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Graph-Based Motif Discovery in Mimotope Profiles of Serum Antibody Repertoire
Phage display technique has a multitude of applications such as epitope map**, organ targeting, therapeutic antibody engineering and vaccine...
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Evaluation of a mimotope of the Rickettsia outer membrane protein A (OmpA) as an antigen in enzyme-linked immunosorbent assay to detect rickettsiosis in capybaras (Hydrochoerus hydrochaeris), horses (Equus caballus), and opossums (Didelphis sp.)
Rickettsia rickettsii is the etiological agent of Rocky Mountain spotted fever, which is an important tick-borne zoonosis and, in Brazil, it causes...
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Lp(a), oxidized phospholipids and oxidation-specific epitopes are increased in subjects with keloid formation
BackgroundKeloid formation following trauma or surgery is common among darkly pigmented individuals. Since lipoprotein(a) [Lp(a)] has been postulated...
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Rational Identification of Conformational and Linear EGFR Epitopes Recognized Specifically by, Respectively, Type-I and Type-II Anti-EGFR Antibodies and Molecular Design of Linear Epitope-Derived Peptidic Mimotopes to Elicit Type-II Antibody
Human epidermal growth factor receptor (EGFR) has been established as a promising therapeutic target of diverse tumors and many antibody drugs have...
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Human circulating CD24hi marginal zone B cells produce IgM targeting atherogenic antigens and confer protection from vascular disease
IgMs that inactivate oxidation-specific epitopes (IgM OSE ), which are secondary products of lipid peroxidization, protect against inflammatory...
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Antibody response to oral biofilm is a biomarker for acute coronary syndrome in periodontal disease
Cumulative evidence over the last decades have supported the role of gum infections as a risk for future major cardiovascular events. The precise...
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Monkeying around with venom: an increased resistance to α-neurotoxins supports an evolutionary arms race between Afro-Asian primates and sympatric cobras
BackgroundSnakes and primates have a multi-layered coevolutionary history as predators, prey, and competitors with each other. Previous work has...
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Current Trends of Electrochemical Sensing for Mycotoxins
The presence of mycotoxins in food materials is difficult to control, and some mycotoxins are carcinogenic even at very low concentration. Therefore,...
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EGFR Mimotope Reduces the Expression of LYVE-1 in the Intestine from the M3R Immunized Mice
Primary Sjögren’s syndrome (pSS) is a prototypic autoimmune disease characterized by immune injury to the salivary and lacrimal glands with other...
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Monoclonal antibody targeting a novel linear epitope on nucleoprotein confers pan-reactivity to influenza A virus
AbstractNucleoprotein (NP) functions crucially in the replicative cycle of influenza A virus (IAV) via forming the ribonucleoprotein complex together...
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Next-Generation Phage Display to Identify Peptide Ligands of Deubiquitinases
Phage display (PD) is a powerful method and has been extensively used to generate monoclonal antibodies and identify epitopes, mimotopes, and protein...
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Conformational epitope matching and prediction based on protein surface spiral features
BackgroundA conformational epitope (CE) is composed of neighboring amino acid residues located on an antigenic protein surface structure. CEs bind...
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Phage nanoparticle as a carrier for controlling fungal infection
AbstractA mass of nanocarriers have been exploited and utilized for prevention of fungi, including organic nanomaterials, inorganic nanoparticles,...
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Yeast Display for the Identification of Peptide-MHC Ligands of Immune Receptors
T cells detect peptide antigens presented by major histocompatibility complex (MHC) proteins via their T cell receptor (TCR). The sequence diversity...
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Identification of cancer-specific motifs in mimotope profiles of serum antibody repertoire
BackgroundFor fighting cancer, earlier detection is crucial. Circulating auto-antibodies produced by the patient’s own immune system after exposure...
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Recent advances in immunoassays and biosensors for mycotoxins detection in feedstuffs and foods
Mycotoxins are secondary metabolites produced by fungus. Many mycotoxin species are highly toxic and are frequently found in cereals and feedstuffs....
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T cells targeted to TdT kill leukemic lymphoblasts while sparing normal lymphocytes
Unlike chimeric antigen receptors, T-cell receptors (TCRs) can recognize intracellular targets presented on human leukocyte antigen (HLA) molecules....
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Chimeric Antigen Receptor (CAR)-Based Cell Therapy for Type 1 Diabetes Mellitus (T1DM); Current Progress and Future Approaches
Type 1 diabetes mellitus (T1DM) is an autoimmune disease that destroys insulin-producing pancreatic β-cells. Insulin replacement therapy is currently...
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Mechanistic Insights into Immune-Microbiota Interactions and Preventive Role of Probiotics Against Autoimmune Diabetes Mellitus
Recent studies on genetically susceptible individuals and animal models revealed the potential role of the intestinal microbiota in the pathogenesis...
