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Lung development and regeneration: newly defined cell types and progenitor status
The lung is the most critical organ of the respiratory system supporting gas exchange. Constant interaction with the external environment makes the...
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Lung Organoids: A New Pathway into Lung Regeneration and Repair
Introduction: The lung is an important and complicated organ that has profound impacts on the entire body when impacted by disease or illness. Due to...
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Simple Models of Lung Development
Models are essential to further our understanding of lung development and regeneration and to facilitate identification and testing of potential...
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Epithelial Stem Cell Regeneration in Acute and Chronic Airway Injury
Airway epithelial stem cells are critical to maintaining airway homeostasis, especially after injury and illness. The loss of intact epithelium in...
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Wnt signaling in lung development, regeneration, and disease progression
The respiratory tract is a vital, intricate system for several important biological processes including mucociliary clearance, airway conductance,...
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Influence of intersignaling crosstalk on the intracellular localization of YAP/TAZ in lung cells
A cell is a dynamic system in which various processes occur simultaneously. In particular, intra- and intercellular signaling pathway crosstalk has a...
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Engineering and Modeling the Lung Mesenchyme
The structure of the mammalian lung controls the flow of air through the airways and into the distal alveolar region where gas exchange occurs....
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Autophagy-modulating biomaterials: multifunctional weapons to promote tissue regeneration
Autophagy is a self-renewal mechanism that maintains homeostasis and can promote tissue regeneration by regulating inflammation, reducing oxidative...
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Sox9-expressing cells promote regeneration after radiation-induced lung injury via the PI3K/AKT pathway
BackgroundRadiation-induced lung injury (RILI) is considered one of the most common complications of thoracic radiation. Recent studies have focused...
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Organoid: a powerful tool to study lung regeneration and disease
Organoids are three-dimensional self-organizing structures formed by adult tissue stem cells or pluripotent stem cells. They recapitulate cell-cell,...
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Tissue Regeneration Processing and Mimicking
Tissue regenerationTissue regeneration has been one of the comprehensive topics that underlie tissue engineeringTissue engineering and has been...
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The diversity of adult lung epithelial stem cells and their niche in homeostasis and regeneration
The adult lung, a workhorse for gas exchange, is continually subjected to a barrage of assaults from the inhaled particles and pathogens. Hence,...
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Lung Organoids: Systematic Review of Recent Advancements and its Future Perspectives
Organoids are essentially an in vitro (lab-grown) three-dimensional tissue culture system model that meticulously replicates the structure and...
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TBX3 is dynamically expressed in pancreatic organogenesis and fine-tunes regeneration
BackgroundThe reactivation of genetic programs from early development is a common mechanism for injury-induced organ regeneration. T-box 3 (TBX3) is...
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Immunomodulation for Tissue Repair and Regeneration
Various immune cells participate in repair and regeneration following tissue injury or damage, orchestrating tissue inflammation and regeneration...
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Epithelial Stem Cell Regeneration in Acute and Chronic Airway Injury
Airway epithelial stem cells are critical to maintaining airway homeostasis, especially after injury and illness. The loss of intact epithelium in...
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Macrophages in tissue repair and regeneration: insights from zebrafish
Macrophages play crucial and versatile roles in regulating tissue repair and regeneration upon injury. However, due to their complex compositional...
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Cell proliferation and regeneration in the gill
Seminal studies from the early 20th century defined the structural changes associated with development and regeneration of the gills in goldfish at...
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Lung-on-a-Chip Models of the Lung Parenchyma
Since the publication of the first lung-on-a-chip in 2010, research has made tremendous progress in mimicking the cellular environment of healthy and...
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Mechanics of Lung Development
We summarize how skeletal muscle and lung developmental biology fields have been bridged to benefit from mouse genetic engineering technologies and...