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Ischemia–Reperfusion Injury: Molecular Mechanisms of Pathogenesis and Methods of Their Correction
Abstract —Ischemia–reperfusion is a cascade of complex and interrelated pathological processes underlying many human diseases, including such socially...
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Ferroptosis in organ ischemia–reperfusion injuries: recent advancements and strategies
Ferroptosis is a newly discovered type of regulated cell death participated in multiple diseases. Different from other classical cell death programs...
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MicroRNA-specific therapeutic targets and biomarkers of apoptosis following myocardial ischemia–reperfusion injury
MicroRNAs are single-stranded non-coding RNAs that participate in post-transcriptional regulation of gene expression, it is involved in the...
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Protective Effects of Boric Acid Taken in Different Ways on Experimental Ovarian İschemia and Reperfusion
Ovarian ischemia is a gynecological emergency that occurs as a result of ovarian torsion, affects women of reproductive age, and reduces ovarian...
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Autosis: a new form of cell death in myocardial ischemia–reperfusion injury
Cardiomyocytes undergo a variety of cell death events during myocardial ischemia‒reperfusion injury (MIRI). Understanding the causes of cardiomyocyte...
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Autophagy in hepatic ischemia–reperfusion injury
Hepatic ischemia–reperfusion injury (HIRI) is a major complication of liver resection or liver transplantation that can seriously affect patient’s...
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Cellular and molecular mechanisms of cell damage and cell death in ischemia–reperfusion injury in organ transplantation
Ischemia–reperfusion injury (IRI) is a critical pathological condition in which cell death plays a major contributory role, and negatively impacts...
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Effect of Intranasal Insulin on Metabolic Parameters and Inflammation Factors in Diabetic Rats Exposed to Cerebral Ischemia-Reperfusion
AbstractThe search for natural biologically active substances having a neuroprotective effect against cerebral ischemia-reperfusion injury is one of...
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Targeting cell death pathways in intestinal ischemia-reperfusion injury: a comprehensive review
Intestinal ischemia-reperfusion (I/R) is a multifaceted pathological process, and there is a lack of clear treatment for intestinal I/R injury....
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Keap1/Nrf2/ARE System Inducers Do Not Increase the Resistance of the Heart to Prolonged Ischemia/Reperfusion
AbstractOxidative stress acts as an important mechanism of myocardial damage during ischemia/reperfusion. To consider the possibility of restoring...
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Integrated bioinformatics analysis of retinal ischemia/reperfusion injury in rats with potential key genes
The tissue damage caused by transient ischemic injury is an essential component of the pathogenesis of retinal ischemia, which mainly hinges on the...
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AMPK, a key molecule regulating aging-related myocardial ischemia-reperfusion injury
Aging leads to the threat of more diseases to the biological anatomical structure and the decline of disease resistance, increasing the incidence and...
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Nrf2 attenuates oxidative stress to mediate the protective effect of ciprofol against cerebral ischemia–reperfusion injury
Neuroinflammation and oxidative stress damage are involved in the pathogenesis of cerebral ischemia–reperfusion injury (CIRI). Ferroptosis emerged as...
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Endothelial cell-derived RSPO3 activates Gαi1/3-Erk signaling and protects neurons from ischemia/reperfusion injury
The current study explores the potential function and the underlying mechanisms of endothelial cell-derived R-spondin 3 (RSPO3) neuroprotection...
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PCSK9 regulates myocardial ischemia–reperfusion injury through parkin/pink1-mediated autophagy pathway
ObjectivesThis study aimed at investigating the role of the proprotein convertase subtilisin/Kexin type 9 (PCSK9)-mediated autophagy on myocardial...
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The forkhead box O3 (FOXO3): a key player in the regulation of ischemia and reperfusion injury
Forkhead box O3 is a protein encoded by the FOXO3 gene expressed throughout the body. FOXO3 could play a crucial role in longevity and many other...
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Myocardial Electrophysiological Response to Ischemia and Reperfusion Depends on the Age of Rats
AbstractAge is a major driver of the risk of acute myocardial infarction and malignant ventricular arrhythmias. However, age-related changes in the...
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GSDMD promotes neutrophil extracellular traps via mtDNA-cGAS-STING pathway during lung ischemia/reperfusion
Lung ischemia/reperfusion injury (LIRI) is a complex pathophysiological process, with the histopathological hallmark of neutrophils migrating into...
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Cellular senescence in ischemia/reperfusion injury
Ischemia/reperfusion (IR) injury, a main reason of mortality and morbidity worldwide, occurs in many organs and tissues. As a result of IR injury,...
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SIRT1 restores mitochondrial structure and function in rats by activating SIRT3 after cerebral ischemia/reperfusion injury
Mitochondrial dysfunction contributes to cerebral ischemia–reperfusion (CI/R) injury, which can be ameliorated by Sirtuin-3 (SIRT3). Under stress...
