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Protein Interaction Screen on a Peptide Matrix (PrISMa)
Protein-protein interactions (PPI) are essential to understanding the cellular function and key mechanisms necessary for life. Although understanding...
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BDM: An Assessment Metric for Protein Complex Structure Models Based on Distance Difference Matrix
AbstractProtein complex structure prediction is an important problem in computational biology. While significant progress has been made for protein...
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Intracellular cartilage oligomeric matrix protein augments breast cancer resistance to chemotherapy
Chemotherapy persists as the primary intervention for breast cancer, with chemoresistance posing the principal obstacle to successful treatment....
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Glial fibrillary acidic protein, neurofilament light, matrix metalloprotease 3 and fatty acid binding protein 4 as non-invasive brain tumor biomarkers
BackgroundGliomas are aggressive malignant tumors, with poor prognosis. There is an unmet need for the discovery of new, non-invasive biomarkers for...
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Inter-organellar and systemic responses to impaired mitochondrial matrix protein import in skeletal muscle
Effective protein import from cytosol is critical for mitochondrial functions and metabolic regulation. We describe here the mammalian...
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HcN57, A Novel Unusual Acidic Silk-Like Matrix Protein from Hyriopsis cumingii, Participates in Framework Construction and Nacre Nucleation During Nacreous Layer Formation
In the classic molecular model of nacreous layer formation, unusual acidic matrix proteins rich in aspartic acid (Asp) residues are essential for...
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Matrix Gla Protein drives stemness and tumor initiation in ovarian cancer
Ovarian cancer (OC) displays the highest mortality among gynecological tumors, mainly due to early peritoneal dissemination, the high frequency of...
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Surface-layer protein is a public-good matrix exopolymer for microbial community organisation in environmental anammox biofilms
Extracellular polymeric substances (EPS) are core biofilm components, yet how they mediate interactions within and contribute to the structuring of...
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Loss of the centrosomal protein ALMS1 alters lipid metabolism and the regulation of extracellular matrix-related processes
BackgroundAlström syndrome (ALMS) is a rare autosomal recessive disease that is associated with mutations in ALMS1 gene. The main clinical...
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Matrix protein Tenascin-C promotes kidney fibrosis via STAT3 activation in response to tubular injury
Accumulating evidence indicates that the extracellular matrix (ECM) is not only a consequence of fibrosis, but also contributes to the progression of...
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Protein-Protein Binding Kinetics by Biolayer Interferometry
The specific kinetics and thermodynamics of protein-protein interactions underlie the molecular mechanisms of cellular functions; hence the...
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Protein features fusion using attributed network embedding for predicting protein-protein interaction
BackgroundProtein-protein interactions (PPIs) hold significant importance in biology, with precise PPI prediction as a pivotal factor in...
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Shell Matrix Protein N38 of Pinctada fucata, Inducing Vaterite Formation, Extends the DING Protein to the Mollusca World
In the animal kingdom, DING proteins were only found in Chordata and Aschelminthes . At present study, a potential DING protein, matrix protein N38,...
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Cell specialization in cyanobacterial biofilm development revealed by expression of a cell-surface and extracellular matrix protein
Cyanobacterial biofilms are ubiquitous and play important roles in diverse environments, yet, understanding of the processes underlying the...
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Influenza viral matrix 1 protein aggravates viral pathogenicity by inducing TLR4-mediated reactive oxygen species production and apoptotic cell death
Influenza virus is one of the most challenging viruses threating human health. Since infection with influenza virus triggers inflammatory responses...
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Correlation between small-cell lung cancer serum protein/peptides determined by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and chemotherapy efficacy
BackgroundCurrently, no effective measures are available to predict the curative efficacy of small-cell lung cancer (SCLC) chemotherapy. We expect to...
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Probing the interactions of the HIV-1 matrix protein-derived polybasic region with lipid bilayers: insights from AFM imaging and force spectroscopy
The human immunodeficiency virus type 1 (HIV-1) matrix protein contains a highly basic region, MA-HBR, crucial for various stages of viral...
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Predicting disease severity in metachromatic leukodystrophy using protein activity and a patient phenotype matrix
BackgroundMetachromatic leukodystrophy (MLD) is a lysosomal storage disorder caused by mutations in the arylsulfatase A gene ( ARSA ) and categorized...
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Local and Systemic Regulation of Mineralization: Role of Coupling Factors, Pyrophosphate, Polyphosphates, Vitamin D, Fetuin, Matrix Gla Protein, and Osteopontin
The chapter addresses mechanisms by which inhibitory factors regulate hard tissue deposition and explains how bone cells collectively control new...
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Ursonic acid inhibits migration and invasion of human osteosarcoma cells through the suppression of mitogen-activated protein kinases and matrix metalloproteinases
IntroductionOsteosarcoma (OS) is the most common form of bone malignancy. Although contemporary chemotherapy and surgery have improved the prognosis...
