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Reconstitution of Human Prospermatogonial Development from Human-Induced Pluripotent Stem Cells
There is a scarcity of information regarding the molecular mechanisms underlying human germ cell development due to limitations in obtaining the...
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The migration pattern of cells during the mesoderm and endoderm differentiation from human pluripotent stem cells
Gastrulation is the first major differentiation process in animal embryos. However, the dynamics of human gastrulation remain mostly unknown owing to...
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Establishing extended pluripotent stem cells from human urine cells
BackgroundExtended pluripotent stem cells (EPSCs) can contribute to both embryonic and trophectoderm-derived extraembryonic tissues. Therefore, EPSCs...
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Induction of Human Extraembryonic Mesoderm Cells from Naive Pluripotent Stem Cells
The human extraembryonic mesoderm (EXM) is an important tissue in the postimplantation embryo which is specified before gastrulation in primates but...
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Mesenchymal stem/stromal cells from human pluripotent stem cell-derived brain organoid enhance the ex vivo expansion and maintenance of hematopoietic stem/progenitor cells
BackgroundMesenchymal stem/stromal cells (MSCs) are of great therapeutic value due to their role in maintaining the function of hematopoietic...
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Differentiation of Human Fetal Muscle Stem Cells from Induced Pluripotent Stem Cells
Most muscular dystrophies are the result of genetic disorders. There is currently no effective treatment for these progressive diseases except...
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Generating hematopoietic cells from human pluripotent stem cells: approaches, progress and challenges
Human pluripotent stem cells (hPSCs) have been suggested as a potential source for the production of blood cells for clinical application. In two...
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Generation of Human Blastoids from Naive Pluripotent Stem Cells
Under certain culture conditions, naive human pluripotent stem cells can generate human blastocyst-like structures (called human blastoids). Human...
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Mimicking Islet Development with Human Pluripotent Stem Cells
The development of functional beta cells from human pluripotent stem cells (PSCs) offers a promising approach for treating type 1 diabetes (T1D)....
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Reprogramming of Primed Human Pluripotent Stem Cells into a Naïve State
AbstractHuman pluripotent stem cells (PSCs) can be maintained in a naïve or primed state of pluripotency in vitro. Being in one state or another,...
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Expression Profile of Isogenic Early Mesodermal Cells Differentiated from Human Induced Pluripotent Stem Cells
AbstractScar formation during normal regeneration of damaged tissue can lead to noticeable cosmetic and functional defects of organs and thus...
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Human Naïve Pluripotent Stem Cells
This volume provides readers with a comprehensive collection of methods to guide them on how to generate, characterize, and use naïve human...
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Chondrogenic Differentiation of Human-Induced Pluripotent Stem Cells
The generation of large quantities of genetically defined human chondrocytes remains a critical step for the development of tissue engineering...
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Induced Pluripotent Stem Cells and Human Disease Methods and Protocols
This detailed volume presents a series of protocols that are representative of recent developments and improvements in induced pluripotent stem cells...
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Crispr-Based Editing of Human Pluripotent Stem Cells for Disease Modeling
The CRISPR system, as an effective genome editing technology, has been extensively utilized for the construction of disease models in human...
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Sphere-Based Expansion of Myogenic Progenitors from Human Pluripotent Stem Cells
The protocol presented here is to derive, maintain, and differentiate human pluripotent stem cells into skeletal muscle progenitor/stem cells...
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The origins of human pluripotent stem cells: the road from a cancer to regenerative medicine
The notion of using pluripotent stem cells (PSCs) as a source of differentiated cell types for replacement of disease or damaged tissues in...
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Stepwise differentiation of functional pancreatic β cells from human pluripotent stem cells
Pancreatic β cells differentiated from stem cells provide promise for cell replacement therapy of diabetes. Human pluripotent stem cells could be...
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Human Pluripotent Stem Cell-Based Assays to Predict Developmental Toxicity
Human beings are continuously exposed to various toxic substances throughout their lives, which affect their reproductive health and eventually the...
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Hyaluronan in mesenchymal stromal cell lineage differentiation from human pluripotent stem cells: application in serum free culture
BackgroundHyaluronan (HA) is an extracellular glycosaminoglycan polysaccharide with widespread roles throughout development and in healthy and...
