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Monitoring of Inflammasome Activation of Macrophages and Microglia In Vitro, Part 1: Cell Preparation and Inflammasome Stimulation
Inflammasomes are intracellular, multiprotein supercomplexes that mediate a post-translational inflammatory response to both pathogen and endogenous...
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Inducing Pyroptosis Via the Pyrin Inflammasome
The pyrin inflammasome detects bacterial toxins and effectors that inhibit RhoA GTPases and triggers inflammatory cytokine release and a fast cell...
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Monitoring of Inflammasome Activation of Macrophages and Microglia In Vitro, Part 2: Assessing Inflammasome Activation
InflammasomesInflammasomes are macromolecular complexes that assemble upon the detection of cytoplasmic pathogen-associated or danger-associated...
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Identifying Inflammasome Activation in Human Tissues
The NACHT, LRR, and PYD domain-containing protein-3 (NLRP3) inflammasome activation is part of a stereotyped cellular response to injury or...
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CARD8 Inflammasome Activation by HIV-1 Protease
The pattern recognition receptor CARD8 is an inflammasome sensor for intracellular HIV-1 protease activity. Previously, the only method for studying...
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Assessment of NLRP3 Inflammasome Activation and NLRP3-NEK7 Complex Assembly
The NLRP3 inflammasome is a critical component of innate immunity that activates caspase-1 to induce inflammation in response to a wide spectrum of...
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Cardiac Inflammasome and Arrhythmia
Cardiac arrhythmias affect the quality of life and are often life threatening. The conventional anti-arrhythmic drugs targeting cardiac ion channels...
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Squaramides enhance NLRP3 inflammasome activation by lowering intracellular potassium
The NLRP3 inflammasome is a component of the inflammatory response to infection and injury, orchestrating the maturation and release of the...
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Angiogenin-mediated tsRNAs control inflammation and metabolic disorder by regulating NLRP3 inflammasome
The cellular stress response system in immune cells plays a crucial role in regulating the development of inflammatory diseases. In response to...
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Dysregulation of inflammasome activation in glioma
Gliomas are the most common brain tumors characterized by complicated heterogeneity. The genetic, molecular, and histological pathology of gliomas is...
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Iguratimod Alleviates Experimental Sjögren’s Syndrome by Inhibiting NLRP3 Inflammasome Activation
Iguratimod (T-614) is a compound widely used as anti-rheumatic drug. This study investigated the effect and underlying mechanism of T-614 on...
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Role of NLRP3 inflammasome in central nervous system diseases
The central nervous system (CNS) is the most delicate system in human body, with the most complex structure and function. It is vulnerable to trauma,...
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The trigger for pancreatic disease: NLRP3 inflammasome
NLRP3 inflammasome is a multiprotein complex expressed in a variety of cells to stimulate the production of inflammatory factors. Activation of NLRP3...
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Role of NLRP3 Inflammasome in Pathogenesis of Ischemic Stroke
AbstractIschemic stroke (IS) is a prevalent condition worldwide with high mortality and disability risks. The issue of its pathogenetic therapy...
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The NLRP3 inflammasome: contributions to inflammation-related diseases
The NOD-like receptor protein 3 (NLRP3) inflammasome is a protein complex that regulates innate immune responses by activating caspase-1 and the...
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Glibenclamide Prevents Inflammation by Targeting NLRP3 Inflammasome Activation in vitro
AbstractThe NLRP3 inflammasome plays a significant role in the development of neurodegeneration, physiological aging and metabolic...
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MafB regulates NLRP3 inflammasome activation by sustaining p62 expression in macrophages
Activation of the NLRP3 inflammasome is a two-step process: the priming and the activating. The priming step involves the induction of NLRP3 and...
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Structural basis of the human NAIP/NLRC4 inflammasome assembly and pathogen sensing
The NLR family caspase activation and recruitment domain-containing 4 (NLRC4) inflammasome is a critical cytosolic innate immune machine formed upon...
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HECTD3 inhibits NLRP3 inflammasome assembly and activation by blocking NLRP3-NEK7 interaction
The NLRP3 inflammasome plays an important role in protecting the host from infection and aseptic inflammation, and its regulatory mechanism is not...
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Mitochondria and NLRP3 inflammasome in cardiac hypertrophy
Cardiac hypertrophy is the main adaptive response of the heart to chronic loads; however, prolonged or excessive hypertrophy promotes myocardial...
