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Topical administration of the secretome derived from human amniotic epithelial cells ameliorates psoriasis-like skin lesions in mice
BackgroundPsoriasis is a chronic inflammatory skin disease. Tissue stem cells have exhibited a therapeutic effect on psoriatic mice. However, the...
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A Sequential Culturing System for Generating Epithelial-Like Stem Cells from Human Mesenchymal Stem Cells Derived from Adipose Tissue
AbstractSkin burn repair requires efficient regeneration in order to achieve proper healing. We applied a sequential culturing system 2D1w/3D2w...
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Bioengineered skin constructs based on mesenchymal stromal cells and acellular dermal matrix exposed to inflammatory microenvironment releasing growth factors involved in skin repair
BackgroundSkin tissue engineering is a rapidly evolving field of research that effectively combines stem cells and biological scaffolds to replace...
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Cellular Heterogeneity and Plasticity of Skin Epithelial Cells in Wound Healing and Tumorigenesis
AbstractCellular differentiation, the fundamental hallmark of cells, plays a critical role in homeostasis. And stem cells not only regulate the...
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IL-33 priming and antigenic stimulation synergistically promote the transcription of proinflammatory cytokine and chemokine genes in human skin mast cells
BackgroundAntigenic stimulation through cross-linking the IgE receptor and epithelial cell-derived cytokine IL-33 are potent stimuli of mast cell...
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Optimization of methods for intrasplenic administration of human amniotic epithelial cells in order to perform safe and effective cell-based therapy for liver diseases
In animal experimental models the administration of stem cells into the spleen should ensure high effectiveness of their implantation in the liver...
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SOX4 reversibly induces phenotypic changes by suppressing the epithelial marker genes in human keratinocytes
BackgroundSOX4 is a transcription factor belonging to the SOX (Sry-related High Mobility Group [HMG] box) family and plays a pivotal role in various...
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An efficient simplified method for the generation of corneal epithelial cells from human pluripotent stem cells
Corneal epithelial cells derived from human pluripotent stem cells (hPSCs) are an important cell source for preclinical models to test ophthalmic...
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Human Epithelial Protein SLURP-2 as a Prototype of Drugs for Wound Healing
AbstractObjective: Wound healing is a complex process based on the regulation of proliferation and migration of epithelial cells. Chronic wounds are...
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Generation and characterization of hair-bearing skin organoids from human pluripotent stem cells
Human skin uses millions of hairs and glands distributed across the body surface to function as an external barrier, thermoregulator and stimuli...
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Mpox virus infection and drug treatment modelled in human skin organoids
Mpox virus (MPXV) primarily infects human skin to cause lesions. Currently, robust models that recapitulate skin infection by MPXV are lacking. Here...
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Potential Therapeutic Effects of Human Amniotic Epithelial Cells on Gynecological Disorders Leading to Infertility or Abortion
AbstractThe induction of feto-maternal tolerance, fetal non-immunogenicity, and the regulation of mother’s immune system are essential variables in a...
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Culturing and Differentiation of Patient-Derived Ectocervical Epithelial Stem Cells Using Air-Liquid Interphase and Matrigel Scaffold
The ectocervix acts as a multilayered defense barrier, protecting the female reproductive system from external pathogens and supporting fertility and...
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Differentiated Epithelial Cells of the Gut
The intestine is a prime example of self-renewal where stem cells give rise to progenitor cells called transit-amplifying cells which differentiate...
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Polar microalgae extracts protect human HaCaT keratinocytes from damaging stimuli and ameliorate psoriatic skin inflammation in mice
BackgroundPolar microalgae contain unique compounds that enable them to adapt to extreme environments. As the skin barrier is our first line of...
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Epigenetic priming of an epithelial enhancer by p63 and CTCF controls expression of a skin-restricted gene XP33
The transcription factor p63 is a renowned master regulator of gene expression of stratified epithelia. While multiple proteins have been identified...
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Derivation of Human Salivary Epithelial Progenitors from Pluripotent Stem Cells via Activation of RA and Wnt Signaling
Derivation of salivary gland epithelial progenitors (SGEPs) from human pluripotent stem cells (hPSCs) has great potential in developmental biology...
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Orthotopic Transplantation of Mouse Mammary Epithelial Cells
The orthotopic transplantation assay has provided important insights into mammary development, stem cell function, and tumorigenesis. Technically, it...
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Viscoelastic parameterization of human skin cells characterize material behavior at multiple timescales
Countless biophysical studies have sought distinct markers in the cellular mechanical response that could be linked to morphogenesis, homeostasis,...
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Adipose-Derived Mesenchymal Stem Cells and Their Derived Epidermal Progenitor Cells Conditioned Media Ameliorate Skin Aging in Rats
BACKGROUND: Skin alterations are among the most prominent signs of aging, and they arise from both intrinsic and extrinsic factors that interact and...
