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Interaction with B-type lamin reveals the function of Drosophila Keap1 xenobiotic response factor in nuclear architecture
BackgroundThe Keap1-Nrf2 pathway serves as a central regulator that mediates transcriptional responses to xenobiotic and oxidative stimuli. Recent...
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Dysfunction of Lamin B and Physiological Aging Cause Telomere Instability in Drosophila Germline
AbstractChromatin spatial organization in the nucleus is essential for the genome functioning and regulation of gene activity. The nuclear lamina and...
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The wide and growing range of lamin B-related diseases: from laminopathies to cancer
B-type lamins are fundamental components of the nuclear lamina, a complex structure that acts as a scaffold for organization and function of the...
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Lamin A upregulation reorganizes the genome during rod photoreceptor degeneration
Neurodegenerative diseases are accompanied by dynamic changes in gene expression, including the upregulation of hallmark stress-responsive genes....
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Unusual Biomolecular Condensates Containing Nucleoporins or Lamin in the Germinal Vesicle of the Common Frog
AbstractThe nucleus (germinal vesicle, GV) of late vitellogenic oocytes of the European common frog, Rana temporaria , was found to contain...
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Lamin B1 curtails early human papillomavirus infection by safeguarding nuclear compartmentalization and autophagic capacity
Human papillomavirus (HPV) infection is a primary cause of cervical and head-and-neck cancers. The HPV genome enters the nucleus during mitosis when...
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Age-dependent Lamin changes induce cardiac dysfunction via dysregulation of cardiac transcriptional programs
As we age, structural changes contribute to progressive decline in organ function, which in the heart act through poorly characterized mechanisms....
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Global crotonylome reveals hypoxia-mediated lamin A crotonylation regulated by HDAC6 in liver cancer
Lysine crotonylation is a recently discovered post-translation modification involved in transcription regulation, cell signal transduction, and other...
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Glycan analysis of Lamin A/C protein at G2/M and S phases of the cell cycle
During mitosis, phosphorylation and dephosphorylation of lamins triggers the nuclear envelope disassembly/assembly. However, it hasn’t been known...
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Lamin A and the LINC complex act as potential tumor suppressors in Ewing Sarcoma
Lamin A, a main constituent of the nuclear lamina, is involved in mechanosignaling and cell migration through dynamic interactions with the LINC...
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Lamin C is required to establish genome organization after mitosis
BackgroundThe dynamic 3D organization of the genome is central to gene regulation and development. The nuclear lamina influences genome organization...
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Eliminating elevated p53 signaling fails to rescue skeletal muscle defects or extend survival in lamin A/C-deficient mice
Lamins A and C, encoded by the LMNA gene, are nuclear intermediate filaments that provide structural support to the nucleus and contribute to...
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Small heat-shock protein HSPB3 promotes myogenesis by regulating the lamin B receptor
One of the critical events that regulates muscle cell differentiation is the replacement of the lamin B receptor (LBR)-tether with the lamin A/C...
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Crystal structure of progeria mutant S143F lamin A/C reveals increased hydrophobicity driving nuclear deformation
Lamins are intermediate filaments that form a 3-D meshwork in the periphery of the nuclear envelope. The recent crystal structure of a long fragment...
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Modeling the 3D Genome Using Hi-C and Nuclear Lamin-Genome Contacts
The three-dimensional (3D) organization of the genome is shaped by interactions with multiple structures within the nucleus, affecting gene...
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Lamin-A interacting protein Hsp90 is required for DNA damage repair and chemoresistance of ovarian cancer cells
Ovarian cancer is the most malignant gynecologic cancer. Previous studies found that lamin-A was associated with DNA damage repair proteins but the...
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Depletion of lamins B1 and B2 promotes chromatin mobility and induces differential gene expression by a mesoscale-motion-dependent mechanism
BackgroundB-type lamins are critical nuclear envelope proteins that interact with the three-dimensional genomic architecture. However, identifying...
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Nuclear peripheral chromatin-lamin B1 interaction is required for global integrity of chromatin architecture and dynamics in human cells
The eukaryotic genome is folded into higher-order conformation accompanied with constrained dynamics for coordinated genome functions. However, the...
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Lamin A as a Determinant of Mechanical Properties of the Cell Nucleus in Health and Disease
AbstractOne of the main factors associated with worse prognosis in oncology is metastasis, which is based on the ability of tumor cells to migrate...