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Silencing of ultradian rhythms and metabolic depression during spontaneous daily torpor in Djungarian hamsters
Ultradian rhythms of metabolism, body temperature and activity are attenuated or disappear completely during torpor in Djungarian hamsters, for all...
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A thermodynamic-based approach to model the entry into metabolic depression by mammals and birds
For decades, there was an intense debate in relation to the mechanism behind the entry into metabolic depression (EMD) of mammals and birds. The...
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Variation in metabolic rate during low tide aerial exposure in the Asian shore crab Hemigrapsus sanguineus
Intertidal animals deal with physical gradients daily that create stressful conditions across the shore. These physical gradients influence the...
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Prevention, Diagnosis, and Understanding Mechanisms of Metabolic Diseases Using Systems Biology
Human metabolic diseases are typically network diseases. These diseases including cardiovascular diseases (CVDs), type 2 diabetes (T2D), obesity,...
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Metabolic Changes and Immunity Suppression Parameters as Biomarkers of Environmental Pollutants
Pollution occurring in our surroundings is one of the most consequential challenges to health in the modern world. Any foreign material that occupies...
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Converged avenues: depression and Alzheimer’s disease– shared pathophysiology and novel therapeutics
Depression, a highly prevalent disorder affecting over 280 million people worldwide, is comorbid with many neurological disorders, particularly...
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Exercise and Nutrition: Metabolic Partners in Epigenetic Regulation
Metabolism fuels epigenetic processes, which, in turn, regulate metabolism by translating environmental stimuli into adaptations. Metabolic networks...
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The antidepressive mechanism of Longya Lilium combined with Fluoxetine in mice with depression-like behaviors
Traditional Chinese medicine is one of the most commonly used complementary and alternative medicine therapies for depression. Integrated...
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Association of indoleamine 2,3 dioxygenase, brain derived neurotrophic factor and cellular senescence in type 2 diabetes mellitus with depression: a clinical approach
Background and aimType 2 diabetes mellitus (T2DM) and depression are often linked. Several studies have reported the role of molecular markers either...
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Metabolic Messengers: ketone bodies
Prospective molecular targets and therapeutic applications for ketone body metabolism have increased exponentially in the past decade. Initially...
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Association between depression and infertility risk among American women aged 18–45 years: the mediating effect of the NHHR
Background/ObjectiveDepression and infertility are major medical and social problems. The non-high-density lipoprotein cholesterol to high-density...
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Multi-omics analysis of fecal microbiota transplantation’s impact on functional constipation and comorbid depression and anxiety
BackgroundDepression and anxiety are common comorbid diseases of constipation. Fecal microbiota transplantation (FMT) significantly relieves...
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Bacillus licheniformis prevents and reduces anxiety-like and depression-like behaviours
AbstractAs common mental disorders, depression and anxiety impact people all around the world. Recent studies have found that the gut microbiome...
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Leveraging metabolic modeling to identify functional metabolic alterations associated with COVID-19 disease severity
ObjectiveSince the COVID-19 pandemic began in early 2020, SARS-CoV2 has claimed more than six million lives world-wide, with over 510 million cases...
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Prenatal ethanol exposure and changes in fetal neuroendocrine metabolic programming
Prenatal ethanol exposure (PEE) (mainly through maternal alcohol consumption) has become widespread. However, studies suggest that it can cause...
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Herbal Medicine for the Management of Anxiety, Depression, and Insomnia
The world has advanced in technology, health care, financial instruments and management, and other aspects of human endeavors. This advancement has...
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Modulating cyclic nucleotides pathways by bioactive compounds in combatting anxiety and depression disorders
Anxiety and depression disorders are highly prevalent neurological disorders (NDs) that impact up to one in three individuals during their lifetime....
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Bile acid signaling in the regulation of whole body metabolic and immunological homeostasis
Bile acids (BAs) play a crucial role in nutrient absorption and act as key regulators of lipid and glucose metabolism and immune homeostasis. Through...
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Inhibition of astroglial hemichannels prevents synaptic transmission decline during spreading depression
BackgroundSpreading depression (SD) is an intriguing phenomenon characterized by massive slow brain depolarizations that affect neurons and glial...
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Mechanism of post-tetanic depression of slow muscle fibres
A brief tetanic stimulation has a very different effect on the subsequent isometric twitch force of fast and slow skeletal muscles. Fast muscle...