that might be linked to altered vascular energy...
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Loss of functional peroxisomes leads to increased mitochondrial biogenesis and reduced autophagy that preserve mitochondrial function
Peroxisomes are essential for mitochondrial health, as the absence of peroxisomes leads to altered mitochondria. However, it is unclear whether the...
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Intrinsic aerobic capacity modulates Alzheimer’s disease pathological hallmarks, brain mitochondrial function and proteome during aging
Low aerobic capacity is strongly associated with all-cause mortality and risk for Alzheimer’s disease (AD). Individuals with early dementia and AD...
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Small extracellular vesicles from young plasma reverse age-related functional declines by improving mitochondrial energy metabolism
Recent investigations into heterochronic parabiosis have unveiled robust rejuvenating effects of young blood on aged tissues. However, the specific...
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Lophiosilurus alexandri Functional Studies Related to Mitochondrial Bioenergetics
Lophiosilurus alexandri (pacamã) is a native fish of the São Francisco River in Brazil. Importantly, its liver bioenergetic metabolism has never been...
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Highly-purified rapidly expanding clones, RECs, are superior for functional-mitochondrial transfer
BackgroundMitochondrial dysfunction caused by mutations in mitochondrial DNA (mtDNA) or nuclear DNA, which codes for mitochondrial components, are...
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Skeletal muscle mitochondrial interactome remodeling is linked to functional decline in aged female mice
Genomic, transcriptomic and proteomic approaches have been used to gain insight into molecular underpinnings of aging in laboratory animals and in...
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Systems Biology Approach in Understanding Mitochondrial Disease
The term “mitochondrial diseases” refers to a broad category of hereditary disorders characterized by failure in the mitochondria, the cell’s...
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Genetic perturbation of mitochondrial function reveals functional role for specific mitonuclear genes, metabolites, and pathways that regulate lifespan
Altered mitochondrial function is tightly linked to lifespan regulation, but underlying mechanisms remain unclear. Here, we report the chronological...
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Functional implications of NHR-210 enrichment in C. elegans cephalic sheath glia: insights into metabolic and mitochondrial disruptions in Parkinson's disease models
Glial cells constitute nearly half of the mammalian nervous system's cellular composition. The glia in C. elegans perform majority of tasks...
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Obesity-driven mitochondrial dysfunction in human adipose tissue-derived mesenchymal stem/stromal cells involves epigenetic changes
Obesity exacerbates tissue degeneration and compromises the integrity and reparative potential of mesenchymal stem/stromal cells (MSCs), but the...
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LIN28A enhances regenerative capacity of human somatic tissue stem cells via metabolic and mitochondrial reprogramming
Develo** methods to improve the regenerative capacity of somatic stem cells (SSCs) is a major challenge in regenerative medicine. Here, we propose...
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Mir-204-5p alleviates mitochondrial dysfunction by targeting IGFBP5 in diabetic cataract
BackgroundCataract contributes to visual impairment worldwide, and diabetes mellitus accelerates the formation and progression of cataract. Here we...
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Tissue heterogeneity of mitochondrial activity, biogenesis and mitochondrial protein gene expression in buffalo
BackgroundCellular metabolism is most invariant process, occurring in all living organisms, which involves mitochondrial proteins from both nuclear...
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A small protein coded within the mitochondrial canonical gene nd4 regulates mitochondrial bioenergetics
BackgroundMitochondria have a central role in cellular functions, aging, and in certain diseases. They possess their own genome, a vestige of their...
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Mitochondrial Inheritance Following Nuclear Transfer: From Cloned Animals to Patients with Mitochondrial Disease
Mitochondria are indispensable power plants of eukaryotic cells that also act as a major biochemical hub. As such, mitochondrial dysfunction, which...
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Optimization of differential filtration-based mitochondrial isolation for mitochondrial transplant to cerebral organoids
BackgroundMitochondrial dysfunction is involved in several diseases ranging from genetic mitochondrial disorders to chronic metabolic diseases. An...
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Assaying Mitochondrial Function by Multiparametric Flow Cytometry
Flow cytometry has been a vital tool in cell biology for decades based on its versatile ability to detect and quantifiably measure both physical and...
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Relationship between skeletal mitochondrial function and digital markers of free-living physical activity in older adults
This study examined the association between in vivo skeletal mitochondrial function and digital free-living physical activity patterns—a measure that...
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Mitochondrial oxidative phosphorylation became functional under aglycemic hypoxia conditions in A549 cells
BackgroundNormal cells produce energy (ATP) through mitochondrial oxidative phosphorylation in the presence of oxygen. However, many of the cancer...
