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Combined Analysis of the Metabolome and Transcriptome Sheds New Light on the Mechanisms of Seed Maturation in Amorphophallus muelleri
Amorphophallus muelleri, a naturally occurring variant of the commercially valuable Amorphophallus species grown in Southeast Asia, stands out for...
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Single-cell multi-omics profiling reveals key regulatory mechanisms that poise germinal vesicle oocytes for maturation in pigs
The molecular mechanisms controlling the transition from meiotic arrest to meiotic resumption in mammalian oocytes have not been fully elucidated....
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Maturation
Spirits stored in wooden casks “mature” over time: in addition to color change, certain negative characteristics diminish, and new beneficial...
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Seed Development and Maturation
In plants, a fascinating set of post-fertilization events result in the development of a dispersal unit known as a seed. During the maturation phase,...
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Molecular mechanisms of miR172a and its target gene LbrTOE3 regulating maturation in Lilium
Main conclusionLbr -miR172a could promote the growth phase transition and shorten maturation in Lilium , while LbrTOE3 inhibited this process and...
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Maturation and Assembly of mTOR Complexes by the HSP90-R2TP-TTT Chaperone System: Molecular Insights and Mechanisms
The mechanistic target of rapamycin (mTOR) is a master regulator of cell growth and metabolism, integrating environmental signals to regulate...
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A transcriptional enhancer regulates cardiac maturation
Cardiomyocyte maturation is crucial for generating adult cardiomyocytes and the application of human pluripotent stem cell-derived cardiomyocytes...
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Combined small-molecule treatment accelerates maturation of human pluripotent stem cell-derived neurons
The maturation of human pluripotent stem cell (hPSC)-derived neurons mimics the protracted timing of human brain development, extending over months...
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Microbes control Drosophila germline stem cell increase and egg maturation through hormonal pathways
Reproduction is highly dependent on environmental and physiological factors including nutrition, mating stimuli and microbes. Among these factors,...
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LUZP1 regulates the maturation of contractile actomyosin bundles
Contractile actomyosin bundles play crucial roles in various physiological processes, including cell migration, morphogenesis, and muscle...
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Dissecting the molecular mechanisms of mitochondrial import and maturation of peroxiredoxins from yeast and mammalian cells
Peroxiredoxins (Prxs) are cysteine-based peroxidases that play a central role in kee** the H 2 O 2 at physiological levels. Eukaryotic cells express...
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ISL1 controls pancreatic alpha cell fate and beta cell maturation
BackgroundGlucose homeostasis is dependent on functional pancreatic α and ß cells. The mechanisms underlying the generation and maturation of these...
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Quantitative Spatio-temporal Analysis of Phagosome Maturation in Live Cells
Phagocytosis and phagosome maturation are central processes to the development of the innate and adaptive immune response. Phagosome maturation is a...
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AMPK activator-treated human cardiac spheres enhance maturation and enable pathological modeling
BackgroundCardiac pathological outcome of metabolic remodeling is difficult to model using cardiomyocytes derived from human-induced pluripotent stem...
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Adaptable, turn-on maturation (ATOM) fluorescent biosensors for multiplexed detection in cells
A grand challenge in biosensor design is to develop a single-molecule, fluorescent protein-based platform that can be easily adapted to recognize...
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Nuclear receptor RXRα binds the precursor of miR-103 to inhibit its maturation
BackgroundThe maturation of microRNAs (miRNAs) successively undergoes Drosha, Dicer, and Argonaute ˗mediated processing, however, the intricate...
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Generation of Fetal Intestinal Organoids and Their Maturation into Adult Intestinal Cells
During embryonic development, the gut tube undergoes massive morphological changes from the simple tube structure composed of the pseudostratified...
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Omentin-1 drives cardiomyocyte cell cycle arrest and metabolic maturation by interacting with BMP7
Mammalian cardiomyocytes (CMs) undergo maturation during postnatal heart development to meet the increased demands of growth. Here, we found that...
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Transcriptome analysis of Schizothorax oconnori (Cypriniformes: Cyprinidae) oocytes: The role of K+ in promoting yolk globule fusion and regulating oocyte maturation
Schizothorax oconnori ( S. oconnori ) is an economically important fish in Tibet. Oocyte maturation is a physiological process that is of great...
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Maturation-dependent changes in the size, structure and seeding capacity of Aβ42 amyloid fibrils
Many proteins self-assemble to form amyloid fibrils, which are highly organized structures stabilized by a characteristic cross-β network of hydrogen...
