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B cell memory: from generation to reactivation: a multipronged defense wall against pathogens
Development of B cell memory is a conundrum that scientists are still exploring. Studies have been conducted in vitro and using advanced animal...
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B cell-reactive triad of B cells, follicular helper and regulatory T cells at homeostasis
Autoreactive B cells are silenced through receptor editing, clonal deletion and anergy induction. Additional autoreactive B cells are ignorant...
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Recreation of an antigen-driven germinal center in vitro by providing B cells with phagocytic antigen
Successful vaccines rely on activating a functional humoral immune response through the generation of class-switched high affinity immunoglobulins...
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Death of tonsillar B cells by NETosis
Regulating B cell death is essential for generating antibodies and maintaining immune tolerance. B cells can die by apoptosis, and we report that...
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Clonally expanded memory CD8+ T cells accumulate in atherosclerotic plaques and are pro-atherogenic in aged mice
Aging is a strong risk factor for atherosclerosis and induces accumulation of memory CD8 + T cells in mice and humans. Biological changes that occur...
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Activated-memory T cells influence naïve T cell fate: a noncytotoxic function of human CD8 T cells
T cells are endowed with the capacity to sense their environment including other T cells around them. They do so to set their numbers and activation...
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BNT162b2-induced memory T cells respond to the Omicron variant with preserved polyfunctionality
The Omicron variant (B.1.1.529) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) extensively escapes neutralizing antibodies elicited...
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Combined FRET-FLIM and NAD(P)H FLIM to Analyze B Cell Receptor Signaling Induced Metabolic Activity of Germinal Center B Cells In Vivo
Affinity maturation of B cell clones within germinal centers constitutes an important mechanism for immune memory. During this process, B cell...
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Tyrosine kinase 2 modulates splenic B cells through type I IFN and TLR7 signaling
Tyrosine kinase 2 (TYK2) is involved in type I interferon (IFN-I) signaling through IFN receptor 1 (IFNAR1). This signaling pathway is crucial in the...
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Production and use of antigen tetramers to study antigen-specific B cells
B cells generate antibodies that provide protection from infection, but also cause pathology in autoimmune and allergic conditions. Antigen-specific...
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Cancer cells resistant to immune checkpoint blockade acquire interferon-associated epigenetic memory to sustain T cell dysfunction
Prolonged interferon (IFN) signaling in cancer cells can promote resistance to immune checkpoint blockade (ICB). How cancer cells retain effects of...
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EphB2 activation in neural stem cells in the basolateral amygdala facilitates neurogenesis and enhances long-term memory
Many brain diseases lead to a reduction in the number of functional neurons and it would be of value to be able to increase the number of neurons in...
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The superantigens SpeC and TSST-1 specifically activate TRBV12-3/12-4+ memory T cells
Severe bacterial or viral infections can induce a state of immune hyperactivation that can culminate in a potentially lethal cytokine storm. The...
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Frequency of B-Cell Subpopulations in Low Responders in Comparison with High Responders to Hepatitis B Vaccine Among Health Care Workers
Vaccination is the most effective way to prevent Hepatitis B (HB) infection. The goal of vaccination is to induce immunological memory. Hence,...
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Multiple sclerosis patient-derived spontaneous B cells have distinct EBV and host gene expression profiles in active disease
Epstein–Barr virus (EBV) is an aetiologic risk factor for the development of multiple sclerosis (MS). However, the role of EBV-infected B cells in...
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scBCR-seq revealed a special and novel IG H&L V(D)J allelic inclusion rearrangement and the high proportion dual BCR expressing B cells
Since the initial report of V (D) J “allelic exclusion/inclusion” (allelic exclusion rearrangement or allelic inclusion rearrangement) and the...
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Epstein Barr virus-mediated transformation of B cells from XIAP-deficient patients leads to increased expression of the tumor suppressor CADM1
X-linked lymphoproliferative disease (XLP) is either caused by loss of the SLAM-associated protein (SAP; XLP-1) or the X-linked inhibitor of...
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An intercellular transfer of telomeres rescues T cells from senescence and promotes long-term immunological memory
The common view is that T lymphocytes activate telomerase to delay senescence. Here we show that some T cells (primarily naïve and central memory...
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Quantification of Intracellular ATP Content in Ex Vivo GC B Cells
The study of immunometabolism is an important and emerging field in immunology. B-cell activation upon antigen recognition induces profound metabolic...
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Role of the Hematopoietic Stem Cells in Immunological Memory
Purpose of ReviewImmunological memory is an important evolutionary adaptation of the immune system. Previously restricted to the adaptive immune...