Search
Search Results
-
MSC-Derived Exosomes: Advances in Cell-Free Therapy
Mesenchymal stem cells (MSCs)Mesenchymal stem cells (MSCs) are a rich source of bioactive molecules, which they secrete as a part of their paracrine...
-
MSC-Based Cell Therapy for COVID-19-Associated ARDS and Classical ARDS: Comparative Perspectives
Purpose of ReviewDespite no general conclusions regarding the therapeutic effect of MSCs on virus-induced acute lung injury in pre-clinical studies,...
-
MSC-Derived Exosomes: Advances in Cell-Free Therapy
Mesenchymal stem cells (MSCs)Mesenchymal stem cells (MSCs) are a rich source of bioactive molecules, which they secrete as a part of their paracrine...
-
Possibilities and efficiency of MSC co-transfection for gene therapy
Mesenchymal stem/stromal cells (MSCs) are not only capable of self-renewal, trans-differentiation, homing to damaged tissue sites and...
-
hUC-MSC transplantation therapy effects on lupus-prone MRL/lpr mice at early disease stages
BackgroundThe efficacy of human umbilical cord mesenchymal stem cell (hUC-MSC) transplantation in treating systemic lupus erythematosus (SLE) has...
-
Mesenchymal stromal/stem cell (MSC)-derived exosomes in clinical trials
Mesenchymal stromal/stem cells (MSCs) are widely utilized in cell therapy because of their robust immunomodulatory and regenerative properties. Their...
-
First Clinical Experiences Using Preconditioning Approaches to Improve MSC-Based Therapies
Purpose of ReviewDescribe the rationale for preconditioning MSCs prior to use as therapy and the state-of-the-art of using preconditioning of MSCs in...
-
The safety of MSC therapy over the past 15 years: a meta-analysis
BackgroundDespite increasing clinical investigations emphasizing the safety of mesenchymal stem cell (MSC) therapy in different populations with...
-
Osteogenic human MSC-derived extracellular vesicles regulate MSC activity and osteogenic differentiation and promote bone regeneration in a rat calvarial defect model
BackgroundThere is growing evidence that extracellular vesicles (EVs) play a crucial role in the paracrine mechanisms of transplanted human...
-
Meta-analysis on last ten years of clinical injection of bone marrow-derived and umbilical cord MSC to reverse cirrhosis or rescue patients with acute-on-chronic liver failure
BackgroundRecent studies have shown that mesenchymal stem cell (MSC) therapy has potential therapeutic effects for patients with end-stage liver...
-
Vocal fold restoration after scarring: biocompatibility and efficacy of an MSC-based bioequivalent
BackgroundThere is growing interest to application of regenerative medicine approaches in otorhinolaryngological practice, especially in the...
-
Efferocytosis of viable versus heat-inactivated MSC induces human monocytes to distinct immunosuppressive phenotypes
BackgroundImmunomodulation by mesenchymal stromal cells (MSCs) can occur through trophic factor mechanisms, however, intravenously infused MSCs are...
-
Investigating the potential of oncolytic viruses for cancer treatment via MSC delivery
Mesenchymal stem cells (MSCs) have attracted considerable interest as a promising approach for cancer treatment due to their ability to undergo...
-
MSC-derived exosomes protect auditory hair cells from neomycin-induced damage via autophagy regulation
BackgroundSensorineural hearing loss (SNHL) poses a major threat to both physical and mental health; however, there is still a lack of effective...
-
IGF2BP3-mediated enhanced stability of MYLK represses MSC adipogenesis and alleviates obesity and insulin resistance in HFD mice
Mesenchymal stem cells (MSCs) hold immense potential as multipotent stem cells and serve as a primary source of adipocytes. The process of MSC...
-
Bioengineered MSCCxcr2 transdifferentiated keratinocyte-like cell-derived organoid potentiates skin regeneration through ERK1/2 and STAT3 signaling in diabetic wound
Skin regeneration is severely compromised in diabetic foot ulcers. Allogeneic mesenchymal stem cell (MSC) transplantation is limited due to the poor...
-
MSC and HSPC Coculture: Mimicking Ex Vivo Bone Marrow Niche
Mesenchymal stromal cells (MSCs) are the crucial component of the hematopoietic stem and progenitor cell (HSPC) niche in the bone marrow. Therefore,...
-
Latest Advances in Mesenchymal Stem Cell-Based Therapy of Eye Diseases
Mesenchymal stem cells (MSCs) possess potent immunomodulatory and regenerative properties. They are, therefore, considered potential new therapeutic...
-
MSC-derived mitochondria promote axonal regeneration via Atf3 gene up-regulation by ROS induced DNA double strand breaks at transcription initiation region
BackgroundThe repair of peripheral nerve injury poses a clinical challenge, necessitating further investigation into novel therapeutic approaches. In...
-
Therapeutic utility of mesenchymal stromal cell (MSC)-based approaches in chronic neurodegeneration: a glimpse into underlying mechanisms, current status, and prospects
Recently, mesenchymal stromal cell (MSC)-based therapy has become an appreciated therapeutic approach in the context of neurodegenerative disease...
